Whole-Genome DNA Methylation Profiling of CD14+ Monocytes Reveals Disease Status and Activity Differences in Crohn’s Disease Patients

por Li Yim, Andrew Y.F., Duijvis, Nicolette W., Ghiboub, Mohammed, Sharp, Catriona, Ferrero, Enrico, Mannens, Marcel M.A.M., D’Haens, Geert R., de Jonge, Wouter J., te Velde, Anje A., Henneman, Peter
Publicado 2020

Pharmacological validation of targets regulating CD14 during macrophage differentiation

por Jimenez-Duran, Gisela, Luque-Martin, Rosario, Patel, Meghana, Koppe, Emma, Bernard, Sharon, Sharp, Catriona, Buchan, Natalie, Rea, Ceara, de Winther, Menno P.J., Turan, Nil, Angell, Davina, Wells, Christine A., Cousins, Rick, Mander, Palwinder K., Masters, Seth L.
Publicado 2020

A distinct epigenetic profile distinguishes stenotic from non-inflamed fibroblasts in the ileal mucosa of Crohn’s disease patients

por Li Yim, Andrew Y. F., de Bruyn, Jessica R., Duijvis, Nicolette W., Sharp, Catriona, Ferrero, Enrico, de Jonge, Wouter J., Wildenberg, Manon E., Mannens, Marcel M. A. M., Buskens, Christianne J., D’Haens, Geert R., Henneman, Peter, te Velde, Anje A.
Publicado 2018

Phase 1 and preclinical profiling of ESM‐HDAC391, a myeloid‐targeted histone deacetylase inhibitor, shows enhanced pharmacology and monocytopaenia

por Furze, Rebecca C., Molnar, Judit, Parr, Nigel J., Ahmad, Faiz, Henry, Yvette, Howe, David, Singh, Rajendra, Toal, Martin, Bassil, Anna K., Bernard, Sharon G., Davis, Robert P., Gibson, Adele, Maller, N. Claire, Sharp, Catriona, Tough, David F., Prinjha, Rab K., Lewis, Huw D.
Publicado 2022