Mosaic Drug Efflux Gene Sequences from Commensal Neisseria Can Lead to Low-Level Azithromycin Resistance Expressed by Neisseria gonorrhoeae Clinical Isolates

por Shafer, William M.
Publicado 2018

Taking the Gonococcus-Human Relationship to a Whole New Level: Implications for the Coevolution of Microbes and Humans

por Shafer, William M., Ohneck, Elizabeth A.
Publicado 2011

MtrR Control of a Transcriptional Regulatory Pathway in Neisseria meningitidis That Influences Expression of a Gene (nadA) Encoding a Vaccine Candidate

por Cloward, Jason M., Shafer, William M.
Publicado 2013

The Transcriptional Repressor, MtrR, of the mtrCDE Efflux Pump Operon of Neisseria gonorrhoeae Can Also Serve as an Activator of “off Target” Gene (glnE) Expression

por Johnson, Paul J. T., Shafer, William M.
Publicado 2015

Transcriptional regulation of a gonococcal gene encoding a virulence factor (L-lactate permease)

por Ayala, Julio C., Shafer, William M.
Publicado 2019

Dueling Regulatory Properties of a Transcriptional Activator (MtrA) and Repressor (MtrR) That Control Efflux Pump Gene Expression in Neisseria gonorrhoeae

por Zalucki, Yaramah M., Dhulipala, Vijaya, Shafer, William M.
Publicado 2012

Neisseria gonorrhoeae Modulates Iron-Limiting Innate Immune Defenses in Macrophages

por Zughaier, Susu M., Kandler, Justin L., Shafer, William M.
Publicado 2014

Transcriptional control of the gonococcal ompA gene by the MisR/MisS two-component regulatory system

por Holley, Concerta L., Ayala, Julio C., Shafer, William M.
Publicado 2020

Identification of a Neisseria gonorrhoeae Histone Deacetylase: Epigenetic Impact on Host Gene Expression

por Zughaier, Susu M., Rouquette-Loughlin, Corinne E., Shafer, William M.
Publicado 2020

Phosphoethanolamine Modification of Neisseria gonorrhoeae Lipid A Reduces Autophagy Flux in Macrophages

por Zughaier, Susu M., Kandler, Justin L., Balthazar, Jacqueline T., Shafer, William M.
Publicado 2015

The Human Host Defense Peptide LL-37 Interacts with Neisseria meningitidis Capsular Polysaccharides and Inhibits Inflammatory Mediators Release

por Zughaier, Susu M., Svoboda, Pavel, Pohl, Jan, Stephens, David S., Shafer, William M.
Publicado 2010

Structure-Function Relationships of the Neisserial EptA Enzyme Responsible for Phosphoethanolamine Decoration of Lipid A: Rationale for Drug Targeting

por Kahler, Charlene M., Nawrocki, K. L., Anandan, A., Vrielink, Alice, Shafer, William M.
Publicado 2018

Lipooligosaccharide Structure is an Important Determinant in the Resistance of Neisseria Gonorrhoeae to Antimicrobial Agents of Innate Host Defense

por Balthazar, Jacqueline T., Gusa, Asiya, Martin, Larry E., Choudhury, Biswa, Carlson, Russell, Shafer, William M.
Publicado 2011

Gonococcal Clinical Strains Bearing a Common gdhR Single Nucleotide Polymorphism That Results in Enhanced Expression of the Virulence Gene lctP Frequently Possess a mtrR Promoter M...

por Ayala, Julio C., Schmerer, Matthew W., Kersh, Ellen N., Unemo, Magnus, Shafer, William M.
Publicado 2022

Structural Basis of Peptide-Based Antimicrobial Inhibition of a Resistance-Nodulation-Cell Division Multidrug Efflux Pump

por Lyu, Meinan, Ayala, Julio C., Chirakos, Isabella, Su, Chih-Chia, Shafer, William M., Yu, Edward W.
Publicado 2022

Experimental Gonococcal Infection in Male Volunteers: Cumulative Experience with Neisseria gonorrhoeae Strains FA1090 and MS11mkC

por Hobbs, Marcia M., Sparling, P. Frederick, Cohen, Myron S., Shafer, William M., Deal, Carolyn D., Jerse, Ann E.
Publicado 2011

Could Dampening Expression of the Neisseria gonorrhoeae mtrCDE-Encoded Efflux Pump Be a Strategy To Preserve Currently or Resurrect Formerly Used Antibiotics To Treat Gonorrhea?

por Chen, Shaochun, Connolly, Kristie L., Rouquette-Loughlin, Corinne, D’Andrea, Alexander, Jerse, Ann E., Shafer, William M.
Publicado 2019

Genetic Resistance Determinants, In Vitro Time-Kill Curve Analysis and Pharmacodynamic Functions for the Novel Topoisomerase II Inhibitor ETX0914 (AZD0914) in Neisseria gonorrhoeae

por Foerster, Sunniva, Golparian, Daniel, Jacobsson, Susanne, Hathaway, Lucy J., Low, Nicola, Shafer, William M., Althaus, Christian L., Unemo, Magnus
Publicado 2015

Transcriptional activation of ompA in Neisseria gonorrhoeae mediated by the XRE family member protein NceR

por Holley, Concerta L., Dhulipala, Vijaya, Maurakis, Stavaros A., Greenawalt, Ashley Nicole, Read, Timothy D., Cornelissen, Cynthia N., Shafer, William M.
Publicado 2023

Genomic evolution of Neisseria gonorrhoeae since the preantibiotic era (1928–2013): antimicrobial use/misuse selects for resistance and drives evolution

por Golparian, Daniel, Harris, Simon R., Sánchez-Busó, Leonor, Hoffmann, Steen, Shafer, William M., Bentley, Stephen D., Jensen, Jörgen S., Unemo, Magnus
Publicado 2020