The cytosolic iron–sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors

por Redwood, Abena B., Zhang, Xiaomei, Seth, Sahil B., Ge, Zhongqi, Bindeman, Wendy E., Zhou, Xinhui, Sinha, Vidya C., Heffernan, Timothy P., Piwnica-Worms, Helen
Publicado 2021

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

por deCarvalho, Ana C., Kim, Hoon, Poisson, Laila M., Winn, Mary E., Mueller, Claudius, Cherba, David, Koeman, Julie, Seth, Sahil, Protopopov, Alexei, Felicella, Michelle, Zheng, Siyuan, Multani, Asha, Jiang, Yongying, Zhang, Jianhua, Nam, Do-Hyun, Petricoin, Emanuel F., Chin, Lynda, Mikkelsen, Tom, Verhaak, Roel G.W.
Publicado 2018

High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer

por Echeverria, Gloria V., Powell, Emily, Seth, Sahil, Ge, Zhongqi, Carugo, Alessandro, Bristow, Christopher, Peoples, Michael, Robinson, Frederick, Qiu, Huan, Shao, Jiansu, Jeter-Jones, Sabrina L., Zhang, Xiaomei, Ramamoorthy, Vandhana, Cai, Shirong, Wu, Wenhui, Draetta, Giulio, Moulder, Stacy L., Symmans, William F., Chang, Jeffrey T., Heffernan, Timothy P., Piwnica-Worms, Helen
Publicado 2018

Global impact of somatic structural variation on the DNA methylome of human cancers

por Zhang, Yiqun, Yang, Lixing, Kucherlapati, Melanie, Hadjipanayis, Angela, Pantazi, Angeliki, Bristow, Christopher A., Lee, Eunjung Alice, Mahadeshwar, Harshad S., Tang, Jiabin, Zhang, Jianhua, Seth, Sahil, Lee, Semin, Ren, Xiaojia, Song, Xingzhi, Sun, Huandong, Seidman, Jonathan, Luquette, Lovelace J., Xi, Ruibin, Chin, Lynda, Protopopov, Alexei, Park, Peter J., Kucherlapati, Raju, Creighton, Chad J.
Publicado 2019

Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function

por Kumar, Manish, Molkentine, David, Molkentine, Jessica, Bridges, Kathleen, Xie, Tongxin, Yang, Liangpeng, Hefner, Andrew, Gao, Meng, Bahri, Reshub, Dhawan, Annika, Frederick, Mitchell J., Seth, Sahil, Abdelhakiem, Mohamed, Beadle, Beth M., Johnson, Faye, Wang, Jing, Shen, Li, Heffernan, Timothy, Sheth, Aakash, Ferris, Robert L., Myers, Jeffrey N., Pickering, Curtis R., Skinner, Heath D.
Publicado 2021

OTME-23. Single-cell transcriptomic and epigenomic immune landscape of isocitrate dehydrogenase stratified human gliomas

por Gupta, Pravesh, Dang, Minghao, Hao, Dapeng, Bojja, Krishna, Tran, Tuan M, Shehwana, Huma, Kamiya-Matsuoka, Carlos, Li, Jianzhuo, Audia, Alessandra, Kassab, Cynthia, Ott, Martina, Gumin, Joy, Alenazy, Sanaalarab, Goldman, Alicia, Seth, Sahil A, Maheshwari, Atul, Balasubramaniyan, Veerakumar, Vaillant, Brian, de Groot, John F, Lang, Frederick F, Iavarone, Antonio, Navin, Nicholas E, Heimberger, Amy B, Wang, Linghua, Bhat, Krishna P
Publicado 2021

Prognostic Impact of High Baseline Stromal Tumor-Infiltrating Lymphocytes in the Absence of Pathologic Complete Response in Early-Stage Triple-Negative Breast Cancer

por Abuhadra, Nour, Sun, Ryan, Litton, Jennifer K., Rauch, Gaiane M., Yam, Clinton, Chang, Jeffrey T., Seth, Sahil, Bassett, Roland, Lim, Bora, Thompson, Alastair M., Mittendorf, Elizabeth, Adrada, Beatriz E., Damodaran, Senthil, White, Jason, Ravenberg, Elizabeth, Candelaria, Rosalind, Arun, Banu, Ueno, Naoto T., Santiago, Lumarie, Saleem, Sadia, Abouharb, Sausan, Murthy, Rashmi K., Ibrahim, Nuhad, Sahin, Aysegul A., Valero, Vicente, Symmans, William Fraser, Tripathy, Debu, Moulder, Stacy, Huo, Lei
Publicado 2022

