Learning from ancestors

por Hong, Suk ho, Shah, Neel H
Publicado 2019

Deep mutational analysis reveals functional trade-offs in the sequences of EGFR autophosphorylation sites

por Cantor, Aaron J., Shah, Neel H., Kuriyan, John
Publicado 2018

Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen

por Shah, Neel H, Löbel, Mark, Weiss, Arthur, Kuriyan, John
Publicado 2018

Extein Residues Play an Intimate Role in the Rate-Limiting Step of Protein Trans-Splicing

por Shah, Neel H., Eryilmaz, Ertan, Cowburn, David, Muir, Tom W.
Publicado 2013

Naturally Split Inteins Assemble through a “Capture and Collapse” Mechanism

por Shah, Neel H., Eryilmaz, Ertan, Cowburn, David, Muir, Tom W.
Publicado 2013

Structural and dynamical features of inteins and implications on protein splicing.

por Eryilmaz, Ertan, Shah, Neel H., Muir, Tom W., Cowburn, David
Publicado 2014

High-throughput profiling of sequence recognition by tyrosine kinases and SH2 domains using bacterial peptide display

por Li, Allyson, Voleti, Rashmi, Lee, Minhee, Gagoski, Dejan, Shah, Neel H
Publicado 2023

The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases

por Shah, Neel H., Amacher, Jeanine F., Nocka, Laura M., Kuriyan, John
Publicado 2018

Differences in the dynamics of the tandem‐SH2 modules of the Syk and ZAP‐70 tyrosine kinases

por Hobbs, Helen T., Shah, Neel H., Badroos, Jean M., Gee, Christine L., Marqusee, Susan, Kuriyan, John
Publicado 2021

Saturation mutagenesis of a predicted ancestral Syk‐family kinase

por Hobbs, Helen T., Shah, Neel H., Shoemaker, Sophie R., Amacher, Jeanine F., Marqusee, Susan, Kuriyan, John
Publicado 2022

The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain

por van Vlimmeren, Anne E., Voleti, Rashmi, Chartier, Cassandra A., Jiang, Ziyuan, Karandur, Deepti, Shah, Neel H.
Publicado 2023

Streamlined Expressed Protein Ligation Using Split Inteins

por Vila-Perelló, Miquel, Liu, Zhihua, Shah, Neel H., Willis, John A., Idoyaga, Juliana, Muir, Tom W.
Publicado 2012

Design of a Split Intein with Exceptional Protein Splicing Activity

por Stevens, Adam J., Brown, Zachary Z., Shah, Neel H., Sekar, Giridhar, Cowburn, David, Muir, Tom W.
Publicado 2016

Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT

por Lo, Wan-Lin, Shah, Neel H., Ahsan, Nagib, Horkova, Veronika, Stepanek, Ondrej, Salomon, Arthur R., Kuriyan, John, Weiss, Arthur
Publicado 2018

An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor

por Shah, Neel H, Wang, Qi, Yan, Qingrong, Karandur, Deepti, Kadlecek, Theresa A, Fallahee, Ian R, Russ, William P, Ranganathan, Rama, Weiss, Arthur, Kuriyan, John
Publicado 2016

Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination

por Lo, Wan-Lin, Shah, Neel H., Rubin, Sara A., Zhang, Weiguo, Horkova, Veronika, Fallahee, Ian R., Stepanek, Ondrej, Zon, Leonard I., Kuriyan, John, Weiss, Arthur
Publicado 2019

SEC-TMT facilitates quantitative differential analysis of protein interaction networks

por Doron-Mandel, Ella, Bokor, Benjamin J., Ma, Yanzhe, Street, Lena A., Tang, Lauren C., Abdou, Ahmed A., Shah, Neel H., Rosenberger, George A., Jovanovic, Marko
Publicado 2023

Deconstruction of the Ras switching cycle through saturation mutagenesis

por Bandaru, Pradeep, Shah, Neel H, Bhattacharyya, Moitrayee, Barton, John P, Kondo, Yasushi, Cofsky, Joshua C, Gee, Christine L, Chakraborty, Arup K, Kortemme, Tanja, Ranganathan, Rama, Kuriyan, John
Publicado 2017

A saturation-mutagenesis analysis of the interplay between stability and activation in Ras

por Hidalgo, Frank, Nocka, Laura M, Shah, Neel H, Gorday, Kent, Latorraca, Naomi R, Bandaru, Pradeep, Templeton, Sage, Lee, David, Karandur, Deepti, Pelton, Jeffrey G, Marqusee, Susan, Wemmer, David, Kuriyan, John
Publicado 2022

Prediction of protein–ligand binding affinity from sequencing data with interpretable machine learning

por Rube, H. Tomas, Rastogi, Chaitanya, Feng, Siqian, Kribelbauer, Judith F., Li, Allyson, Becerra, Basheer, Melo, Lucas A. N., Do, Bach Viet, Li, Xiaoting, Adam, Hammaad H., Shah, Neel H., Mann, Richard S., Bussemaker, Harmen J.
Publicado 2022