Increased In Vivo Exposure of N-(4-Hydroxyphenyl) Retinamide (4-HPR) to Achieve Plasma Concentrations Effective against Dengue Virus

por Martin, Alexander J., Shackleford, David M., Charman, Susan A., Wagstaff, Kylie M., Porter, Christopher J. H., Jans, David A.
Publicado 2023

The Anti-Inflammatory Drug Aspirin Does Not Protect Against Chemotherapy-Induced Memory Impairment by Paclitaxel in Mice

por Chang, Aeson, Chung, Ni-Chun, Lawther, Adam J., Ziegler, Alexandra I., Shackleford, David M., Sloan, Erica K., Walker, Adam K.
Publicado 2020

Discovery and Structure–Activity Relationships of Pyrrolone Antimalarials

por Murugesan, Dinakaran, Mital, Alka, Kaiser, Marcel, Shackleford, David M., Morizzi, Julia, Katneni, Kasiram, Campbell, Michael, Hudson, Alan, Charman, Susan A., Yeates, Clive, Gilbert, Ian H.
Publicado 2013

Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds

por Katneni, Kasiram, Pham, Thao, Saunders, Jessica, Chen, Gong, Patil, Rahul, White, Karen L., Abla, Nada, Chiu, Francis C. K., Shackleford, David M., Charman, Susan A.
Publicado 2018

Muscarinic M(5) receptors modulate ethanol seeking in rats

por Berizzi, Alice E., Perry, Christina J., Shackleford, David M., Lindsley, Craig W., Jones, Carrie K., Chen, Nicola A., Sexton, Patrick M., Christopoulos, Arthur, Langmead, Christopher J., Lawrence, Andrew J.
Publicado 2018

Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones

por Chen, Yizhe, Zhu, Fangyi, Hammill, Jared, Holbrook, Gloria, Yang, Lei, Freeman, Burgess, White, Karen L., Shackleford, David M., O’Loughlin, Kathleen G., Charman, Susan A., Mirsalis, Jon C., Guy, R. Kiplin
Publicado 2021

In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

por Schleiferböck, Sarah, Scheurer, Christian, Ihara, Masataka, Itoh, Isamu, Bathurst, Ian, Burrows, Jeremy N, Fantauzzi, Pascal, Lotharius, Julie, Charman, Susan A, Morizzi, Julia, Shackleford, David M, White, Karen L, Brun, Reto, Wittlin, Sergio
Publicado 2013

Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage

por Francisco, Amanda Fortes, Jayawardhana, Shiromani, Lewis, Michael D., White, Karen L., Shackleford, David M., Chen, Gong, Saunders, Jessica, Osuna-Cabello, Maria, Read, Kevin D., Charman, Susan A., Chatelain, Eric, Kelly, John M.
Publicado 2016

Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978)

por Wang, Chunkai, Zhao, Qingjie, Vargas, Mireille, Jones, Jeremy O., White, Karen L., Shackleford, David M., Chen, Gong, Saunders, Jessica, Ng, Alice C. F., Chiu, Francis C. K., Dong, Yuxiang, Charman, Susan A., Keiser, Jennifer, Vennerstrom, Jonathan L.
Publicado 2016

Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

por Dow, Geoffrey S, Milner, Erin, Bathurst, Ian, Bhonsle, Jayendra, Caridha, Diana, Gardner, Sean, Gerena, Lucia, Kozar, Michael, Lanteri, Charlotte, Mannila, Anne, McCalmont, William, Moon, Jay, Read, Kevin D, Norval, Suzanne, Roncal, Norma, Shackleford, David M, Sousa, Jason, Steuten, Jessica, White, Karen L, Zeng, Qiang, Charman, Susan A
Publicado 2011

Orally Bioavailable 6-Chloro-7-methoxy-4(1H)-quinolones Efficacious against Multiple Stages of Plasmodium

por Cross, R. Matthew, Flanigan, David L., Monastyrskyi, Andrii, LaCrue, Alexis N., Sáenz, Fabián E., Maignan, Jordany R., Mutka, Tina S., White, Karen L., Shackleford, David M., Bathurst, Ian, Fronczek, Frank R, Wojtas, Lukasz, Guida, Wayne C., Charman, Susan A., Burrows, Jeremy N., Kyle, Dennis E., Manetsch, Roman
Publicado 2014

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity

por Kokkonda, Sreekanth, El Mazouni, Farah, White, Karen L., White, John, Shackleford, David M., Lafuente-Monasterio, Maria Jose, Rowland, Paul, Manjalanagara, Krishne, Joseph, Jayan T., Garcia-Pérez, Adolfo, Fernandez, Jorge, Gamo, Francisco Javier, Waterson, David, Burrows, Jeremy N., Palmer, Michael J., Charman, Susan A., Rathod, Pradipsinh K., Phillips, Margaret A.
Publicado 2018

Two Analogues of Fenarimol Show Curative Activity in an Experimental Model of Chagas Disease

por Keenan, Martine, Chaplin, Jason H., Alexander, Paul W., Abbott, Michael J., Best, Wayne M., Khong, Andrea, Botero, Adriana, Perez, Catherine, Cornwall, Scott, Thompson, R. Andrew, White, Karen L., Shackleford, David M., Koltun, Maria, Chiu, Francis C. K., Morizzi, Julia, Ryan, Eileen, Campbell, Michael, von Geldern, Thomas W., Scandale, Ivan, Chatelain, Eric, Charman, Susan A.
Publicado 2013

