Probing conformational dynamics to understand kinase inhibition

por Outhwaite, Ian R, Seeliger, Markus A
Publicado 2023

Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1

por Kan, Yagmur, Paung, YiTing, Seeliger, Markus A., Miller, W. Todd
Publicado 2023

Kinases on Double Duty: A Review of UniProtKB Annotated Bifunctionality within the Kinome

por Rangwala, Aziz M., Mingione, Victoria R., Georghiou, George, Seeliger, Markus A.
Publicado 2022

Activation of tyrosine kinases by mutation of the gatekeeper threonine

por Azam, Mohammad, Seeliger, Markus A, Gray, Nathanael S, Kuriyan, John, Daley, George Q
Publicado 2008

A dynamically coupled allosteric network underlies binding cooperativity in Src kinase

por Foda, Zachariah H., Shan, Yibing, Kim, Eric T., Shaw, David E., Seeliger, Markus A.
Publicado 2015

Highly Specific, Bi-substrate-Competitive Src Inhibitors from DNA-Templated Macrocycles

por Georghiou, George, Kleiner, Ralph E., Pulkoski-Gross, Michael, Liu, David R., Seeliger, Markus A.
Publicado 2012

Resistance to kinase inhibition through shortened target engagement

por Rangwala, Aziz M., Berger, Benedict-Tilman, Robers, Matthew B., Knapp, Stefan, Seeliger, Markus A.
Publicado 2022

Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

por Tong, Michael, Pelton, Jeff G., Gill, Michelle L., Zhang, Weibing, Picart, Francis, Seeliger, Markus A.
Publicado 2017

A conserved mechanism of DEAD-box ATPase activation by nucleoporins and IP(6) in mRNA export

por Montpetit, Ben, Thomsen, Nathan D., Helmke, Kara J., Seeliger, Markus A., Berger, James M., Weis, Karsten
Publicado 2011

Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme

por Maianti, Juan Pablo, Tan, Grace A., Vetere, Amedeo, Welsh, Amie J., Wagner, Bridget K., Seeliger, Markus A., Liu, David R.
Publicado 2019

Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks

por Weinheimer, Alexandra S., Paung, YiTing, Rageul, Julie, Khan, Arafat, Lo, Natalie, Ho, Brian, Tong, Michael, Alphonse, Sébastien, Seeliger, Markus A., Kim, Hyungjin
Publicado 2022

Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions

por Alford, Vincent M., Kamath, Anushree, Ren, Xiaodong, Kumar, Kunal, Gan, Qianwen, Awwa, Monaf, Tong, Michael, Seeliger, Markus A., Cao, Jian, Ojima, Iwao, Sampson, Nicole S.
Publicado 2017

Structural mechanism of a drug-binding process involving a large conformational change of the protein target

por Ayaz, Pelin, Lyczek, Agatha, Paung, YiTing, Mingione, Victoria R., Iacob, Roxana E., de Waal, Parker W., Engen, John R., Seeliger, Markus A., Shan, Yibing, Shaw, David E.
Publicado 2023

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

por Wang, Likun, Perera, B. Gayani K., Hari, Sanjay B., Bhhatarai, Barun, Backes, Bradley J., Seeliger, Markus A., Schürer, Stephan C., Oakes, Scott A., Papa, Feroz R., Maly, Dustin J.
Publicado 2012

Discovery and molecular basis of subtype-selective cyclophilin inhibitors

por Peterson, Alexander A., Rangwala, Aziz M., Thakur, Manish K., Ward, Patrick S., Hung, Christie, Outhwaite, Ian R., Chan, Alix I., Usanov, Dmitry L., Mootha, Vamsi K., Seeliger, Markus A., Liu, David R.
Publicado 2022

Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance

por Sridaran, Dhivya, Chouhan, Surbhi, Mahajan, Kiran, Renganathan, Arun, Weimholt, Cody, Bhagwat, Shambhavi, Reimers, Melissa, Kim, Eric H., Thakur, Manish K., Saeed, Muhammad A., Pachynski, Russell K., Seeliger, Markus A., Miller, W. Todd, Feng, Felix Y., Mahajan, Nupam P.
Publicado 2022

IFITM proteins assist cellular uptake of diverse linked chemotypes

por Lou, Kevin, Wassarman, Douglas R., Yang, Tangpo, Paung, YiTing, Zhang, Ziyang, O’Loughlin, Thomas A., Moore, Megan K., Egan, Regina K., Greninger, Patricia, Benes, Cyril H., Seeliger, Markus A., Taunton, Jack, Gilbert, Luke A., Shokat, Kevan M.
Publicado 2022

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

por Grey, Michael J., Cloots, Eva, Simpson, Mariska S., LeDuc, Nicole, Serebrenik, Yevgeniy V., De Luca, Heidi, De Sutter, Delphine, Luong, Phi, Thiagarajah, Jay R., Paton, Adrienne W., Paton, James C., Seeliger, Markus A., Eyckerman, Sven, Janssens, Sophie, Lencer, Wayne I.
Publicado 2020