Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

por Shanks, Emma J., Ong, Han B., Robinson, David A., Thompson, Stephen, Sienkiewicz, Natasha, Fairlamb, Alan H., Frearson, Julie A.
Publicado 2010

Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

por Patterson, Stephen, Jones, Deuan C, Shanks, Emma J, Frearson, Julie A, Gilbert, Ian H, Wyatt, Paul G, Fairlamb, Alan H
Publicado 2009

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallo...

por Patterson, Stephen, Alphey, Magnus S., Jones, Deuan C., Shanks, Emma J., Street, Ian P., Frearson, Julie A., Wyatt, Paul G., Gilbert, Ian H., Fairlamb, Alan H.
Publicado 2011

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines

por Gardner, Nicola J., Gillespie, Peter J., Carrington, Jamie T., Shanks, Emma J., McElroy, Stuart P., Haagensen, Emma J., Frearson, Julie A., Woodland, Andrew, Blow, J. Julian
Publicado 2017

Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

por Spinks, Daniel, Shanks, Emma J, Cleghorn, Laura A T, McElroy, Stuart, Jones, Deuan, James, Daniel, Fairlamb, Alan H, Frearson, Julie A, Wyatt, Paul G, Gilbert, Ian H
Publicado 2009

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

por Mpamhanga, Chidochangu P., Spinks, Daniel, Tulloch, Lindsay B., Shanks, Emma J., Robinson, David A., Collie, Iain T., Fairlamb, Alan H., Wyatt, Paul G., Frearson, Julie A., Hunter, William N., Gilbert, Ian H., Brenk, Ruth
Publicado 2009

Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

por Spinks, Daniel, Ong, Han B, Mpamhanga, Chidochangu P, Shanks, Emma J, Robinson, David A, Collie, Iain T, Read, Kevin D, Frearson, Julie A, Wyatt, Paul G, Brenk, Ruth, Fairlamb, Alan H, Gilbert, Ian H
Publicado 2011