An in vitro toolbox to accelerate anti-malarial drug discovery and development

por Charman, Susan A., Andreu, Alice, Barker, Helena, Blundell, Scott, Campbell, Anna, Campbell, Michael, Chen, Gong, Chiu, Francis C. K., Crighton, Elly, Katneni, Kasiram, Morizzi, Julia, Patil, Rahul, Pham, Thao, Ryan, Eileen, Saunders, Jessica, Shackleford, David M., White, Karen L., Almond, Lisa, Dickins, Maurice, Smith, Dennis A., Moehrle, Joerg J., Burrows, Jeremy N., Abla, Nada
Publicado 2020

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease

por Finkelstein, David I., Billings, Jessica L., Adlard, Paul A., Ayton, Scott, Sedjahtera, Amelia, Masters, Colin L., Wilkins, Simon, Shackleford, David M., Charman, Susan A., Bal, Wojciech, Zawisza, Izabela A, Kurowska, Ewa, Gundlach, Andrew L., Ma, Sheri, Bush, Ashley I., Hare, Dominic J., Doble, Philip A., Crawford, Simon, Gautier, Elisabeth CL., Parsons, Jack, Huggins, Penny, Barnham, Kevin J., Cherny, Robert A.
Publicado 2017

Correction to: The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease

por Finkelstein, David I., Billings, Jessica L., Adlard, Paul A., Ayton, Scott, Sedjahtera, Amelia, Masters, Colin L., Wilkins, Simon, Shackleford, David M., Charman, Susan A., Bal, Wojciech, Zawisza, Izabela A., Kurowska, Ewa, Gundlach, Andrew L., Ma, Sheri, Bush, Ashley I., Hare, Dominic J., Doble, Philip A., Crawford, Simon, Gautier, Elisabeth C. L., Parsons, Jack, Huggins, Penny, Barnham, Kevin J., Cherny, Robert A.
Publicado 2021

PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective

por Orozco Morales, M. Lizeth, Rinaldi, Catherine A., de Jong, Emma, Lansley, Sally M., Gummer, Joel P.A., Olasz, Bence, Nambiar, Shabarinath, Hope, Danika E., Casey, Thomas H., Lee, Y. C. Gary, Leslie, Connull, Nealon, Gareth, Shackleford, David M., Powell, Andrew K., Grimaldi, Marina, Balaguer, Patrick, Zemek, Rachael M., Bosco, Anthony, Piggott, Matthew J., Vrielink, Alice, Lake, Richard A., Lesterhuis, W. Joost
Publicado 2021

Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors

por Okaniwa, Masanori, Shibata, Akira, Ochida, Atsuko, Akao, Yuichiro, White, Karen L., Shackleford, David M., Duffy, Sandra, Lucantoni, Leonardo, Dey, Sumanta, Striepen, Josefine, Yeo, Tomas, Mok, Sachel, Aguiar, Anna Caroline C., Sturm, Angelika, Crespo, Benigno, Sanz, Laura M., Churchyard, Alisje, Baum, Jake, Pereira, Dhelio B., Guido, Rafael V. C., Dechering, Koen J., Wittlin, Sergio, Uhlemann, Anne-Catrin, Fidock, David A., Niles, Jacquin C., Avery, Vicky M., Charman, Susan A., Laleu, Benoît
Publicado 2021

The hypoxia imaging agent Cu(II)(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease

por Hung, Lin W., Villemagne, Victor L., Cheng, Lesley, Sherratt, Nicki A., Ayton, Scott, White, Anthony R., Crouch, Peter J., Lim, SinChun, Leong, Su Ling, Wilkins, Simon, George, Jessica, Roberts, Blaine R., Pham, Chi L.L., Liu, Xiang, Chiu, Francis C.K., Shackleford, David M., Powell, Andrew K., Masters, Colin L., Bush, Ashley I., O’Keefe, Graeme, Culvenor, Janetta G., Cappai, Roberto, Cherny, Robert A., Donnelly, Paul S., Hill, Andrew F., Finkelstein, David I., Barnham, Kevin J.
Publicado 2012

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

por O'Neill, Paul M., Amewu, Richard K., Charman, Susan A., Sabbani, Sunil, Gnädig, Nina F., Straimer, Judith, Fidock, David A., Shore, Emma R., Roberts, Natalie L., Wong, Michael H.-L., Hong, W. David, Pidathala, Chandrakala, Riley, Chris, Murphy, Ben, Aljayyoussi, Ghaith, Gamo, Francisco Javier, Sanz, Laura, Rodrigues, Janneth, Cortes, Carolina Gonzalez, Herreros, Esperanza, Angulo-Barturén, Iñigo, Jiménez-Díaz, María Belén, Bazaga, Santiago Ferrer, Martínez-Martínez, María Santos, Campo, Brice, Sharma, Raman, Ryan, Eileen, Shackleford, David M., Campbell, Simon, Smith, Dennis A., Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N., Marfurt, Jutta, Palmer, Michael J., Copple, Ian M., Mercer, Amy E., Ruecker, Andrea, Delves, Michael J., Sinden, Robert E., Siegl, Peter, Davies, Jill, Rochford, Rosemary, Kocken, Clemens H. M., Zeeman, Anne-Marie, Nixon, Gemma L., Biagini, Giancarlo A., Ward, Stephen A.
Publicado 2017