Engineered antibodies: new possibilities for brain PET?

por Sehlin, Dag, Syvänen, Stina
Publicado 2019

Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

por Faresjö, Rebecca, Sehlin, Dag, Syvänen, Stina
Publicado 2023

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease

por Gustavsson, Tobias, Syvänen, Stina, O’Callaghan, Paul, Sehlin, Dag
Publicado 2020

Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer’s Disease

por Meier, Silvio R., Sehlin, Dag, Hultqvist, Greta, Syvänen, Stina
Publicado 2021

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

por Hultqvist, Greta, Syvänen, Stina, Fang, Xiaotian T, Lannfelt, Lars, Sehlin, Dag
Publicado 2017

Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells

por Fang, Xiaotian T., Sehlin, Dag, Lannfelt, Lars, Syvänen, Stina, Hultqvist, Greta
Publicado 2017

Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-β

por Sehlin, Dag, Fang, Xiaotian T., Meier, Silvio R., Jansson, Malin, Syvänen, Stina
Publicado 2017

Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

por Gustafsson, Sofia, Sehlin, Dag, Lampa, Erik, Hammarlund-Udenaes, Margareta, Loryan, Irena
Publicado 2019

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

por Sehlin, Dag, Fang, Xiaotian T., Cato, Linda, Antoni, Gunnar, Lannfelt, Lars, Syvänen, Stina
Publicado 2016

Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer’s Disease

por Zyśk, Marlena, Clausen, Fredrik, Aguilar, Ximena, Sehlin, Dag, Syvänen, Stina, Erlandsson, Anna
Publicado 2019

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

por Faresjö, Rebecca, Bonvicini, Gillian, Fang, Xiaotian T., Aguilar, Ximena, Sehlin, Dag, Syvänen, Stina
Publicado 2021

Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-Aβ-Affibodies

por Faresjö, Rebecca, Lindberg, Hanna, Ståhl, Stefan, Löfblom, John, Syvänen, Stina, Sehlin, Dag
Publicado 2022

Brain pharmacokinetics of mono- and bispecific amyloid-β antibodies in wild-type and Alzheimer’s disease mice measured by high cut-off microdialysis

por Julku, Ulrika, Xiong, Mengfei, Wik, Elin, Roshanbin, Sahar, Sehlin, Dag, Syvänen, Stina
Publicado 2022

Extracellular vesicles from amyloid-β exposed cell cultures induce severe dysfunction in cortical neurons

por Beretta, Chiara, Nikitidou, Elisabeth, Streubel-Gallasch, Linn, Ingelsson, Martin, Sehlin, Dag, Erlandsson, Anna
Publicado 2020

Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

por Söllvander, Sofia, Nikitidou, Elisabeth, Brolin, Robin, Söderberg, Linda, Sehlin, Dag, Lannfelt, Lars, Erlandsson, Anna
Publicado 2016

ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific, brain-penetrating fusion protein

por Bonvicini, Gillian, Syvänen, Stina, Andersson, Ken G., Haaparanta-Solin, Merja, López-Picón, Francisco, Sehlin, Dag
Publicado 2022

Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau

por Banka, Vinay, Kelleher, Andrew, Sehlin, Dag, Hultqvist, Greta, Sigurdsson, Einar M., Syvänen, Stina, Ding, Yu-Shin
Publicado 2023

Perspectives on future Alzheimer therapies: amyloid-β protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer’s disease

por Lannfelt, Lars, Möller, Christer, Basun, Hans, Osswald, Gunilla, Sehlin, Dag, Satlin, Andrew, Logovinsky, Veronika, Gellerfors, Pär
Publicado 2014

Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer’s Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry

por Kaya, Ibrahim, Brinet, Dimitri, Michno, Wojciech, Syvänen, Stina, Sehlin, Dag, Zetterberg, Henrik, Blennow, Kaj, Hanrieder, Jörg
Publicado 2016

The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death

por Söllvander, Sofia, Nikitidou, Elisabeth, Gallasch, Linn, Zyśk, Marlena, Söderberg, Linda, Sehlin, Dag, Lannfelt, Lars, Erlandsson, Anna
Publicado 2018