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

por Hart, Traver, Tong, Amy Hin Yan, Chan, Katie, Van Leeuwen, Jolanda, Seetharaman, Ashwin, Aregger, Michael, Chandrashekhar, Megha, Hustedt, Nicole, Seth, Sahil, Noonan, Avery, Habsid, Andrea, Sizova, Olga, Nedyalkova, Lyudmila, Climie, Ryan, Tworzyanski, Leanne, Lawson, Keith, Sartori, Maria Augusta, Alibeh, Sabriyeh, Tieu, David, Masud, Sanna, Mero, Patricia, Weiss, Alexander, Brown, Kevin R., Usaj, Matej, Billmann, Maximilian, Rahman, Mahfuzur, Costanzo, Michael, Myers, Chad L., Andrews, Brenda J., Boone, Charles, Durocher, Daniel, Moffat, Jason
Publicado 2017

Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma

por Puca, Francesca, Yu, Fei, Bartolacci, Caterina, Pettazzoni, Piergiorgio, Carugo, Alessandro, Huang-Hobbs, Emmet, Liu, Jintan, Zanca, Ciro, Carbone, Federica, Del Poggetto, Edoardo, Gumin, Joy, Dasgupta, Pushan, Seth, Sahil, Srinivasan, Sanjana, Lang, Frederick F., Sulman, Erik P., Lorenzi, Philip L., Tan, Lin, Shan, Mengrou, Tolstyka, Zachary P., Kachman, Maureen, Zhang, Li, Gao, Sisi, Deem, Angela K., Genovese, Giannicola, Scaglioni, Pier Paolo, Lyssiotis, Costas A., Viale, Andrea, Draetta, Giulio F.
Publicado 2021

PTEN in triple-negative breast carcinoma: protein expression and genomic alteration in pretreatment and posttreatment specimens

por Chen, Hui, Ding, Qingqing, Khazai, Laila, Zhao, Li, Damodaran, Senthil, Litton, Jennifer K., Rauch, Gaiane M., Yam, Clinton, Chang, Jeffrey T., Seth, Sahil, Lim, Bora, Thompson, Alastair M., Mittendorf, Elizabeth A., Adrada, Beatriz, Virani, Kiran, White, Jason B., Ravenberg, Elizabeth, Song, Xingzhi, Candelaria, Rosalind, Arun, Banu, Ueno, Naoto T., Santiago, Lumarie, Saleem, Sadia, Abouharb, Sausan, Murthy, Rashmi K., Ibrahim, Nuhad, Routbort, Mark J., Sahin, Aysegul, Valero, Vicente, Symmans, William Fraser, Tripathy, Debu, Wang, Wei-Lien, Moulder, Stacy, Huo, Lei
Publicado 2023

A functional genomic approach to actionable gene fusions for precision oncology

por Li, Jun, Lu, Hengyu, Ng, Patrick Kwok-Shing, Pantazi, Angeliki, Ip, Carman Ka Man, Jeong, Kang Jin, Amador, Bianca, Tran, Richard, Tsang, Yiu Huen, Yang, Lixing, Song, Xingzhi, Dogruluk, Turgut, Ren, Xiaojia, Hadjipanayis, Angela, Bristow, Christopher A., Lee, Semin, Kucherlapati, Melanie, Parfenov, Michael, Tang, Jiabin, Seth, Sahil, Mahadeshwar, Harshad S., Mojumdar, Kamalika, Zeng, Dong, Zhang, Jianhua, Protopopov, Alexei, Seidman, Jonathan G., Creighton, Chad J., Lu, Yiling, Sahni, Nidhi, Shaw, Kenna R., Meric-Bernstam, Funda, Futreal, Andrew, Chin, Lynda, Scott, Kenneth L., Kucherlapati, Raju, Mills, Gordon B., Liang, Han
Publicado 2022

Syndecan1 is a critical mediator of macropinocytosis in pancreatic cancer

por Yao, Wantong, Rose, Johnathon L., Wang, Wei, Seth, Sahil, Jiang, Hong, Taguchi, Ayumu, Liu, Jintan, Yan, Liang, Kapoor, Avnish, Hou, Pingping, Chen, Ziheng, Wang, Qiuyun, Nezi, Luigi, Xu, Zhaohui, Yao, Jun, Hu, Baoli, Pettazzoni, Piergiorgio F., Ho, I Lin, Feng, Ningping, Ramamoorthy, Vandhana, Jiang, Shan, Deng, Pingna, Ma, Grace J., Den, Peter, Tan, Zhi, Zhang, Shu Xing, Wang, Huamin, Wang, Alan Y., Deem, Angela K., Fleming, Jason B., Carugo, Alessandro, Heffernan, Timothy P., Maitra, Anirban, Viale, Andrea, Ying, Haoqiang, Hanash, Samir, DePinho, Ronald A., Draetta, Giulio F.
Publicado 2019

