Efficacy of Oral APX001 in a Murine Model of Cryptococcal Meningitis

por Schell, Wiley A, Giamberardino, Charles, Shaw, Karen J, Perfect, John R
Publicado 2017

Absorption, Distribution, and Excretion of (14)C-APX001 after Single-Dose Administration to Rats and Monkeys

por Mansbach, Robert, Shaw, Karen J, Hodges, Michael R, Coleman, Samantha, Fitzsimmons, Michael E
Publicado 2017

Calcineurin Inhibitors Synergize with Manogepix to Kill Diverse Human Fungal Pathogens

por Liston, Sean D., Whitesell, Luke, Kapoor, Mili, Shaw, Karen J., Cowen, Leah E.
Publicado 2022

Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition

por Orelle, Cédric, Szal, Teresa, Klepacki, Dorota, Shaw, Karen J., Vázquez-Laslop, Nora, Mankin, Alexander S.
Publicado 2013

678. Galactomannan Is a Biomarker of APX001 (Fosmanogepix) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis

por Gebremariam, Teklegiorgis, Alkhazraji, Sondus, Gu, Yiyou, Alqarihi, Abdullah, Mamouei, Zeinab, Shaw, Karen J, Ibrahim, Ashraf S
Publicado 2019

726. APX001 (Fosmanogepix) Is Effective in an Immunosuppressed Mouse Model of Rhizopus oryzae Infection

por Gebremariam, Teklegiorgis, Alkhazraji, Sondus, Gu, Yiyou, Alqarihi, Abdullah, Mamouei, Zeinab, Shaw, Karen J, Ibrahim, Ashraf S
Publicado 2019

1275. Evaluation of in vitro activity of manogepix against multidrug-resistant and pan-resistant Candida auris from the New York Outbreak

por Zhu, Yan Chun, Kilburn, Shannon N, Kapoor, Mili, Chaturvedi, Sudha, Shaw, Karen J, Chaturvedi, Vishnu
Publicado 2020

In Vitro and In Vivo Evaluation of the Antifungal Activity of APX001A/APX001 against Candida auris

por Hager, Christopher L., Larkin, Emily L., Long, Lisa, Zohra Abidi, Fatima, Shaw, Karen J., Ghannoum, Mahmoud A.
Publicado 2018

APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis

por Gebremariam, Teclegiorgis, Alkhazraji, Sondus, Alqarihi, Abdullah, Jeon, Heewon H., Gu, Yiyou, Kapoor, Mili, Shaw, Karen J., Ibrahim, Ashraf S.
Publicado 2019

Efficacy of Delayed Therapy with Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis

por Wiederhold, Nathan P., Najvar, Laura K., Shaw, Karen J., Jaramillo, Rosie, Patterson, Hoja, Olivo, Marcos, Catano, Gabriel, Patterson, Thomas F.
Publicado 2019

Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis

por Alkhazraji, Sondus, Gebremariam, Teclegiorgis, Alqarihi, Abdullah, Gu, Yiyou, Mamouei, Zeinab, Singh, Shakti, Wiederhold, Nathan P., Shaw, Karen J., Ibrahim, Ashraf S.
Publicado 2020

1954. In vivo Efficacy of Delayed Therapy with the Novel Inositol Acyltransferase Inhibitor Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis

por Wiederhold, Nathan P, Najvar, Laura K, Shaw, Karen J, Jaramillo, Rosie, Patterson, Hoja P, Olivo, Marcos, Catano, Gabriel, Patterson, Thomas F
Publicado 2019

1282. Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In vitro Activity Against Members of the Fusarium oxysporum and Fusarium solani Species C...

por Badali, Hamid, Patterson, Hoja, Sanders, Carmita, Mermella, Barbara, Gibas, Connie, Mele, James, Fan, Hongxin, Ibrahim, Ashraf S, Shaw, Karen J, Wiederhold, Nathan P
Publicado 2020

Safety and Pharmacokinetics of Intravenous and Oral Fosmanogepix, a First-in-Class Antifungal Agent, in Healthy Volunteers

por Hodges, Michael R., Ople, Eric, Wedel, Pamela, Shaw, Karen J., Jakate, Abhijeet, Kramer, William G., van Marle, Sjoerd, van Hoogdalem, Ewoud-Jan, Tawadrous, Margaret
Publicado 2023

168. Efficacy of the Novel gwt1 Inhibitor APX2039 in a Rabbit Model of cryptococcus Meningitis

por Shaw, Karen J, Giamberardino, Charles D, Soltow, Quinlyn A, Tenor, Jennifer, Toffaletti, Dena, Boua, Jane-Valeriane, Marius, Choiselle, Palmucci, Julia R, Perfect, John R
Publicado 2020

Tricyclic GyrB/ParE (TriBE) Inhibitors: A New Class of Broad-Spectrum Dual-Targeting Antibacterial Agents

por Tari, Leslie W., Li, Xiaoming, Trzoss, Michael, Bensen, Daniel C., Chen, Zhiyong, Lam, Thanh, Zhang, Junhu, Lee, Suk Joong, Hough, Grayson, Phillipson, Doug, Akers-Rodriguez, Suzanne, Cunningham, Mark L., Kwan, Bryan P., Nelson, Kirk J., Castellano, Amanda, Locke, Jeff B., Brown-Driver, Vickie, Murphy, Timothy M., Ong, Voon S., Pillar, Chris M., Shinabarger, Dean L., Nix, Jay, Lightstone, Felice C., Wong, Sergio E., Nguyen, Toan B., Shaw, Karen J., Finn, John
Publicado 2013