Discovery of Small-Molecule Modulators of the Sonic Hedgehog Pathway

por Schaefer, Giannina I., Perez, José R., Duvall, Jeremy R., Stanton, Benjamin Z., Shamji, Alykhan F., Schreiber, Stuart L.
Publicado 2013

A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma

por Yuan, Yuan, Wang, Qiu, Paulk, Joshiawa, Kubicek, Stefan, Kemp, Melissa M., Adams, Drew J., Shamji, Alykhan F., Wagner, Bridget K., Schreiber, Stuart L.
Publicado 2012

Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death

por Adams, Drew J., Boskovic, Zarko V., Theriault, Jimmy R., Wang, Alex J., Stern, Andrew M., Wagner, Bridget K., Shamji, Alykhan F., Schreiber, Stuart L.
Publicado 2013

NAMPT Is the Cellular Target of STF-31-Like Small-Molecule Probes

por Adams, Drew J., Ito, Daisuke, Rees, Matthew G., Seashore-Ludlow, Brinton, Puyang, Xiaoling, Ramos, Alex H., Cheah, Jaime H., Clemons, Paul A., Warmuth, Markus, Zhu, Ping, Shamji, Alykhan F., Schreiber, Stuart L.
Publicado 2014

Discovery of a Small-Molecule Probe for V-ATPase Function

por Aldrich, Leslie N., Kuo, Szu-Yu, Castoreno, Adam B., Goel, Gautam, Kuballa, Petric, Rees, Matthew G., Seashore-Ludlow, Brinton A., Cheah, Jaime H., Latorre, Isabel J., Schreiber, Stuart L., Shamji, Alykhan F., Xavier, Ramnik J.
Publicado 2015

Selective killing of cancer cells with a small molecule targeting stress response to ROS

por Raj, Lakshmi, Ide, Takao, Gurkar, Aditi U, Foley, Michael, Schenone, Monica, Li, Xiaoyu, Tolliday, Nicola J., Golub, Todd R., Carr, Steven A., Shamji, Alykhan F., Stern, Andrew M., Mandinova, Anna, Schreiber, Stuart L., Lee, Sam W.
Publicado 2011

Multiplex Cytological Profiling Assay to Measure Diverse Cellular States

por Gustafsdottir, Sigrun M., Ljosa, Vebjorn, Sokolnicki, Katherine L., Anthony Wilson, J., Walpita, Deepika, Kemp, Melissa M., Petri Seiler, Kathleen, Carrel, Hyman A., Golub, Todd R., Schreiber, Stuart L., Clemons, Paul A., Carpenter, Anne E., Shamji, Alykhan F.
Publicado 2013

A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay

por Bray, Mark-Anthony, Gustafsdottir, Sigrun M, Rohban, Mohammad H, Singh, Shantanu, Ljosa, Vebjorn, Sokolnicki, Katherine L, Bittker, Joshua A, Bodycombe, Nicole E, Dančík, Vlado, Hasaka, Thomas P, Hon, Cindy S, Kemp, Melissa M, Li, Kejie, Walpita, Deepika, Wawer, Mathias J, Golub, Todd R, Schreiber, Stuart L, Clemons, Paul A, Shamji, Alykhan F, Carpenter, Anne E
Publicado 2017

Identification of cancer cytotoxic modulators of PDE3A by predictive chemogenomics

por de Waal, Luc, Lewis, Timothy A., Rees, Matthew G., Tsherniak, Aviad, Wu, Xiaoyun, Choi, Peter S., Gechijian, Lara, Hartigan, Christina, Faloon, Patrick W., Hickey, Mark J., Tolliday, Nicola, Carr, Steven A., Clemons, Paul A., Munoz, Benito, Wagner, Bridget K., Shamji, Alykhan F., Koehler, Angela N., Schenone, Monica, Burgin, Alex B., Schreiber, Stuart L., Greulich, Heidi, Meyerson, Matthew
Publicado 2015

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

por Yu, Channing, Mannan, Aristotle M., Yvone, Griselda Metta, Ross, Kenneth N., Zhang, Yan-Ling, Marton, Melissa A., Taylor, Bradley R., Crenshaw, Andrew, Gould, Joshua Z., Tamayo, Pablo, Weir, Barbara A., Tsherniak, Aviad, Wong, Bang, Garraway, Levi A., Shamji, Alykhan F., Palmer, Michelle A., Foley, Michael A., Winckler, Wendy, Schreiber, Stuart L., Kung, Andrew L., Golub, Todd R.
Publicado 2016

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

por Khor, Bernard, Gagnon, John D, Goel, Gautam, Roche, Marly I, Conway, Kara L, Tran, Khoa, Aldrich, Leslie N, Sundberg, Thomas B, Paterson, Alison M, Mordecai, Scott, Dombkowski, David, Schirmer, Melanie, Tan, Pauline H, Bhan, Atul K, Roychoudhuri, Rahul, Restifo, Nicholas P, O'Shea, John J, Medoff, Benjamin D, Shamji, Alykhan F, Schreiber, Stuart L, Sharpe, Arlene H, Shaw, Stanley Y, Xavier, Ramnik J
Publicado 2015

Correlating chemical sensitivity and basal gene expression reveals mechanism of action

por Rees, Matthew G., Seashore-Ludlow, Brinton, Cheah, Jaime H., Adams, Drew J., Price, Edmund V., Gill, Shubhroz, Javaid, Sarah, Coletti, Matthew E., Jones, Victor L., Bodycombe, Nicole E., Soule, Christian K., Alexander, Benjamin, Li, Ava, Montgomery, Philip, Kotz, Joanne D., Hon, C. Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Haber, Daniel A., Clish, Clary B., Bittker, Joshua A., Palmer, Michelle, Wagner, Bridget K., Clemons, Paul A., Shamji, Alykhan F., Schreiber, Stuart L.
Publicado 2015

Integrated genetic and pharmacologic interrogation of rare cancers

por Hong, Andrew L., Tseng, Yuen-Yi, Cowley, Glenn S., Jonas, Oliver, Cheah, Jaime H., Kynnap, Bryan D., Doshi, Mihir B., Oh, Coyin, Meyer, Stephanie C., Church, Alanna J., Gill, Shubhroz, Bielski, Craig M., Keskula, Paula, Imamovic, Alma, Howell, Sara, Kryukov, Gregory V., Clemons, Paul A., Tsherniak, Aviad, Vazquez, Francisca, Crompton, Brian D., Shamji, Alykhan F., Rodriguez-Galindo, Carlos, Janeway, Katherine A., Roberts, Charles W. M., Stegmaier, Kimberly, van Hummelen, Paul, Cima, Michael J., Langer, Robert S., Garraway, Levi A., Schreiber, Stuart L., Root, David E., Hahn, William C., Boehm, Jesse S.
Publicado 2016