Genomic heterogeneity of multiple synchronous lung cancer

por Liu, Yu, Zhang, Jianjun, Li, Lin, Yin, Guangliang, Zhang, Jianhua, Zheng, Shan, Cheung, Hannah, Wu, Ning, Lu, Ning, Mao, Xizeng, Yang, Longhai, Zhang, Jiexin, Zhang, Li, Seth, Sahil, Chen, Huang, Song, Xingzhi, Liu, Kan, Xie, Yongqiang, Zhou, Lina, Zhao, Chuanduo, Han, Naijun, Chen, Wenting, Zhang, Susu, Chen, Longyun, Cai, Wenjun, Li, Lin, Shen, Miaozhong, Xu, Ningzhi, Cheng, Shujun, Yang, Huanming, Lee, J. Jack, Correa, Arlene, Fujimoto, Junya, Behrens, Carmen, Chow, Chi-Wan, William, William N., Heymach, John V., Hong, Waun Ki, Swisher, Stephen, Wistuba, Ignacio I., Wang, Jun, Lin, Dongmei, Liu, Xiangyang, Futreal, P. Andrew, Gao, Yanning
Publicado 2016

Recurrent PTPRB and PLCG1 mutations in angiosarcoma

por Behjati, Sam, Tarpey, Patrick S, Sheldon, Helen, Martincorena, Inigo, Van Loo, Peter, Gundem, Gunes, Wedge, David C, Ramakrishna, Manasa, Cooke, Susanna L, Pillay, Nischalan, Vollan, Hans Kristian M, Papaemmanuil, Elli, Koss, Hans, Bunney, Tom D, Hardy, Claire, Joseph, Olivia R, Martin, Sancha, Mudie, Laura, Butler, Adam, Teague, Jon W, Patil, Meena, Steers, Graham, Cao, Yu, Gumbs, Curtis, Ingram, Davis, Lazar, Alexander J, Little, Latasha, Mahadeshwar, Harshad, Protopopov, Alexei, Al Sannaa, Ghadah A, Seth, Sahil, Song, Xingzhi, Tang, Jiabin, Zhang, Jianhua, Ravi, Vinod, Torres, Keila E, Khatri, Bhavisha, Halai, Dina, Roxanis, Ioannis, Baumhoer, Daniel, Tirabosco, Roberto, Amary, M Fernanda, Boshoff, Chris, McDermott, Ultan, Katan, Matilda, Stratton, Michael R, Futreal, P Andrew, Flanagan, Adrienne M, Harris, Adrian, Campbell, Peter J
Publicado 2014

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing

por Alioto, Tyler S., Buchhalter, Ivo, Derdak, Sophia, Hutter, Barbara, Eldridge, Matthew D., Hovig, Eivind, Heisler, Lawrence E., Beck, Timothy A., Simpson, Jared T., Tonon, Laurie, Sertier, Anne-Sophie, Patch, Ann-Marie, Jäger, Natalie, Ginsbach, Philip, Drews, Ruben, Paramasivam, Nagarajan, Kabbe, Rolf, Chotewutmontri, Sasithorn, Diessl, Nicolle, Previti, Christopher, Schmidt, Sabine, Brors, Benedikt, Feuerbach, Lars, Heinold, Michael, Gröbner, Susanne, Korshunov, Andrey, Tarpey, Patrick S., Butler, Adam P., Hinton, Jonathan, Jones, David, Menzies, Andrew, Raine, Keiran, Shepherd, Rebecca, Stebbings, Lucy, Teague, Jon W., Ribeca, Paolo, Giner, Francesc Castro, Beltran, Sergi, Raineri, Emanuele, Dabad, Marc, Heath, Simon C., Gut, Marta, Denroche, Robert E., Harding, Nicholas J., Yamaguchi, Takafumi N., Fujimoto, Akihiro, Nakagawa, Hidewaki, Quesada, Víctor, Valdés-Mas, Rafael, Nakken, Sigve, Vodák, Daniel, Bower, Lawrence, Lynch, Andrew G., Anderson, Charlotte L., Waddell, Nicola, Pearson, John V., Grimmond, Sean M., Peto, Myron, Spellman, Paul, He, Minghui, Kandoth, Cyriac, Lee, Semin, Zhang, John, Létourneau, Louis, Ma, Singer, Seth, Sahil, Torrents, David, Xi, Liu, Wheeler, David A., López-Otín, Carlos, Campo, Elías, Campbell, Peter J., Boutros, Paul C., Puente, Xose S., Gerhard, Daniela S., Pfister, Stefan M., McPherson, John D., Hudson, Thomas J., Schlesner, Matthias, Lichter, Peter, Eils, Roland, Jones, David T. W., Gut, Ivo G.
Publicado 2015