The impact of mismatch repair status and systemic inflammatory markers on radiological staging in colon cancer

por Platt, James R, Ansett, Jennifer, Seligmann, Jenny F, West, Nicholas P, Tolan, Damian J M
Publicado 2023

The Evolving Biomarker Landscape for Treatment Selection in Metastatic Colorectal Cancer

por Taieb, Julien, Jung, Andreas, Sartore-Bianchi, Andrea, Peeters, Marc, Seligmann, Jenny, Zaanan, Aziz, Burdon, Peter, Montagut, Clara, Laurent-Puig, Pierre
Publicado 2019

Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial

por Morton, Dion, Seymour, Matthew, Magill, Laura, Handley, Kelly, Glasbey, James, Glimelius, Bengt, Palmer, Andy, Seligmann, Jenny, Laurberg, Søren, Murakami, Keigo, West, Nick, Quirke, Philip, Gray, Richard
Publicado 2023

Inhibition of EGFR, HER2, and HER3 signalling in patients with colorectal cancer wild-type for BRAF, PIK3CA, KRAS, and NRAS (FOCUS4-D): a phase 2–3 randomised trial

por Adams, Richard, Brown, Ewan, Brown, Louise, Butler, Rachel, Falk, Stephen, Fisher, David, Kaplan, Richard, Quirke, Phil, Richman, Susan, Samuel, Leslie, Seligmann, Jenny, Seymour, Matt, Shiu, Kai Keen, Wasan, Harpreet, Wilson, Richard, Maughan, Tim
Publicado 2017

Molecular subtype-specific efficacy of anti-EGFR therapy in colorectal cancer is dependent on the chemotherapy backbone

por ten Hoorn, Sanne, Sommeijer, Dirkje W., Elliott, Faye, Fisher, David, de Back, Tim R., Trinh, Anne, Koens, Lianne, Maughan, Tim, Seligmann, Jenny, Seymour, Matthew T., Quirke, Phil, Adams, Richard, Richman, Susan D., Punt, Cornelis J. A., Vermeulen, Louis
Publicado 2021

Experiences of running a stratified medicine adaptive platform trial: Challenges and lessons learned from 10 years of the FOCUS4 trial in metastatic colorectal cancer

por Brown, Louise C, Graham, Janet, Fisher, David, Adams, Richard, Seligmann, Jenny, Seymour, Matthew, Kaplan, Richard, Yates, Emma, Parmar, Mahesh, Richman, Susan D, Quirke, Philip, Butler, Rachel, Shiu, Kaikeen, Middleton, Gary, Samuel, Leslie, Wilson, Richard H, Maughan, Timothy S
Publicado 2022

Capecitabine Versus Active Monitoring in Stable or Responding Metastatic Colorectal Cancer After 16 Weeks of First-Line Therapy: Results of the Randomized FOCUS4-N Trial

por Adams, Richard A., Fisher, David J., Graham, Janet, Seligmann, Jenny F., Seymour, Matthew, Kaplan, Richard, Yates, Emma, Parmar, Mahesh, Richman, Susan D., Quirke, Philip, Butler, Rachel, Brown, Ewan, Collinson, Fiona, Falk, Stephen, Wasan, Harpreet, Shiu, Kai-Keen, Middleton, Gary, Samuel, Leslie, Wilson, Richard H., Brown, Louise C., Maughan, Timothy S.
Publicado 2021

A Phase II trial of Higher RadiOtherapy Dose In The Eradication of early rectal cancer (APHRODITE): protocol for a multicentre, open-label randomised controlled trial

por Hudson, Eleanor M, Noutch, Samantha, Brown, Sarah, Adapala, Ravi, Bach, Simon P, Burnett, Carole, Burrage, Alwyn, Gilbert, Alexandra, Hawkins, Maria, Howard, Debra, Jefford, Monica, Kochhar, Rohit, Saunders, Mark, Seligmann, Jenny, Smith, Alexandra, Teo, Mark, Webb, Edward JD, Webster, Amanda, West, Nicholas, Sebag-Montefiore, David, Gollins, Simon, Appelt, Ane L
Publicado 2022

Inhibition of WEE1 Is Effective in TP53- and RAS-Mutant Metastatic Colorectal Cancer: A Randomized Trial (FOCUS4-C) Comparing Adavosertib (AZD1775) With Active Monitoring

por Seligmann, Jenny F., Fisher, David J., Brown, Louise C., Adams, Richard A., Graham, Janet, Quirke, Philip, Richman, Susan D., Butler, Rachel, Domingo, Enric, Blake, Andrew, Yates, Emma, Braun, Michael, Collinson, Fiona, Jones, Rob, Brown, Ewan, de Winton, Emma, Humphrey, Timothy C., Parmar, Mahesh, Kaplan, Richard, Wilson, Richard H., Seymour, Matthew, Maughan, Timothy S.
Publicado 2021

Associations between AI-Assisted Tumor Amphiregulin and Epiregulin IHC and Outcomes from Anti-EGFR Therapy in the Routine Management of Metastatic Colorectal Cancer

por Williams, Christopher J.M., Elliott, Faye, Sapanara, Nancy, Aghaei, Faranak, Zhang, Liping, Muranyi, Andrea, Yan, Dongyao, Bai, Isaac, Zhao, Zuo, Shires, Michael, Wood, Henry M., Richman, Susan D., Hemmings, Gemma, Hale, Michael, Bottomley, Daniel, Galvin, Leanne, Cartlidge, Caroline, Dance, Sarah, Bacon, Chris M., Mansfield, Laura, Young-Zvandasara, Kathe, Sudan, Ajay, Lambert, Katy, Bibby, Irena, Coupland, Sarah E., Montazeri, Amir, Kipling, Natalie, Hughes, Kathryn, Cross, Simon S., Dewdney, Alice, Pheasey, Leanne, Leng, Cathryn, Gochera, Tatenda, Mangham, D. Chas, Saunders, Mark, Pritchard, Martin, Stott, Helen, Mukherjee, Abhik, Ilyas, Mohammad, Silverman, Rafael, Hyland, Georgina, Sculthorpe, Declan, Thornton, Kirsty, Gould, Imogen, O'Callaghan, Ann, Brown, Nicholas, Turnbull, Samantha, Shaw, Lisa, Seymour, Matthew T., West, Nicholas P., Seligmann, Jenny F., Singh, Shalini, Shanmugam, Kandavel, Quirke, Philip
Publicado 2023