The Diphtheria Toxin Translocation Domain Impairs Receptor Selectivity in Cancer Cell-Targeted Protein Nanoparticles

por Voltà-Durán, Eric, Sánchez, Julieta M., Parladé, Eloi, Serna, Naroa, Vazquez, Esther, Unzueta, Ugutz, Villaverde, Antonio
Publicado 2022

Antibacterial Activity of T22, a Specific Peptidic Ligand of the Tumoral Marker CXCR4

por Serna, Naroa, Carratalá, José Vicente, Conchillo-Solé, Oscar, Martínez-Torró, Carlos, Unzueta, Ugutz, Mangues, Ramón, Ferrer-Miralles, Neus, Daura, Xavier, Vázquez, Esther, Villaverde, Antonio
Publicado 2021

In Vivo Bactericidal Efficacy of GWH1 Antimicrobial Peptide Displayed on Protein Nanoparticles, a Potential Alternative to Antibiotics

por Carratalá, Jose V., Brouillette, Eric, Serna, Naroa, Sánchez-Chardi, Alejandro, Sánchez, Julieta M., Villaverde, Antonio, Arís, Anna, Garcia-Fruitós, Elena, Ferrer-Miralles, Neus, Malouin, François
Publicado 2020

Time-Prolonged Release of Tumor-Targeted Protein–MMAE Nanoconjugates from Implantable Hybrid Materials

por Serna, Naroa, Falgàs, Aïda, García-León, Annabel, Unzueta, Ugutz, Núñez, Yáiza, Sánchez-Chardi, Alejandro, Martínez-Torró, Carlos, Mangues, Ramón, Vazquez, Esther, Casanova, Isolda, Villaverde, Antonio
Publicado 2022

An In Silico Methodology That Facilitates Decision Making in the Engineering of Nanoscale Protein Materials

por Parladé, Eloi, Voltà-Durán, Eric, Cano-Garrido, Olivia, Sánchez, Julieta M., Unzueta, Ugutz, López-Laguna, Hèctor, Serna, Naroa, Cano, Montserrat, Rodríguez-Mariscal, Manuel, Vazquez, Esther, Villaverde, Antonio
Publicado 2022

T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo

por Núñez, Yáiza, Garcia-León, Annabel, Falgàs, Aïda, Serna, Naroa, Sánchez-García, Laura, Garrido, Ana, Sierra, Jorge, Gallardo, Alberto, Unzueta, Ugutz, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon, Casanova, Isolda
Publicado 2023

Artificial Inclusion Bodies for Clinical Development

por Sánchez, Julieta M., López‐Laguna, Hèctor, Álamo, Patricia, Serna, Naroa, Sánchez‐Chardi, Alejandro, Nolan, Verónica, Cano‐Garrido, Olivia, Casanova, Isolda, Unzueta, Ugutz, Vazquez, Esther, Mangues, Ramon, Villaverde, Antonio
Publicado 2019

Selective delivery of T22-PE24-H6 to CXCR4(+) diffuse large B-cell lymphoma cells leads to wide therapeutic index in a disseminated mouse model

por Falgàs, Aïda, Pallarès, Victor, Serna, Naroa, Sánchez-García, Laura, Sierra, Jorge, Gallardo, Alberto, Alba-Castellón, Lorena, Álamo, Patricia, Unzueta, Ugutz, Villaverde, Antonio, Vázquez, Esther, Mangues, Ramon, Casanova, Isolda
Publicado 2020

The Poly-Histidine Tag H6 Mediates Structural and Functional Properties of Disintegrating, Protein-Releasing Inclusion Bodies

por Sánchez, Julieta María, Carratalá, José Vicente, Serna, Naroa, Unzueta, Ugutz, Nolan, Verónica, Sánchez-Chardi, Alejandro, Voltà-Durán, Eric, López-Laguna, Hèctor, Ferrer-Miralles, Neus, Villaverde, Antonio, Vazquez, Esther
Publicado 2022

Self-Assembled Nanobodies as Selectively Targeted, Nanostructured, and Multivalent Materials

por Sánchez-García, Laura, Voltà-Durán, Eric, Parladé, Eloi, Mazzega, Elisa, Sánchez-Chardi, Alejandro, Serna, Naroa, López-Laguna, Hèctor, Mitstorfer, Mara, Unzueta, Ugutz, Vázquez, Esther, Villaverde, Antonio, de Marco, Ario
Publicado 2021

