Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson’s disease

por Senchuk, Megan M., Van Raamsdonk, Jeremy M., Moore, Darren J.
Publicado 2021

Resistance to Stress Can Be Experimentally Dissociated From Longevity

por Dues, Dylan J, Andrews, Emily K, Senchuk, Megan M, Van Raamsdonk, Jeremy M
Publicado 2019

Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein

por Tyson, Trevor, Senchuk, Megan, Cooper, Jason F., George, Sonia, Van Raamsdonk, Jeremy M., Brundin, Patrik
Publicado 2017

Identification of Novel Therapeutic Targets for Polyglutamine Diseases That Target Mitochondrial Fragmentation

por Traa, Annika, Machiela, Emily, Rudich, Paige D., Soo, Sonja K., Senchuk, Megan M., Van Raamsdonk, Jeremy M.
Publicado 2021

Delaying aging is neuroprotective in Parkinson’s disease: a genetic analysis in C. elegans models

por Cooper, Jason F, Dues, Dylan J, Spielbauer, Katie K, Machiela, Emily, Senchuk, Megan M, Van Raamsdonk, Jeremy M
Publicado 2015

Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson’s disease models

por Cooper, Jason F., Machiela, Emily, Dues, Dylan J., Spielbauer, Katie K., Senchuk, Megan M., Van Raamsdonk, Jeremy M.
Publicado 2017

Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways

por Dues, Dylan J., Andrews, Emily K., Schaar, Claire E., Bergsma, Alexis L., Senchuk, Megan M., Van Raamsdonk, Jeremy M.
Publicado 2016

Targeting Mitochondrial Network Disorganization is Protective in C. elegans Models of Huntington’s Disease

por Machiela, Emily, Rudich, Paige D, Traa, Annika, Anglas, Ulrich, Soo, Sonja K, Senchuk, Megan M, Van Raamsdonk, Jeremy M
Publicado 2021

Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan

por Schaar, Claire E., Dues, Dylan J., Spielbauer, Katie K., Machiela, Emily, Cooper, Jason F., Senchuk, Megan, Hekimi, Siegfried, Van Raamsdonk, Jeremy M.
Publicado 2015

Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans

por Senchuk, Megan M., Dues, Dylan J., Schaar, Claire E., Johnson, Benjamin K., Madaj, Zachary B., Bowman, Megan J., Winn, Mary E., Van Raamsdonk, Jeremy M.
Publicado 2018

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

por Wu, Ziyun, Senchuk, Megan M., Dues, Dylan J., Johnson, Benjamin K., Cooper, Jason F., Lew, Leira, Machiela, Emily, Schaar, Claire E., DeJonge, Heather, Blackwell, T. Keith, Van Raamsdonk, Jeremy M.
Publicado 2018

Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways

por Machiela, Emily, Liontis, Thomas, Dues, Dylan J., Rudich, Paige D., Traa, Annika, Wyman, Leslie, Kaufman, Corah, Cooper, Jason F., Lew, Leira, Nadarajan, Saravanapriah, Senchuk, Megan M., Van Raamsdonk, Jeremy M.
Publicado 2020