Testing Chemical Safety: What Is Needed to Ensure the Widespread Application of Non-animal Approaches?

por Burden, Natalie, Sewell, Fiona, Chapman, Kathryn
Publicado 2015

Developing and testing a matrix to achieve ready-everyday nursing standards (RENS): an observational study protocol

por Ratsch, Angela, Sewell, Fiona, Pennington, Adrian
Publicado 2019

Opportunities to Apply the 3Rs in Safety Assessment Programs

por Sewell, Fiona, Edwards, Joanna, Prior, Helen, Robinson, Sally
Publicado 2016

Justification for species selection for pharmaceutical toxicity studies

por Prior, Helen, Haworth, Richard, Labram, Briony, Roberts, Ruth, Wolfreys, Alison, Sewell, Fiona
Publicado 2020

Refining Procedures within Regulatory Toxicology Studies: Improving Animal Welfare and Data

por Prior, Helen, Blunt, Hollie, Crossman, Lee, McGuire, Aidan, Stow, Ruth, Sewell, Fiona
Publicado 2021

Exploring the Definition of “Similar Toxicities”: Case Studies Illustrating Industry and Regulatory Interpretation of ICH S6(R1) for Long-Term Toxicity Studies in One or Two Specie...

por Prior, Helen, Clarke, David O, Jones, David, Salicru, Eleni, Schutten, Melissa M, Sewell, Fiona
Publicado 2022

International Consortium to Advance Cross‐Species Extrapolation of the Effects of Chemicals in Regulatory Toxicology

por LaLone, Carlie A., Basu, Niladri, Browne, Patience, Edwards, Stephen W., Embry, Michelle, Sewell, Fiona, Hodges, Geoff
Publicado 2021

Adverse Outcome Pathways can drive non-animal approaches for safety assessment

por Burden, Natalie, Sewell, Fiona, Andersen, Melvin E, Boobis, Alan, Chipman, J Kevin, Cronin, Mark T D, Hutchinson, Thomas H, Kimber, Ian, Whelan, Maurice
Publicado 2015

Challenges and opportunities for the future of monoclonal antibody development: Improving safety assessment and reducing animal use

por Sewell, Fiona, Chapman, Kathryn, Couch, Jessica, Dempster, Maggie, Heidel, Shawn, Loberg, Lise, Maier, Curtis, Maclachlan, Timothy K., Todd, Marque, van der Laan, Jan Willem
Publicado 2017

The future trajectory of adverse outcome pathways: a commentary

por Sewell, Fiona, Gellatly, Nichola, Beaumont, Maria, Burden, Natalie, Currie, Richard, de Haan, Lolke, Hutchinson, Thomas H., Jacobs, Miriam, Mahony, Catherine, Malcomber, Ian, Mehta, Jyotigna, Whale, Graham, Kimber, Ian
Publicado 2018

Investigating endocrine‐disrupting properties of chemicals in fish and amphibians: Opportunities to apply the 3Rs

por Burden, Natalie, Embry, Michelle R., Hutchinson, Thomas H., Lynn, Scott G., Maynard, Samuel K., Mitchell, Constance A., Pellizzato, Francesca, Sewell, Fiona, Thorpe, Karen L., Weltje, Lennart, Wheeler, James R.
Publicado 2021

Transforming the evaluation of agrochemicals

por Wolf, Douglas C, Bhuller, Yadvinder, Cope, Rhian, Corvaro, Marco, Currie, Richard A, Doe, John, Doi, Adriana, Hilton, Gina, Mehta, Jyotigna, Saltmiras, David, Sewell, Fiona, Trainer, Maria, Déglin, Sandrine E
Publicado 2022

Recommendations on dose level selection for repeat dose toxicity studies

por Sewell, Fiona, Corvaro, Marco, Andrus, Amanda, Burke, Jonathan, Daston, George, Delaney, Bryan, Domoradzki, Jeanne, Forlini, Carole, Green, Maia Louise, Hofmann, Thomas, Jäckel, Sven, Lee, Moung Sook, Temerowski, Michael, Whalley, Paul, Lewis, Richard
Publicado 2022

Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment

por Tan, Yu-Mei, Barton, Hugh A., Boobis, Alan, Brunner, Rachel, Clewell, Harvey, Cope, Rhian, Dawson, Jeffrey, Domoradzki, Jeanne, Egeghy, Peter, Gulati, Pankaj, Ingle, Brandall, Kleinstreuer, Nicole, Lowe, Kelly, Lowit, Anna, Mendez, Elizabeth, Miller, David, Minucci, Jeffrey, Nguyen, James, Paini, Alicia, Perron, Monique, Phillips, Katherine, Qian, Hua, Ramanarayanan, Tharacad, Sewell, Fiona, Villanueva, Philip, Wambaugh, John, Embry, Michelle
Publicado 2021