Targeting Ion Channels and Purkinje Neuron Intrinsic Membrane Excitability as a Therapeutic Strategy for Cerebellar Ataxia

por Huang, Haoran, Shakkottai, Vikram G.
Publicado 2023

Vulnerability of Human Cerebellar Neurons to Degeneration in Ataxia-Causing Channelopathies

por Bushart, David D., Shakkottai, Vikram G.
Publicado 2022

Dendritic potassium channel dysfunction may contribute to dendrite degeneration in spinocerebellar ataxia type 1

por Chopra, Ravi, Bushart, David D., Shakkottai, Vikram G.
Publicado 2018

Targeting potassium channels to treat cerebellar ataxia

por Bushart, David D., Chopra, Ravi, Singh, Vikrant, Murphy, Geoffrey G., Wulff, Heike, Shakkottai, Vikram G.
Publicado 2018

Multiple system atrophy pathology is associated with primary Sjögren’s syndrome

por Conway, Kyle S., Camelo-Piragua, Sandra, Fisher-Hubbard, Amanda, Perry, William R., Shakkottai, Vikram G., Venneti, Sriram
Publicado 2020

Preliminary Study of Vibrotactile Feedback during Home-Based Balance and Coordination Training in Individuals with Cerebellar Ataxia

por Jabri, Safa, Bushart, David D., Kinnaird, Catherine, Bao, Tian, Bu, Angel, Shakkottai, Vikram G., Sienko, Kathleen H.
Publicado 2022

Increased intrinsic membrane excitability is associated with hypertrophic olivary degeneration in spinocerebellar ataxia type 1

por Morrison, Logan M., Huang, Haoran, Handler, Hillary P., Fu, Min, Bushart, David D., Pappas, Samuel S., Orr, Harry T., Shakkottai, Vikram G.
Publicado 2023

Heat Shock Protein Beta-1 Modifies Anterior to Posterior Purkinje Cell Vulnerability in a Mouse Model of Niemann-Pick Type C Disease

por Chung, Chan, Elrick, Matthew J., Dell’Orco, James M., Qin, Zhaohui S., Kalyana-Sundaram, Shanker, Chinnaiyan, Arul M., Shakkottai, Vikram G., Lieberman, Andrew P.
Publicado 2016

Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD

por Schultz, Mark L., Krus, Kelsey L., Kaushik, Susmita, Dang, Derek, Chopra, Ravi, Qi, Ling, Shakkottai, Vikram G., Cuervo, Ana Maria, Lieberman, Andrew P.
Publicado 2018

Neuronal activity regulates Matrin 3 abundance and function in a calcium-dependent manner through calpain-mediated cleavage and calmodulin binding

por Malik, Ahmed M., Wu, Josephine J., Gillies, Christie A., Doctrove, Quinlan A., Li, Xingli, Huang, Haoran, Tank, Elizabeth H. M., Shakkottai, Vikram G., Barmada, Sami
Publicado 2023

Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1

por Chopra, Ravi, Bushart, David D, Cooper, John P, Yellajoshyula, Dhananjay, Morrison, Logan M, Huang, Haoran, Handler, Hillary P, Man, Luke J, Dansithong, Warunee, Scoles, Daniel R, Pulst, Stefan M, Orr, Harry T, Shakkottai, Vikram G
Publicado 2020

Vascular Risk Factors and Clinical Progression in Spinocerebellar Ataxias

por Lo, Raymond Y., Figueroa, Karla P., Pulst, Stefan M., Lin, Chi-Ying, Perlman, Susan, Wilmot, George, Gomez, Christopher M., Schmahmann, Jeremy, Paulson, Henry, Shakkottai, Vikram G., Ying, Sarah H., Zesiewicz, Theresa, Bushara, Khalaf, Geschwind, Michael, Xia, Guangbin, Subramony, S. H., Ashizawa, Tetsuo, Kuo, Sheng-Han
Publicado 2015

Postural Tremor and Ataxia Progression in Spinocerebellar Ataxias

por Gan, Shi-Rui, Wang, Jie, Figueroa, Karla P., Pulst, Stefan M., Tomishon, Darya, Lee, Danielle, Perlman, Susan, Wilmot, George, Gomez, Christopher M., Schmahmann, Jeremy, Paulson, Henry, Shakkottai, Vikram G., Ying, Sarah H., Zesiewicz, Theresa, Bushara, Khalaf, Geschwind, Michael D., Xia, Guangbin, Subramony, S. H., Ashizawa, Tetsuo, Kuo, Sheng-Han
Publicado 2017

Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann–Pick diseases

por Schultz, Mark L., Fawaz, Maria V., Azaria, Ruth D., Hollon, Todd C., Liu, Elaine A., Kunkel, Thaddeus J., Halseth, Troy A., Krus, Kelsey L., Ming, Ran, Morin, Emily E., McLoughlin, Hayley S., Bushart, David D., Paulson, Henry L., Shakkottai, Vikram G., Orringer, Daniel A., Schwendeman, Anna S., Lieberman, Andrew P.
Publicado 2019

