Targeting the K-Ras - JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation

por Okada, Masashi, Shibuya, Keita, Sato, Atsushi, Seino, Shizuka, Suzuki, Shuhei, Seino, Manabu, Kitanaka, Chifumi
Publicado 2014

Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells

por Shibuya, Keita, Okada, Masashi, Suzuki, Shuhei, Seino, Manabu, Seino, Shizuka, Takeda, Hiroyuki, Kitanaka, Chifumi
Publicado 2014

Therapeutic targeting of pancreatic cancer stem cells by dexamethasone modulation of the MKP-1–JNK axis

por Suzuki, Shuhei, Okada, Masashi, Sanomachi, Tomomi, Togashi, Keita, Seino, Shizuka, Sato, Atsushi, Yamamoto, Masahiro, Kitanaka, Chifumi
Publicado 2021

JNK suppression of chemotherapeutic agents-induced ROS confers chemoresistance on pancreatic cancer stem cells

por Suzuki, Shuhei, Okada, Masashi, Shibuya, Keita, Seino, Manabu, Sato, Atsushi, Takeda, Hiroyuki, Seino, Shizuka, Yoshioka, Takashi, Kitanaka, Chifumi
Publicado 2014

The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo

por Okada, Masashi, Kuramoto, Kenta, Takeda, Hiroyuki, Watarai, Hikaru, Sakaki, Hirotsugu, Seino, Shizuka, Seino, Manabu, Suzuki, Shuhei, Kitanaka, Chifumi
Publicado 2016

Repositioning CEP-1347, a chemical agent originally developed for the treatment of Parkinson’s disease, as an anti-cancer stem cell drug

por Okada, Masashi, Takeda, Hiroyuki, Sakaki, Hirotsugu, Kuramoto, Kenta, Suzuki, Shuhei, Sanomachi, Tomomi, Togashi, Keita, Seino, Shizuka, Kitanaka, Chifumi
Publicado 2017

In vitro and in vivo anti-tumor effects of brexpiprazole, a newly-developed serotonin-dopamine activity modulator with an improved safety profile

por Suzuki, Shuhei, Yamamoto, Masahiro, Togashi, Keita, Sanomachi, Tomomi, Sugai, Asuka, Seino, Shizuka, Yoshioka, Takashi, Kitanaka, Chifumi, Okada, Masashi
Publicado 2019

Brexpiprazole, a Serotonin-Dopamine Activity Modulator, Can Sensitize Glioma Stem Cells to Osimertinib, a Third-Generation EGFR-TKI, via Survivin Reduction

por Suzuki, Shuhei, Yamamoto, Masahiro, Sanomachi, Tomomi, Togashi, Keita, Sugai, Asuka, Seino, Shizuka, Yoshioka, Takashi, Kitanaka, Chifumi, Okada, Masashi
Publicado 2019

Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs

por Sanomachi, Tomomi, Suzuki, Shuhei, Togashi, Keita, Sugai, Asuka, Seino, Shizuka, Okada, Masashi, Yoshioka, Takashi, Kitanaka, Chifumi, Yamamoto, Masahiro
Publicado 2019

Doxazosin, a Classic Alpha 1-Adrenoceptor Antagonist, Overcomes Osimertinib Resistance in Cancer Cells via the Upregulation of Autophagy as Drug Repurposing

por Suzuki, Shuhei, Yamamoto, Masahiro, Sanomachi, Tomomi, Togashi, Keita, Sugai, Asuka, Seino, Shizuka, Okada, Masashi, Yoshioka, Takashi, Kitanaka, Chifumi
Publicado 2020

Dexamethasone Sensitizes Cancer Stem Cells to Gemcitabine and 5-Fluorouracil by Increasing Reactive Oxygen Species Production through NRF2 Reduction

por Suzuki, Shuhei, Yamamoto, Masahiro, Sanomachi, Tomomi, Togashi, Keita, Sugai, Asuka, Seino, Shizuka, Yoshioka, Takashi, Okada, Masashi, Kitanaka, Chifumi
Publicado 2021

Gemcitabine radiosensitization primes irradiated malignant meningioma cells for senolytic elimination by navitoclax

por Yamamoto, Masahiro, Sanomachi, Tomomi, Suzuki, Shuhei, Togashi, Keita, Sugai, Asuka, Seino, Shizuka, Sato, Atsushi, Okada, Masashi, Kitanaka, Chifumi
Publicado 2021

Licochalcone A specifically induces cell death in glioma stem cells via mitochondrial dysfunction

por Kuramoto, Kenta, Suzuki, Shuhei, Sakaki, Hirotsugu, Takeda, Hiroyuki, Sanomachi, Tomomi, Seino, Shizuka, Narita, Yoshitaka, Kayama, Takamasa, Kitanaka, Chifumi, Okada, Masashi
Publicado 2017

Involvement of GLUT1-mediated glucose transport and metabolism in gefitinib resistance of non-small-cell lung cancer cells

por Suzuki, Shuhei, Okada, Masashi, Takeda, Hiroyuki, Kuramoto, Kenta, Sanomachi, Tomomi, Togashi, Keita, Seino, Shizuka, Yamamoto, Masahiro, Yoshioka, Takashi, Kitanaka, Chifumi
Publicado 2018

Enhanced Auditory Brainstem Response and Parental Bonding Style in Children with Gastrointestinal Symptoms

por Seino, Shizuka, Watanabe, Satoshi, Ito, Namiko, Sasaki, Konosuke, Shoji, Kaori, Miura, Shoko, Kozawa, Kanoko, Nakai, Kunihiko, Sato, Hiroshi, Kanazawa, Motoyori, Fukudo, Shin
Publicado 2012

Antitumor activity of gemcitabine against high-grade meningioma in vitro and in vivo

por Takeda, Hiroyuki, Okada, Masashi, Kuramoto, Kenta, Suzuki, Shuhei, Sakaki, Hirotsugu, Sanomachi, Tomomi, Seino, Shizuka, Yoshioka, Takashi, Hirano, Hirofumi, Arita, Kazunori, Kitanaka, Chifumi
Publicado 2017

Targeting JNK for therapeutic depletion of stem-like glioblastoma cells

por Matsuda, Ken-ichiro, Sato, Atsushi, Okada, Masashi, Shibuya, Keita, Seino, Shizuka, Suzuki, Kaori, Watanabe, Eriko, Narita, Yoshitaka, Shibui, Soichiro, Kayama, Takamasa, Kitanaka, Chifumi
Publicado 2012

Roles for hENT1 and dCK in gemcitabine sensitivity and malignancy of meningioma

por Yamamoto, Masahiro, Sanomachi, Tomomi, Suzuki, Shuhei, Uchida, Hiroyuki, Yonezawa, Hajime, Higa, Nayuta, Takajo, Tomoko, Yamada, Yuki, Sugai, Asuka, Togashi, Keita, Seino, Shizuka, Okada, Masashi, Sonoda, Yukihiko, Hirano, Hirofumi, Yoshimoto, Koji, Kitanaka, Chifumi
Publicado 2021