Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

por Shanks, Emma J., Ong, Han B., Robinson, David A., Thompson, Stephen, Sienkiewicz, Natasha, Fairlamb, Alan H., Frearson, Julie A.
Publicado 2010

Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

por Patterson, Stephen, Jones, Deuan C, Shanks, Emma J, Frearson, Julie A, Gilbert, Ian H, Wyatt, Paul G, Fairlamb, Alan H
Publicado 2009

A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor

por Hewit, Kay, Sandilands, Emma, Martinez, Rafael Sanchez, James, Daniel, Leung, Hing Y., Bryant, David M., Shanks, Emma, Markert, Elke K.
Publicado 2018

The phospholipid PI(3,4)P(2) is an apical identity determinant

por Román-Fernández, Álvaro, Roignot, Julie, Sandilands, Emma, Nacke, Marisa, Mansour, Mohammed A., McGarry, Lynn, Shanks, Emma, Mostov, Keith E., Bryant, David M.
Publicado 2018

Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment

por Rushworth, Linda K., Hewit, Kay, Munnings-Tomes, Sophie, Somani, Sukrut, James, Daniel, Shanks, Emma, Dufès, Christine, Straube, Anne, Patel, Rachana, Leung, Hing Y.
Publicado 2019

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallo...

por Patterson, Stephen, Alphey, Magnus S., Jones, Deuan C., Shanks, Emma J., Street, Ian P., Frearson, Julie A., Wyatt, Paul G., Gilbert, Ian H., Fairlamb, Alan H.
Publicado 2011

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines

por Gardner, Nicola J., Gillespie, Peter J., Carrington, Jamie T., Shanks, Emma J., McElroy, Stuart P., Haagensen, Emma J., Frearson, Julie A., Woodland, Andrew, Blow, J. Julian
Publicado 2017

Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

por Spinks, Daniel, Shanks, Emma J, Cleghorn, Laura A T, McElroy, Stuart, Jones, Deuan, James, Daniel, Fairlamb, Alan H, Frearson, Julie A, Wyatt, Paul G, Gilbert, Ian H
Publicado 2009

Identification of a Clinically Relevant Signature for Early Progression in KRAS-Driven Lung Adenocarcinoma

por Neidler, Sarah, Kruspig, Björn, Hewit, Kay, Monteverde, Tiziana, Gyuraszova, Katarina, Braun, Attila, Clark, William, James, Daniel, Hedley, Ann, Nieswandt, Bernhard, Shanks, Emma, Dick, Craig, Murphy, Daniel J.
Publicado 2019

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

por Mpamhanga, Chidochangu P., Spinks, Daniel, Tulloch, Lindsay B., Shanks, Emma J., Robinson, David A., Collie, Iain T., Fairlamb, Alan H., Wyatt, Paul G., Frearson, Julie A., Hunter, William N., Gilbert, Ian H., Brenk, Ruth
Publicado 2009

Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

por Spinks, Daniel, Ong, Han B, Mpamhanga, Chidochangu P, Shanks, Emma J, Robinson, David A, Collie, Iain T, Read, Kevin D, Frearson, Julie A, Wyatt, Paul G, Brenk, Ruth, Fairlamb, Alan H, Gilbert, Ian H
Publicado 2011

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation

por Mardilovich, Katerina, Baugh, Mark, Crighton, Diane, Kowalczyk, Dominika, Gabrielsen, Mads, Munro, June, Croft, Daniel R., Lourenco, Filipe, James, Daniel, Kalna, Gabriella, McGarry, Lynn, Rath, Oliver, Shanks, Emma, Garnett, Mathew J., McDermott, Ultan, Brookfield, Joanna, Charles, Mark, Hammonds, Tim, Olson, Michael F.
Publicado 2015

An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism

por Nacke, Marisa, Sandilands, Emma, Nikolatou, Konstantina, Román-Fernández, Álvaro, Mason, Susan, Patel, Rachana, Lilla, Sergio, Yelland, Tamas, Galbraith, Laura C. A., Freckmann, Eva C., McGarry, Lynn, Morton, Jennifer P., Shanks, Emma, Leung, Hing Y., Markert, Elke, Ismail, Shehab, Zanivan, Sara, Blyth, Karen, Bryant, David M.
Publicado 2021