Clinical characteristics of patients with spinocerebellar ataxias 1, 2, 3 and 6 in the US; a prospective observational study

por Ashizawa, Tetsuo, Figueroa, Karla P, Perlman, Susan L, Gomez, Christopher M, Wilmot, George R, Schmahmann, Jeremy D, Ying, Sarah H, Zesiewicz, Theresa A, Paulson, Henry L, Shakkottai, Vikram G, Bushara, Khalaf O, Kuo, Sheng-Han, Geschwind, Michael D, Xia, Guangbin, Mazzoni, Pietro, Krischer, Jeffrey P, Cuthbertson, David, Holbert, Amy Roberts, Ferguson, John H, Pulst, Stefan M, Subramony, SH
Publicado 2013

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

por Chia, Ruth, Sabir, Marya S., Bandres-Ciga, Sara, Saez-Atienzar, Sara, Reynolds, Regina H., Gustavsson, Emil, Walton, Ronald L., Ahmed, Sarah, Viollet, Coralie, Ding, Jinhui, Makarious, Mary B., Diez-Fairen, Monica, Portley, Makayla K., Shah, Zalak, Abramzon, Yevgeniya, Hernandez, Dena G., Blauwendraat, Cornelis, Stone, David J., Eicher, John, Parkkinen, Laura, Ansorge, Olaf, Clark, Lorraine, Honig, Lawrence S., Marder, Karen, Lemstra, Afina, St George-Hyslop, Peter, Londos, Elisabet, Morgan, Kevin, Lashley, Tammaryn, Warner, Thomas T., Jaunmuktane, Zane, Galasko, Douglas, Santana, Isabel, Tienari, Pentti J., Myllykangas, Liisa, Oinas, Minna, Cairns, Nigel J., Morris, John C., Halliday, Glenda M., Van Deerlin, Vivianna M., Trojanowski, John Q., Grassano, Maurizio, Calvo, Andrea, Mora, Gabriele, Canosa, Antonio, Floris, Gianluca, Bohannan, Ryan C., Brett, Francesca, Gan-Or, Ziv, Geiger, Joshua T., Moore, Anni, May, Patrick, Krüger, Rejko, Goldstein, David S., Lopez, Grisel, Tayebi, Nahid, Sidransky, Ellen, Norcliffe-Kaufmann, Lucy, Palma, Jose-Alberto, Kaufmann, Horacio, Shakkottai, Vikram G., Perkins, Matthew, Newell, Kathy L., Gasser, Thomas, Schulte, Claudia, Landi, Francesco, Salvi, Erika, Cusi, Daniele, Masliah, Eliezer, Kim, Ronald C., Caraway, Chad A., Monuki, Edwin S., Brunetti, Maura, Dawson, Ted M., Rosenthal, Liana S., Albert, Marilyn S., Pletnikova, Olga, Troncoso, Juan C., Flanagan, Margaret E., Mao, Qinwen, Bigio, Eileen H., Rodríguez-Rodríguez, Eloy, Infante, Jon, Lage, Carmen, González-Aramburu, Isabel, Sanchez-Juan, Pascual, Ghetti, Bernardino, Keith, Julia, Black, Sandra E., Masellis, Mario, Rogaeva, Ekaterina, Duyckaerts, Charles, Brice, Alexis, Lesage, Suzanne, Xiromerisiou, Georgia, Barrett, Matthew J., Tilley, Bension S., Gentleman, Steve, Logroscino, Giancarlo, Serrano, Geidy E., Beach, Thomas G., McKeith, Ian G., Thomas, Alan J., Attems, Johannes, Morris, Christopher M., Palmer, Laura, Love, Seth, Troakes, Claire, Al-Sarraj, Safa, Hodges, Angela K., Aarsland, Dag, Klein, Gregory, Kaiser, Scott M., Woltjer, Randy, Pastor, Pau, Bekris, Lynn M., Leverenz, James B., Besser, Lilah M., Kuzma, Amanda, Renton, Alan E., Goate, Alison, Bennett, David A., Scherzer, Clemens R., Morris, Huw R., Ferrari, Raffaele, Albani, Diego, Pickering-Brown, Stuart, Faber, Kelley, Kukull, Walter A., Morenas-Rodriguez, Estrella, Lleó, Alberto, Fortea, Juan, Alcolea, Daniel, Clarimon, Jordi, Nalls, Mike A., Ferrucci, Luigi, Resnick, Susan M., Tanaka, Toshiko, Foroud, Tatiana M., Graff-Radford, Neill R., Wszolek, Zbigniew K., Ferman, Tanis, Boeve, Bradley F., Hardy, John A., Topol, Eric J., Torkamani, Ali, Singleton, Andrew B., Ryten, Mina, Dickson, Dennis W., Chiò, Adriano, Ross, Owen A., Gibbs, J. Raphael, Dalgard, Clifton L., Traynor, Bryan J., Scholz, Sonja W.
Publicado 2021