Physiologically‐based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups

por Rüdesheim, Simeon, Selzer, Dominik, Fuhr, Uwe, Schwab, Matthias, Lehr, Thorsten
Publicado 2022

Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling

por Wojtyniak, Jan‐Georg, Britz, Hannah, Selzer, Dominik, Schwab, Matthias, Lehr, Thorsten
Publicado 2020

Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug–Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach

por Fuhr, Laura Maria, Marok, Fatima Zahra, Hanke, Nina, Selzer, Dominik, Lehr, Thorsten
Publicado 2021

Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network

por Marok, Fatima Zahra, Fuhr, Laura Maria, Hanke, Nina, Selzer, Dominik, Lehr, Thorsten
Publicado 2021

In Vitro–In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier

por Kovar, Lukas, Wien, Lena, Selzer, Dominik, Kohl, Yvonne, Bals, Robert, Lehr, Thorsten
Publicado 2022

Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates

por Kovar, Lukas, Schräpel, Christina, Selzer, Dominik, Kohl, Yvonne, Bals, Robert, Schwab, Matthias, Lehr, Thorsten
Publicado 2020

Physiologically Based Pharmacokinetic (PBPK) Modeling of Clopidogrel and Its Four Relevant Metabolites for CYP2B6, CYP2C8, CYP2C19, and CYP3A4 Drug–Drug–Gene Interaction Prediction...

por Loer, Helena Leonie Hanae, Türk, Denise, Gómez-Mantilla, José David, Selzer, Dominik, Lehr, Thorsten
Publicado 2022

A Physiologically Based Pharmacokinetic and Pharmacodynamic Model of the CYP3A4 Substrate Felodipine for Drug–Drug Interaction Modeling

por Fuhr, Laura Maria, Marok, Fatima Zahra, Mees, Maximilian, Mahfoud, Felix, Selzer, Dominik, Lehr, Thorsten
Publicado 2022

Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone

por Rüdesheim, Simeon, Selzer, Dominik, Mürdter, Thomas, Igel, Svitlana, Kerb, Reinhold, Schwab, Matthias, Lehr, Thorsten
Publicado 2022

Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and α-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions

por Rüdesheim, Simeon, Wojtyniak, Jan-Georg, Selzer, Dominik, Hanke, Nina, Mahfoud, Felix, Schwab, Matthias, Lehr, Thorsten
Publicado 2020

A Mechanistic, Enantioselective, Physiologically Based Pharmacokinetic Model of Verapamil and Norverapamil, Built and Evaluated for Drug–Drug Interaction Studies

por Hanke, Nina, Türk, Denise, Selzer, Dominik, Wiebe, Sabrina, Fernandez, Éric, Stopfer, Peter, Nock, Valerie, Lehr, Thorsten
Publicado 2020

Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients

por Kovar, Lukas, Weber, Andreas, Zemlin, Michael, Kohl, Yvonne, Bals, Robert, Meibohm, Bernd, Selzer, Dominik, Lehr, Thorsten
Publicado 2020

External Model Performance Evaluation of Twelve Infliximab Population Pharmacokinetic Models in Patients with Inflammatory Bowel Disease

por Schräpel, Christina, Kovar, Lukas, Selzer, Dominik, Hofmann, Ute, Tran, Florian, Reinisch, Walter, Schwab, Matthias, Lehr, Thorsten
Publicado 2021

Comprehensive Parent–Metabolite PBPK/PD Modeling Insights into Nicotine Replacement Therapy Strategies

por Kovar, Lukas, Selzer, Dominik, Britz, Hannah, Benowitz, Neal, St. Helen, Gideon, Kohl, Yvonne, Bals, Robert, Lehr, Thorsten
Publicado 2020

Pharmacometric Modeling of the Impact of Azelastine Nasal Spray on SARS-CoV-2 Viral Load and Related Symptoms in COVID-19 Patients

por Dings, Christiane, Meiser, Peter, Holzer, Frank, Flegel, Michael, Selzer, Dominik, Nagy, Eszter, Mösges, Ralph, Klussmann, Jens Peter, Lehr, Thorsten
Publicado 2022

Significant impact of time-of-day variation on metformin pharmacokinetics

por Türk, Denise, Scherer, Nina, Selzer, Dominik, Dings, Christiane, Hanke, Nina, Dallmann, Robert, Schwab, Matthias, Timmins, Peter, Nock, Valerie, Lehr, Thorsten
Publicado 2023

A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Drug–Drug–Gene Interaction Model of Metformin and Cimetidine in Healthy Adults and Renally Impaired Individuals

por Hanke, Nina, Türk, Denise, Selzer, Dominik, Ishiguro, Naoki, Ebner, Thomas, Wiebe, Sabrina, Müller, Fabian, Stopfer, Peter, Nock, Valerie, Lehr, Thorsten
Publicado 2020

A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug–Drug Interaction Perpetrators

por Marok, Fatima Zahra, Wojtyniak, Jan-Georg, Fuhr, Laura Maria, Selzer, Dominik, Schwab, Matthias, Weiss, Johanna, Haefeli, Walter Emil, Lehr, Thorsten
Publicado 2023

Influence of Physicochemical Characteristics and Stability of Gold and Silver Nanoparticles on Biological Effects and Translocation across an Intestinal Barrier—A Case Study from I...

por Kohl, Yvonne, Hesler, Michelle, Drexel, Roland, Kovar, Lukas, Dähnhardt-Pfeiffer, Stephan, Selzer, Dominik, Wagner, Sylvia, Lehr, Thorsten, von Briesen, Hagen, Meier, Florian
Publicado 2021

Prediction of Drug–Drug–Gene Interaction Scenarios of (E)-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling

por Kovar, Christina, Kovar, Lukas, Rüdesheim, Simeon, Selzer, Dominik, Ganchev, Boian, Kröner, Patrick, Igel, Svitlana, Kerb, Reinhold, Schaeffeler, Elke, Mürdter, Thomas E., Schwab, Matthias, Lehr, Thorsten
Publicado 2022