The Crystal Structure of Engineered Nitroreductase NTR 2.0 and Impact of F70A and F108Y Substitutions on Substrate Specificity

por Sharrock, Abigail V., Mumm, Jeff S., Bagdžiūnas, Gintautas, Čėnas, Narimantas, Arcus, Vickery L., Ackerley, David F.
Publicado 2023

Metathramycin, a new bioactive aureolic acid discovered by heterologous expression of a metagenome derived biosynthetic pathway

por Stevenson, Luke J., Bracegirdle, Joe, Liu, Liwei, Sharrock, Abigail V., Ackerley, David F., Keyzers, Robert A., Owen, Jeremy G.
Publicado 2021

Engineering the Escherichia coli Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System

por Sharrock, Abigail V., McManaway, Sarah P., Rich, Michelle H., Mumm, Jeff S., Hermans, Ian F., Tercel, Moana, Pruijn, Frederik B., Ackerley, David F.
Publicado 2021

An inducible model of chronic hyperglycemia

por Tucker, Tori R., Knitter, Courtney A., Khoury, Deena M., Eshghi, Sheida, Tran, Sophia, Sharrock, Abigail V., Wiles, Travis J., Ackerley, David F., Mumm, Jeff S., Parsons, Michael J.
Publicado 2023

A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening

por Rich, Michelle H, Sharrock, Abigail V, Mulligan, Timothy S, Matthews, Frazer, Brown, Alistair S, Lee-Harwood, Hannah R, Williams, Elsie M, Copp, Janine N, Little, Rory F, Francis, Jenni JB, Horvat, Claire N, Stevenson, Luke J, Owen, Jeremy G, Saxena, Meera T, Mumm, Jeff S, Ackerley, David F
Publicado 2023

NTR 2.0: a rationally-engineered prodrug converting enzyme with substantially enhanced efficacy for targeted cell ablation

por Sharrock, Abigail V., Mulligan, Timothy S., Hall, Kelsi R., Williams, Elsie M., White, David T., Zhang, Liyun, Emmerich, Kevin, Matthews, Frazer, Nimmagadda, Saumya, Washington, Selena, Le, Katherine D., Meir-Levi, Danielle, Cox, Olivia L., Saxena, Meera T., Calof, Anne L., Lopez-Burks, Martha E., Lander, Arthur D., Ding, Ding, Ji, Hongkai, Ackerley, David F., Mumm, Jeff S.
Publicado 2022

Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa

por Zhang, Liyun, Chen, Conan, Fu, Jie, Lilley, Brendan, Berlinicke, Cynthia, Hansen, Baranda, Ding, Ding, Wang, Guohua, Wang, Tao, Shou, Daniel, Ye, Ying, Mulligan, Timothy, Emmerich, Kevin, Saxena, Meera T, Hall, Kelsi R, Sharrock, Abigail V, Brandon, Carlene, Park, Hyejin, Kam, Tae-In, Dawson, Valina L, Dawson, Ted M, Shim, Joong Sup, Hanes, Justin, Ji, Hongkai, Liu, Jun O, Qian, Jiang, Ackerley, David F, Rohrer, Baerbel, Zack, Donald J, Mumm, Jeff S
Publicado 2021