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments

por Peck, Barrie, Schug, Zachary T., Zhang, Qifeng, Dankworth, Beatrice, Jones, Dylan T., Smethurst, Elizabeth, Patel, Rachana, Mason, Susan, Jiang, Ming, Saunders, Rebecca, Howell, Michael, Mitter, Richard, Spencer-Dene, Bradley, Stamp, Gordon, McGarry, Lynn, James, Daniel, Shanks, Emma, Aboagye, Eric O., Critchlow, Susan E., Leung, Hing Y., Harris, Adrian L., Wakelam, Michael J. O., Gottlieb, Eyal, Schulze, Almut
Publicado 2016

Harnessing synthetic lethality to predict the response to cancer treatment

por Lee, Joo Sang, Das, Avinash, Jerby-Arnon, Livnat, Arafeh, Rand, Auslander, Noam, Davidson, Matthew, McGarry, Lynn, James, Daniel, Amzallag, Arnaud, Park, Seung Gu, Cheng, Kuoyuan, Robinson, Welles, Atias, Dikla, Stossel, Chani, Buzhor, Ella, Stein, Gidi, Waterfall, Joshua J., Meltzer, Paul S., Golan, Talia, Hannenhalli, Sridhar, Gottlieb, Eyal, Benes, Cyril H., Samuels, Yardena, Shanks, Emma, Ruppin, Eytan
Publicado 2018

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

por Miller, Bryan W, Morton, Jennifer P, Pinese, Mark, Saturno, Grazia, Jamieson, Nigel B, McGhee, Ewan, Timpson, Paul, Leach, Joshua, McGarry, Lynn, Shanks, Emma, Bailey, Peter, Chang, David, Oien, Karin, Karim, Saadia, Au, Amy, Steele, Colin, Carter, Christopher Ross, McKay, Colin, Anderson, Kurt, Evans, Thomas R Jeffry, Marais, Richard, Springer, Caroline, Biankin, Andrew, Erler, Janine T, Sansom, Owen J
Publicado 2015

Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition

por Mitchell, Rebecca, Hopcroft, Lisa E M, Baquero, Pablo, Allan, Elaine K, Hewit, Kay, James, Daniel, Hamilton, Graham, Mukhopadhyay, Arunima, O’Prey, Jim, Hair, Alan, Melo, Junia V, Chan, Edmond, Ryan, Kevin M, Maguer-Satta, Véronique, Druker, Brian J, Clark, Richard E, Mitra, Subir, Herzyk, Pawel, Nicolini, Franck E, Salomoni, Paolo, Shanks, Emma, Calabretta, Bruno, Holyoake, Tessa L, Helgason, G Vignir
Publicado 2017

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

por Schug, Zachary T., Peck, Barrie, Jones, Dylan T., Zhang, Qifeng, Grosskurth, Shaun, Alam, Israt S., Goodwin, Louise M., Smethurst, Elizabeth, Mason, Susan, Blyth, Karen, McGarry, Lynn, James, Daniel, Shanks, Emma, Kalna, Gabriela, Saunders, Rebecca E., Jiang, Ming, Howell, Michael, Lassailly, Francois, Thin, May Zaw, Spencer-Dene, Bradley, Stamp, Gordon, van den Broek, Niels J.F., Mackay, Gillian, Bulusu, Vinay, Kamphorst, Jurre J., Tardito, Saverio, Strachan, David, Harris, Adrian L., Aboagye, Eric O., Critchlow, Susan E., Wakelam, Michael J.O., Schulze, Almut, Gottlieb, Eyal
Publicado 2015

HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

por Brunton, Holly, Caligiuri, Giuseppina, Cunningham, Richard, Upstill-Goddard, Rosie, Bailey, Ulla-Maja, Garner, Ian M., Nourse, Craig, Dreyer, Stephan, Jones, Marc, Moran-Jones, Kim, Wright, Derek W., Paulus-Hock, Viola, Nixon, Colin, Thomson, Gemma, Jamieson, Nigel B., McGregor, Grant A., Evers, Lisa, McKay, Colin J., Gulati, Aditi, Brough, Rachel, Bajrami, Ilirjana, Pettitt, Stephen J., Dziubinski, Michele L., Barry, Simon T., Grützmann, Robert, Brown, Robert, Curry, Edward, Pajic, Marina, Musgrove, Elizabeth A., Petersen, Gloria M., Shanks, Emma, Ashworth, Alan, Crawford, Howard C., Simeone, Diane M., Froeling, Fieke E.M., Lord, Christopher J., Mukhopadhyay, Debabrata, Pilarsky, Christian, Grimmond, Sean E., Morton, Jennifer P., Sansom, Owen J., Chang, David K., Bailey, Peter J., Biankin, Andrew V.
Publicado 2020