Leaks in the Pipeline: a Failure Analysis of Gram-Negative Antibiotic Development from 2010 to 2020

por Prasad, Neha K., Seiple, Ian B., Cirz, Ryan T., Rosenberg, Oren S.
Publicado 2022

Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1

por Cotton, Adam D., Nguyen, Duy P., Gramespacher, Josef A., Seiple, Ian B., Wells, James A.
Publicado 2021

Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division

por Zhao, Xiang, Garcia, Jason Q., Tong, Kai, Chen, Xingye, Yang, Bin, Li, Qi, Dai, Zhipeng, Shi, Xiaoyu, Seiple, Ian B., Huang, Bo, Guo, Su
Publicado 2021

Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase

por Díaz, Roberto Efraín, Ecker, Andrew K., Correy, Galen J., Asthana, Pooja, Young, Iris D., Faust, Bryan, Thompson, Michael C., Seiple, Ian B., Van Dyken, Steven J., Locksley, Richard M., Fraser, James S.
Publicado 2023

Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice

por Tolani, Bhairavi, Celli, Anna, Yao, Yanmin, Tan, Yong Zi, Fetter, Richard, Liem, Christina R., de Smith, Adam J., Vasanthakumar, Thamiya, Bisignano, Paola, Cotton, Adam D., Seiple, Ian B., Rubinstein, John L., Jost, Marco, Weissman, Jonathan S.
Publicado 2022

Label-retention expansion microscopy

por Shi, Xiaoyu, Li, Qi, Dai, Zhipeng, Tran, Arthur A., Feng, Siyu, Ramirez, Alejandro D., Lin, Zixi, Wang, Xiaomeng, Chow, Tracy T., Chen, Jiapei, Kumar, Dhivya, McColloch, Andrew R., Reiter, Jeremy F., Huang, Eric J., Seiple, Ian B., Huang, Bo
Publicado 2021

A Platform for the Discovery of New Macrolide Antibiotics

por Seiple, Ian B., Zhang, Ziyang, Jakubec, Pavol, Langlois-Mercier, Audrey, Wright, Peter M., Hog, Daniel T., Yabu, Kazuo, Allu, Senkara Rao, Fukuzaki, Takehiro, Carlsen, Peter N., Kitamura, Yoshiaki, Zhou, Xiang, Condakes, Matthew L., Szczypiński, Filip T., Green, William D., Myers, Andrew G.
Publicado 2016

Synthetic group A streptogramin antibiotics that overcome Vat resistance

por Li, Qi, Pellegrino, Jenna, Lee, D. John, Tran, Arthur A., Chaires, Hector A., Wang, Ruoxi, Park, Jesslyn E., Ji, Kaijie, Chow, David, Zhang, Na, Brilot, Axel F., Biel, Justin T., van Zundert, Gydo, Borrelli, Kenneth, Shinabarger, Dean, Wolfe, Cindy, Murray, Beverly, Jacobson, Matthew P., Mühle, Estelle, Chesneau, Olivier, Fraser, James S., Seiple, Ian B.
Publicado 2020