Application of quantitative protein mass spectrometric data in the early predictive analysis of target engagement by monoclonal antibodies

por Muliaditan, Morris, Sepp, Armin
Publicado 2022

Cross-species/cross-modality physiologically based pharmacokinetics for biologics: 89Zr-labelled albumin-binding domain antibody GSK3128349 in humans

por Sepp, Armin, Bergström, Mats, Davies, Marie
Publicado 2020

Physiologically-based pharmacokinetic model for pulmonary disposition of protein therapeutics in humans

por Jagdale, Prabhas, Sepp, Armin, Shah, Dhaval K.
Publicado 2022

Modeling bispecific monoclonal antibody interaction with two cell membrane targets indicates the importance of surface diffusion

por Sengers, Bram G., McGinty, Sean, Nouri, Fatma Z., Argungu, Maryam, Hawkins, Emma, Hadji, Aymen, Weber, Andrew, Taylor, Adam, Sepp, Armin
Publicado 2016

Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies

por Coulstock, Edward, Sosabowski, Jane, Ovečka, Milan, Prince, Rob, Goodall, Laura, Mudd, Clare, Sepp, Armin, Davies, Marie, Foster, Julie, Burnet, Jerome, Dunlevy, Gráinne, Walker, Adam
Publicado 2013

Pharmacokinetic Characteristics, Pharmacodynamic Effect and In Vivo Antiviral Efficacy of Liver-Targeted Interferon Alpha

por Rycroft, Daniel, Sosabowski, Jane, Coulstock, Edward, Davies, Marie, Morrey, John, Friel, Sarah, Kelly, Fiona, Hamatake, Robert, Ovečka, Milan, Prince, Rob, Goodall, Laura, Sepp, Armin, Walker, Adam
Publicado 2015

The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans

por Thorneloe, Kevin S., Sepp, Armin, Zhang, Sean, Galinanes-Garcia, Laura, Galette, Paul, Al-Azzam, Wasfi, Vugts, Danielle J., van Dongen, Guus, Elsinga, Phillip, Wiegers, Johan, Glaudemans, Andor W. J. M., Vincent, Veena, Renaux, Jessica, Szapacs, Matt, Birchler, Mary, Cleveland, Matthew, Bergstrom, Mats, Davies, Marie
Publicado 2019

Novel Selection Approaches to Identify Antibodies Targeting Neoepitopes on the C5b6 Intermediate Complex to Inhibit Membrane Attack Complex Formation

por Stach, Lasse, Dinley, Emily K. H., Tournier, Nadia, Bingham, Ryan P., Gormley, Darren A., Bramhall, Jo L., Taylor, Adam, Clarkson, Jane E., Welbeck, Katherine A., Harris, Claire L., Feeney, Maria, Hughes, Jane P., Sepp, Armin, Batuwangala, Thil D., Kitchen, Semra J., Nichols, Eva-Maria
Publicado 2021

In vivo biodistribution and pharmacokinetics of sotrovimab, a SARS-CoV-2 monoclonal antibody, in healthy cynomolgus monkeys

por Aweda, Tolulope A., Cheng, Shih-Hsun, Lenhard, Stephen C., Sepp, Armin, Skedzielewski, Tinamarie, Hsu, Chih-Yang, Marshall, Shelly, Haag, Heather, Kehler, Jonathan, Jagdale, Prabhas, Peter, Alessia, Schmid, Michael A., Gehman, Andrew, Doan, Minh, Mayer, Andrew P., Gorycki, Peter, Fanget, Marie, Colas, Christophe, Smith, Brenda, Maier, Curtis C., Alsaid, Hasan
Publicado 2022