Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism

por Yeudall, Scott, Upchurch, Clint M., Seegren, Philip V., Pavelec, Caitlin M., Greulich, Jan, Lemke, Michael C., Harris, Thurl E., Desai, Bimal N., Hoehn, Kyle L., Leitinger, Norbert
Publicado 2022

Analogs of FTY720 inhibit TRPM7 but not S1PRs and exert multimodal anti-inflammatory effects

por Busey, Gregory W., Manjegowda, Mohan C., Huang, Tao, Iobst, Wesley H., Naphade, Shardul S., Kennedy, Joel A., Doyle, Catherine A., Seegren, Philip V., Lynch, Kevin R., Desai, Bimal N.
Publicado 2023

Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1

por Cuddy, Sean R, Schinlever, Austin R, Dochnal, Sara, Seegren, Philip V, Suzich, Jon, Kundu, Parijat, Downs, Taylor K, Farah, Mina, Desai, Bimal N, Boutell, Chris, Cliffe, Anna R
Publicado 2020

Efferocytosis requires periphagosomal Ca(2+)-signaling and TRPM7-mediated electrical activity

por Schappe, Michael S., Stremska, Marta E., Busey, Gregory W., Downs, Taylor K., Seegren, Philip V., Mendu, Suresh K., Flegal, Zachary, Doyle, Catherine A., Stipes, Eric J., Desai, Bimal N.
Publicado 2022

Reduced mitochondrial calcium uptake in macrophages is a major driver of inflammaging

por Seegren, Philip V., Harper, Logan R., Downs, Taylor K., Zhao, Xiao-Yu, Viswanathan, Shivapriya B., Stremska, Marta E., Olson, Rachel J., Kennedy, Joel, Ewald, Sarah E., Kumar, Pankaj, Desai, Bimal N.
Publicado 2023

Mitochondrial Ca(2+) Signaling Is an Electrometabolic Switch to Fuel Phagosome Killing

por Seegren, Philip V., Downs, Taylor K., Stremska, Marta E., Harper, Logan R., Cao, Ruofan, Olson, Rachel J., Upchurch, Clint M., Doyle, Catherine A., Kennedy, Joel, Stipes, Eric L., Leitinger, Norbert, Periasamy, Ammasi, Desai, Bimal N.
Publicado 2020