Resistant and Resilient mutations in protection against familial Alzheimer’s disease: learning from nature

por Sepulveda-Falla, Diego
Publicado 2023

Cerebral Small Vessel Disease in Sporadic and Familial Alzheimer Disease

por Kalaria, Rajesh N., Sepulveda-Falla, Diego
Publicado 2021

Neural Plasticity during Aging

por Arcos-Burgos, Mauricio, Lopera, Francisco, Sepulveda-Falla, Diego, Mastronardi, Claudio
Publicado 2019

Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia in vitro

por Muth, Christiane, Hartmann, Alexander, Sepulveda-Falla, Diego, Glatzel, Markus, Krasemann, Susanne
Publicado 2019

Protein Predictive Modeling and Simulation of Mutations of Presenilin-1 Familial Alzheimer’s Disease on the Orthosteric Site

por Soto-Ospina, Alejandro, Araque Marín, Pedronel, Bedoya, Gabriel, Sepulveda-Falla, Diego, Villegas Lanau, Andrés
Publicado 2021

Reactive Astrocytes Contribute to Alzheimer’s Disease-Related Neurotoxicity and Synaptotoxicity in a Neuron-Astrocyte Co-culture Assay

por Wasilewski, David, Villalba-Moreno, Nelson David, Stange, Inke, Glatzel, Markus, Sepulveda-Falla, Diego, Krasemann, Susanne
Publicado 2022

Loss of Homeostatic Microglia Signature in Prion Diseases

por Wang, Yue, Hartmann, Kristin, Thies, Edda, Mohammadi, Behnam, Altmeppen, Hermann, Sepulveda-Falla, Diego, Glatzel, Markus, Krasemann, Susanne
Publicado 2022

Decreased Deposition of Beta-Amyloid 1-38 and Increased Deposition of Beta-Amyloid 1-42 in Brain Tissue of Presenilin-1 E280A Familial Alzheimer’s Disease Patients

por Dinkel, Felix, Trujillo-Rodriguez, Diana, Villegas, Andres, Streffer, Johannes, Mercken, Marc, Lopera, Francisco, Glatzel, Markus, Sepulveda-Falla, Diego
Publicado 2020

Cerebrospinal Fluid Mitochondrial DNA in Rapid and Slow Progressive Forms of Alzheimer’s Disease

por Podlesniy, Petar, Llorens, Franc, Puigròs, Margalida, Serra, Nuria, Sepúlveda-Falla, Diego, Schmidt, Christian, Hermann, Peter, Zerr, Inga, Trullas, Ramon
Publicado 2020

Amyloid-β Precursor Protein Modulates the Sorting of Testican-1 and Contributes to Its Accumulation in Brain Tissue and Cerebrospinal Fluid from Patients with Alzheimer Disease

por Barrera-Ocampo, Alvaro, Arlt, Sönke, Matschke, Jakob, Hartmann, Ursula, Puig, Berta, Ferrer, Isidre, Zürbig, Petra, Glatzel, Markus, Sepulveda-Falla, Diego, Jahn, Holger
Publicado 2016

Complement 3(+)-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia

por Hartmann, Kristin, Sepulveda-Falla, Diego, Rose, Indigo V. L., Madore, Charlotte, Muth, Christiane, Matschke, Jakob, Butovsky, Oleg, Liddelow, Shane, Glatzel, Markus, Krasemann, Susanne
Publicado 2019

Susceptibility to cellular stress in PS1 mutant N2a cells is associated with mitochondrial defects and altered calcium homeostasis

por Rojas-Charry, Liliana, Calero-Martinez, Sergio, Morganti, Claudia, Morciano, Giampaolo, Park, Kyungeun, Hagel, Christian, Marciniak, Stefan J., Glatzel, Markus, Pinton, Paolo, Sepulveda-Falla, Diego
Publicado 2020

Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease

por Szaruga, Maria, Veugelen, Sarah, Benurwar, Manasi, Lismont, Sam, Sepulveda-Falla, Diego, Lleo, Alberto, Ryan, Natalie S., Lashley, Tammaryn, Fox, Nick C., Murayama, Shigeo, Gijsen, Harrie, De Strooper, Bart, Chávez-Gutiérrez, Lucía
Publicado 2015

