Neuronal overexpression of human TDP-43 in Caenorhabditis elegans causes a range of sensorimotor phenotypes

por Koopman, Mandy, Güngördü, Lale, Seinstra, Renée I., Nollen, Ellen A.A.
Publicado 2023

Neuronal overexpression of hTDP-43 in Caenorhabditis elegans impairs different neuronally controlled behaviors and decreases fecundity

por Koopman, Mandy, Güngördü, Lale, Seinstra, Renée I., Nollen, Ellen A.A.
Publicado 2023

Neuronal overexpression of hTDP-43 in Caenorhabditis elegans impairs motor function

por Koopman, Mandy, Güngördü, Lale, Seinstra, Renée I., Nollen, Ellen A.A.
Publicado 2023

Neuronal overexpression of hTDP-43 in Caenorhabditis elegans mimics the cellular pathology commonly observed in TDP-43 proteinopathies

por Koopman, Mandy, Güngördü, Lale, Seinstra, Renée I., Hogewerf, Wytse, Nollen, Ellen A. A.
Publicado 2023

Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging

por Janssens, Georges E., Lin, Xin-Xuan, Millan-Ariño, Lluís, Kavšek, Alan, Sen, Ilke, Seinstra, Renée I., Stroustrup, Nicholas, Nollen, Ellen A.A., Riedel, Christian G.
Publicado 2019

Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase

por Michels, Helen, Seinstra, Renée I., Uitdehaag, Joost C. M., Koopman, Mandy, van Faassen, Martijn, Martineau, Céline N., Kema, Ido P., Buijsman, Rogier, Nollen, Ellen A. A.
Publicado 2016

The cellular modifier MOAG‐4/SERF drives amyloid formation through charge complementation

por Pras, Anita, Houben, Bert, Aprile, Francesco A, Seinstra, Renée, Gallardo, Rodrigo, Janssen, Leen, Hogewerf, Wytse, Gallrein, Christian, De Vleeschouwer, Matthias, Mata‐Cabana, Alejandro, Koopman, Mandy, Stroo, Esther, de Vries, Minke, Louise Edwards, Samantha, Kirstein, Janine, Vendruscolo, Michele, Falsone, Salvatore Fabio, Rousseau, Frederic, Schymkowitz, Joost, Nollen, Ellen A A
Publicado 2021

Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation

por Sin, Olga, de Jong, Tristan, Mata-Cabana, Alejandro, Kudron, Michelle, Zaini, Mohamad Amr, Aprile, Francesco A., Seinstra, Renée I., Stroo, Esther, Prins, Roméo Willinge, Martineau, Céline N., Wang, Hai Hui, Hogewerf, Wytse, Steinhof, Anne, Wanker, Erich E., Vendruscolo, Michele, Calkhoven, Cornelis F., Reinke, Valerie, Guryev, Victor, Nollen, Ellen A.A.
Publicado 2017

Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing

por Jansen, Iris E., Ye, Hui, Heetveld, Sasja, Lechler, Marie C., Michels, Helen, Seinstra, Renée I., Lubbe, Steven J., Drouet, Valérie, Lesage, Suzanne, Majounie, Elisa, Gibbs, J. Raphael, Nalls, Mike A., Ryten, Mina, Botia, Juan A., Vandrovcova, Jana, Simon-Sanchez, Javier, Castillo-Lizardo, Melissa, Rizzu, Patrizia, Blauwendraat, Cornelis, Chouhan, Amit K., Li, Yarong, Yogi, Puja, Amin, Najaf, van Duijn, Cornelia M., Morris, Huw R., Brice, Alexis, Singleton, Andrew B., David, Della C., Nollen, Ellen A., Jain, Shushant, Shulman, Joshua M., Heutink, Peter
Publicado 2017

Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease

por Perni, Michele, van der Goot, Annemieke, Limbocker, Ryan, van Ham, Tjakko J., Aprile, Francesco A., Xu, Catherine K., Flagmeier, Patrick, Thijssen, Karen, Sormanni, Pietro, Fusco, Giuliana, Chen, Serene W., Challa, Pavan K., Kirkegaard, Julius B., Laine, Romain F., Ma, Kai Yu, Müller, Martin B. D., Sinnige, Tessa, Kumita, Janet R., Cohen, Samuel I. A., Seinstra, Renée, Kaminski Schierle, Gabriele S., Kaminski, Clemens F., Barbut, Denise, De Simone, Alfonso, Knowles, Tuomas P. J., Zasloff, Michael, Nollen, Ellen A. A., Vendruscolo, Michele, Dobson, Christopher M.
Publicado 2021