Cancer patients receiving immune checkpoint inhibitor therapy are at an increased risk for atherosclerotic cardiovascular disease

por Lutgens, Esther, Seijkens, Tom T.P.
Publicado 2020

Statins and immune checkpoint inhibitors: a strategy to improve the efficacy of immunotherapy for cancer?

por Vos, Winnie G, Lutgens, Esther, Seijkens, Tom T P
Publicado 2022

E3 Ubiquitin Ligases as Immunotherapeutic Target in Atherosclerotic Cardiovascular Disease

por Poels, Kikkie, Vos, Winnie G., Lutgens, Esther, Seijkens, Tom T. P.
Publicado 2020

The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease

por Bosmans, Laura A., Bosch, Lena, Kusters, Pascal J.H., Lutgens, Esther, Seijkens, Tom T.P.
Publicado 2020

‘Nur'turing tumor T cell tolerance and exhaustion: novel function for Nuclear Receptor Nur77 in immunity

por Lith, Sanne C., van Os, Bram W., Seijkens, Tom T.P., de Vries, Carlie J.M.
Publicado 2020

Immune checkpoint inhibitor treatment and atherosclerotic cardiovascular disease: an emerging clinical problem

por Poels, Kikkie, Neppelenbroek, Suzanne I.M., Kersten, Marie José, Antoni, M. Louisa, Lutgens, Esther, Seijkens, Tom T.P.
Publicado 2021

The CD40–CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

por Aarts, Suzanne A. B. M., Seijkens, Tom T. P., van Dorst, Koos J. F., Dijkstra, Christine D., Kooij, Gijs, Lutgens, Esther
Publicado 2017

Immuno-PET Imaging of Atherosclerotic Plaques with [(89)Zr]Zr-Anti-CD40 mAb—Proof of Concept

por Poels, Kikkie, Schreurs, Maxime, Jansen, Matthijs, Vugts, Danielle J., Seijkens, Tom T. P., van Dongen, Guus A. M. S., Lutgens, Esther, Beaino, Wissam
Publicado 2022

Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice

por Poels, Kikkie, van Leent, Mandy M. T., Reiche, Myrthe E., Kusters, Pascal J. H., Huveneers, Stephan, de Winther, Menno P. J., Mulder, Willem J. M., Lutgens, Esther, Seijkens, Tom T. P.
Publicado 2020

Inhibition of PFKFB3 Hampers the Progression of Atherosclerosis and Promotes Plaque Stability

por Poels, Kikkie, Schnitzler, Johan G., Waissi, Farahnaz, Levels, Johannes H. M., Stroes, Erik S. G., Daemen, Mat J. A. P., Lutgens, Esther, Pennekamp, Anne-Marije, De Kleijn, Dominique P. V., Seijkens, Tom T. P., Kroon, Jeffrey
Publicado 2020

Ablation of CD8α(+) dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice

por Legein, Bart, Janssen, Edith M., Theelen, Thomas L., Gijbels, Marion J., Walraven, Joep, Klarquist, Jared S., Hennies, Cassandra M., Wouters, Kristiaan, Seijkens, Tom T.P., Wijnands, Erwin, Sluimer, Judith C., Lutgens, Esther, Zenke, Martin, Hildner, Kai, Biessen, Erik A.L., Temmerman, Lieve
Publicado 2015

Author Correction: Ablation of CD8α(+) dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice

por Legein, Bart, Janssen, Edith M., Theelen, Thomas L., Gijbels, Marion J., Walraven, Joep, Klarquist, Jared S., Hennies, Cassandra M., Wouters, Kristiaan, Seijkens, Tom T. P., Wijnands, Erwin, Sluimer, Judith C., Lutgens, Esther, Zenke, Martin, Hildner, Kai, Biessen, Erik A. L., Temmerman, Lieve
Publicado 2020

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

por Aarts, Suzanne A. B. M., Seijkens, Tom T. P., Kusters, Pascal J. H., van der Pol, Susanne M. A., Zarzycka, Barbara, Heijnen, Priscilla D. A. M., Beckers, Linda, den Toom, Myrthe, Gijbels, Marion J. J., Boon, Louis, Weber, Christian, de Vries, Helga E., Nicolaes, Gerry A. F., Dijkstra, Christine D., Kooij, Gijs, Lutgens, Esther
Publicado 2017