ER stress induced immunopathology involving complement in CADASIL: implications for therapeutics

por Panahi, Mahmod, Hase, Yoshiki, Gallart-Palau, Xavier, Mitra, Sumonto, Watanabe, Atsushi, Low, Roger C, Yamamoto, Yumi, Sepulveda-Falla, Diego, Hainsworth, Atticus H, Ihara, Masafumi, Sze, Siu Kwan, Viitanen, Matti, Behbahani, Homira, Kalaria, Raj N
Publicado 2023

A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer’s disease

por Sepulveda-Falla, Diego, Chavez-Gutierrez, Lucia, Portelius, Erik, Vélez, Jorge I., Dujardin, Simon, Barrera-Ocampo, Alvaro, Dinkel, Felix, Hagel, Christian, Puig, Berta, Mastronardi, Claudio, Lopera, Francisco, Hyman, Bradley T., Blennow, Kaj, Arcos-Burgos, Mauricio, de Strooper, Bart, Glatzel, Markus
Publicado 2020

Evidence of beta amyloid independent small vessel disease in familial Alzheimer's disease

por Littau, Jessica Lisa, Velilla, Lina, Hase, Yoshiki, Villalba‐Moreno, Nelson David, Hagel, Christian, Drexler, Dagmar, Osorio Restrepo, Santiago, Villegas, Andres, Lopera, Francisco, Vargas, Sergio, Glatzel, Markus, Krasemann, Susanne, Quiroz, Yakeel T., Arboleda‐Velasquez, Joseph F., Kalaria, Rajesh, Sepulveda‐Falla, Diego
Publicado 2022

Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease

por Pera, Marta, Alcolea, Daniel, Sánchez-Valle, Raquel, Guardia-Laguarta, Cristina, Colom-Cadena, Martí, Badiola, Nahuai, Suárez-Calvet, Marc, Lladó, Albert, Barrera-Ocampo, Alvaro A., Sepulveda-Falla, Diego, Blesa, Rafael, Molinuevo, José L., Clarimón, Jordi, Ferrer, Isidre, Gelpi, Ellen, Lleó, Alberto
Publicado 2012

Comorbidities in Early-Onset Sporadic versus Presenilin-1 Mutation-Associated Alzheimer’s Disease Dementia: Evidence for Dependency on Alzheimer’s Disease Neuropathological Changes...

por Sepulveda-Falla, Diego, Lanau, Carlos Andrés Villegas, White, Charles, Serrano, Geidy E., Acosta-Uribe, Juliana, Mejía-Cupajita, Barbara, Villalba-Moreno, Nelson David, Lu, Pinzhang, Glatzel, Markus, Kofler, Julia K., Ghetti, Bernardino, Frosch, Matthew P., Restrepo, Francisco Lopera, Kosik, Kenneth S., Beach, Thomas G.
Publicado 2023

Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection

por Henao‐Restrepo, Julián, López‐Murillo, Carolina, Valderrama‐Carmona, Pablo, Orozco‐Santa, Natalia, Gomez, Johana, Gutiérrez‐Vargas, Johanna, Moraga, Renato, Toledo, Jorge, Littau, Jessica Lisa, Härtel, Steffen, Arboleda‐Velásquez, Joseph F., Sepulveda‐Falla, Diego, Lopera, Francisco, Cardona‐Gómez, Gloria Patricia, Villegas, Andrés, Posada‐Duque, Rafael
Publicado 2022

Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators

por O'Hare, Michael, Amarnani, Dhanesh, Whitmore, Hannah A.B., An, Miranda, Marino, Claudia, Ramos, Leslie, Delgado-Tirado, Santiago, Hu, Xinyao, Chmielewska, Natalia, Chandrahas, Anita, Fitzek, Antonia, Heinrich, Fabian, Steurer, Stefan, Ondruschka, Benjamin, Glatzel, Markus, Krasemann, Susanne, Sepulveda-Falla, Diego, Lagares, David, Pedron, Julien, Bushweller, John H., Liu, Paul, Arboleda-Velasquez, Joseph F., Kim, Leo A.
Publicado 2021