An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination

por Pallarès, Victor, Unzueta, Ugutz, Falgàs, Aïda, Sánchez-García, Laura, Serna, Naroa, Gallardo, Alberto, Morris, Gordon A., Alba-Castellón, Lorena, Álamo, Patricia, Sierra, Jorge, Villaverde, Antonio, Vázquez, Esther, Casanova, Isolda, Mangues, Ramon
Publicado 2020

GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases

por Sala, Rita, Rioja-Blanco, Elisa, Serna, Naroa, Sánchez-García, Laura, Álamo, Patricia, Alba-Castellón, Lorena, Casanova, Isolda, López-Pousa, Antonio, Unzueta, Ugutz, Céspedes, María Virtudes, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon
Publicado 2022

Biparatopic Protein Nanoparticles for the Precision Therapy of CXCR4(+) Cancers

por Cano-Garrido, Olivia, Álamo, Patricia, Sánchez-García, Laura, Falgàs, Aïda, Sánchez-Chardi, Alejandro, Serna, Naroa, Parladé, Eloi, Unzueta, Ugutz, Roldán, Mònica, Voltà-Durán, Eric, Casanova, Isolda, Villaverde, Antonio, Mangues, Ramón, Vázquez, Esther
Publicado 2021

CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma

por Rioja-Blanco, Elisa, Arroyo-Solera, Irene, Álamo, Patricia, Casanova, Isolda, Gallardo, Alberto, Unzueta, Ugutz, Serna, Naroa, Sánchez-García, Laura, Quer, Miquel, Villaverde, Antonio, Vázquez, Esther, León, Xavier, Alba-Castellón, Lorena, Mangues, Ramon
Publicado 2022

A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model

por Rioja-Blanco, Elisa, Gallardo, Alberto, Arroyo-Solera, Irene, Álamo, Patricia, Casanova, Isolda, Unzueta, Ugutz, Serna, Naroa, Sánchez-García, Laura, Quer, Miquel, Villaverde, Antonio, Vázquez, Esther, León, Xavier, Alba-Castellón, Lorena, Mangues, Ramon
Publicado 2022

Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4(+) head and neck squamous cell carcinoma tumors

por Rioja-Blanco, Elisa, Arroyo-Solera, Irene, Álamo, Patricia, Casanova, Isolda, Gallardo, Alberto, Unzueta, Ugutz, Serna, Naroa, Sánchez-García, Laura, Quer, Miquel, Villaverde, Antonio, Vázquez, Esther, Mangues, Ramon, Alba-Castellón, Lorena, León, Xavier
Publicado 2022

Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles

por Álamo, Patricia, Pallarès, Victor, Céspedes, María Virtudes, Falgàs, Aïda, Sanchez, Julieta M., Serna, Naroa, Sánchez-García, Laura, Voltà-Duràn, Eric, Morris, Gordon A., Sánchez-Chardi, Alejandro, Casanova, Isolda, Mangues, Ramón, Vazquez, Esther, Villaverde, Antonio, Unzueta, Ugutz
Publicado 2020

Efficient Delivery of Antimicrobial Peptides in an Innovative, Slow-Release Pharmacological Formulation

por Serna, Naroa, López-Laguna, Hèctor, Aceituno, Patricia, Rojas-Peña, Mauricio, Parladé, Eloi, Voltà-Durán, Eric, Martínez-Torró, Carlos, Sánchez, Julieta M., Di Somma, Angela, Carratalá, Jose Vicente, Livieri, Andrea L., Ferrer-Miralles, Neus, Vázquez, Esther, Unzueta, Ugutz, Roher, Nerea, Villaverde, Antonio
Publicado 2023

Biofabrication of functional protein nanoparticles through simple His-tag engineering

por López-Laguna, Hèctor, Sánchez, Julieta M., Carratalá, José Vicente, Rojas-Peña, Mauricio, Sánchez-García, Laura, Parladé, Eloi, Sánchez-Chardi, Alejandro, Voltà-Durán, Eric, Serna, Naroa, Cano-Garrido, Olivia, Flores, Sandra, Ferrer-Miralles, Neus, Nolan, Verónica, de Marco, Ario, Roher, Nerea, Unzueta, Ugutz, Vazquez, Esther, Villaverde, Antonio
Publicado 2021