Immune Checkpoint Inhibitor Therapy Aggravates T Cell–Driven Plaque Inflammation in Atherosclerosis

por Poels, Kikkie, van Leent, Mandy M.T., Boutros, Celine, Tissot, Hubert, Roy, Séverine, Meerwaldt, Anu E., Toner, Yohana C.A., Reiche, Myrthe E., Kusters, Pascal J.H., Malinova, Tsveta, Huveneers, Stephan, Kaufman, Audrey E., Mani, Venkatesh, Fayad, Zahi A., de Winther, Menno P.J., Marabelle, Aurelien, Mulder, Willem J.M., Robert, Caroline, Seijkens, Tom T.P., Lutgens, Esther
Publicado 2020

Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8(+) T cell-mediated macrophage death

por Seijkens, Tom T P, Poels, Kikkie, Meiler, Svenja, van Tiel, Claudia M, Kusters, Pascal J H, Reiche, Myrthe, Atzler, Dorothee, Winkels, Holger, Tjwa, Marc, Poelman, Hessel, Slütter, Bram, Kuiper, Johan, Gijbels, Marion, Kuivenhoven, Jan Albert, Matic, Ljubica Perisic, Paulsson-Berne, Gabrielle, Hedin, Ulf, Hansson, Göran K, Nicolaes, Gerry A F, Daemen, Mat J A P, Weber, Christian, Gerdes, Norbert, de Winther, Menno P J, Lutgens, Esther
Publicado 2019

Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease

por Lacy, Michael, Bürger, Christina, Shami, Annelie, Ahmadsei, Maiwand, Winkels, Holger, Nitz, Katrin, van Tiel, Claudia M., Seijkens, Tom T. P., Kusters, Pascal J. H., Karshovka, Ela, Prange, Koen H. M., Wu, Yuting, Brouns, Sanne L. N., Unterlugauer, Sigrid, Kuijpers, Marijke J. E., Reiche, Myrthe E., Steffens, Sabine, Edsfeldt, Andreas, Megens, Remco T. A., Heemskerk, Johan W. M., Goncalves, Isabel, Weber, Christian, Gerdes, Norbert, Atzler, Dorothee, Lutgens, Esther
Publicado 2021

Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates

por Lameijer, Marnix, Binderup, Tina, van Leent, Mandy M.T., Senders, Max L., Fay, Francois, Malkus, Joost, Sanchez-Gaytan, Brenda L., Teunissen, Abraham J. P., Karakatsanis, Nicolas, Robson, Philip, Zhou, Xianxiao, Ye, Yuxiang, Wojtkiewicz, Gregory, Tang, Jun, Seijkens, Tom T.P., Kroon, Jeffrey, Stroes, Erik S.G., Kjaer, Andreas, Ochando, Jordi, Reiner, Thomas, Pérez-Medina, Carlos, Calcagno, Claudia, Fischer, Edward A., Zhang, Bin, Temel, Ryan E., Swirski, Filip K., Nahrendorf, Matthias, Fayad, Zahi A., Lutgens, Esther, Mulder, Willem J.M., Duivenvoorden, Raphaël
Publicado 2018

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

por Seijkens, Tom T.P., van Tiel, Claudia M., Kusters, Pascal J.H., Atzler, Dorothee, Soehnlein, Oliver, Zarzycka, Barbara, Aarts, Suzanne A.B.M., Lameijer, Marnix, Gijbels, Marion J., Beckers, Linda, den Toom, Myrthe, Slütter, Bram, Kuiper, Johan, Duchene, Johan, Aslani, Maria, Megens, Remco T.A., van ‘t Veer, Cornelis, Kooij, Gijs, Schrijver, Roy, Hoeksema, Marten A., Boon, Louis, Fay, Francois, Tang, Jun, Baxter, Samantha, Jongejan, Aldo, Moerland, Perry D., Vriend, Gert, Bleijlevens, Boris, Fisher, Edward A., Duivenvoorden, Raphael, Gerdes, Norbert, de Winther, Menno P.J., Nicolaes, Gerry A., Mulder, Willem J.M., Weber, Christian, Lutgens, Esther
Publicado 2018