Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice

por Shaw, Reuben J., Cantley, Lewis C.
Publicado 2012

Raptor is Phosphorylated by cdc2 during Mitosis

por Gwinn, Dana M., Asara, John M., Shaw, Reuben J.
Publicado 2010

Optimizing Dietary Restriction for Genetic Epistasis Analysis and Gene Discovery in C. elegans

por Mair, William, Panowski, Siler H., Shaw, Reuben J., Dillin, Andrew
Publicado 2009

Mechanisms and consequences of hepatic regulation of mTORC1 by metformin

por Howell, Jessica J, Hellberg, Kristina, Shaw, Reuben J, Manning, Brendan D
Publicado 2014

Reduced cell proliferation by IKK2 depletion in a mouse lung cancer model

por Xia, Yifeng, Yeddula, Narayana, Leblanc, Mathias, Ke, Eugene, Zhang, Yonghui, Oldfield, Eric, Shaw, Reuben J., Verma, Inder M.
Publicado 2012

AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes

por Young, Nathan P., Kamireddy, Anwesh, Van Nostrand, Jeanine L., Eichner, Lillian J., Shokhirev, Maxim Nikolaievich, Dayn, Yelena, Shaw, Reuben J.
Publicado 2016

Progressive alterations in amino acid and lipid metabolism correlate with peripheral neuropathy in Polg(D257A) mice

por Lim, Esther W., Handzlik, Michal K., Trefts, Elijah, Gengatharan, Jivani M., Pondevida, Carlos M., Shaw, Reuben J., Metallo, Christian M.
Publicado 2021

The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non–small cell lung cancer

por Rodón, Laura, Svensson, Robert U., Wiater, Ezra, Chun, Matthew G. H, Tsai, Wen-Wei, Eichner, Lillian J., Shaw, Reuben J., Montminy, Marc
Publicado 2019

Pulsed Azidohomoalanine Labeling in Mammals (PALM) Detects Changes in Liver-Specific LKB1 Knockout Mice

por McClatchy, Daniel B., Ma, Yuanhui, Liu, Chao, Stein, Benjamin D., Martínez-Bartolomé, Salvador, Vasquez, Debbie, Hellberg, Kristina, Shaw, Reuben J., Yates, John R.
Publicado 2015

Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter

por Schmitt, Danielle L., Curtis, Stephanie D., Lyons, Anne C., Zhang, Jin-fan, Chen, Mingyuan, He, Catherine Y., Mehta, Sohum, Shaw, Reuben J., Zhang, Jin
Publicado 2022

HDAC3 is critical in tumor development and therapeutic resistance in Kras-mutant non–small cell lung cancer

por Eichner, Lillian J., Curtis, Stephanie D., Brun, Sonja N., McGuire, Caroline K., Gushterova, Irena, Baumgart, Joshua T., Trefts, Elijah, Ross, Debbie S., Rymoff, Tammy J., Shaw, Reuben J.
Publicado 2023

Inter-organelle cross-talk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress

por Kuna, Ramya S., Kumar, Avi, Wessendorf-Rodriguez, Karl A., Galvez, Hector, Green, Courtney R., McGregor, Grace H., Cordes, Thekla, Shaw, Reuben J., Svensson, Robert U., Metallo, Christian M.
Publicado 2023

AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation

por Van Nostrand, Jeanine L., Hellberg, Kristina, Luo, En-Ching, Van Nostrand, Eric L., Dayn, Alina, Yu, Jingting, Shokhirev, Maxim N., Dayn, Yelena, Yeo, Gene W., Shaw, Reuben J.
Publicado 2020

AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy

por Hung, Chien-Min, Lombardo, Portia S., Malik, Nazma, Brun, Sonja N., Hellberg, Kristina, Van Nostrand, Jeanine L., Garcia, Daniel, Baumgart, Joshua, Diffenderfer, Ken, Asara, John M., Shaw, Reuben J.
Publicado 2021

Circadian disruption enhances HSF1 signaling and tumorigenesis in Kras-driven lung cancer

por Pariollaud, Marie, Ibrahim, Lara H., Irizarry, Emanuel, Mello, Rebecca M., Chan, Alanna B., Altman, Brian J., Shaw, Reuben J., Bollong, Michael J., Wiseman, R. Luke, Lamia, Katja A.
Publicado 2022

Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling

por Lin, Chenchu, Blessing, Alicia M., Pulliam, Thomas L., Shi, Yan, Wilkenfeld, Sandi R., Han, Jenny J., Murray, Mollianne M., Pham, Alexander H., Duong, Kevin, Brun, Sonja N., Shaw, Reuben J., Ittmann, Michael M., Frigo, Daniel E.
Publicado 2021

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD

por Garcia, Daniel, Hellberg, Kristina, Chaix, Amandine, Wallace, Martina, Herzig, Sébastien, Badur, Mehmet G., Lin, Terry, Shokhirev, Maxim N., Pinto, Antonio F.M., Ross, Debbie S., Saghatelian, Alan, Panda, Satchidananda, Dow, Lukas E., Metallo, Christian M., Shaw, Reuben J.
Publicado 2019

LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma

por Stein, Benjamin D., Ferrarone, John R., Gardner, Eric E., Chang, Jae Won, Wu, David, Hollstein, Pablo E., Liang, Roger J., Yuan, Min, Chen, Qiuying, Coukos, John S., Sindelar, Miriam, Ngo, Bryan, Gross, Steven S., Shaw, Reuben J., Zhang, Chen, Asara, John M., Moellering, Raymond E., Varmus, Harold, Cantley, Lewis C.
Publicado 2023

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small cell lung cancer in preclinical models

por Svensson, Robert U., Parker, Seth J., Eichner, Lillian J., Kolar, Matthew J., Wallace, Martina, Brun, Sonja N., Lombardo, Portia S., Van Nostrand, Jeanine L., Hutchins, Amanda, Vera, Lilliana, Gerken, Laurie, Greenwood, Jeremy, Bhat, Sathesh, Harriman, Geraldine, Westlin, William F., Harwood, H. James, Saghatelian, Alan, Kapeller, Rosana, Metallo, Christian M., Shaw, Reuben J.
Publicado 2016

Mutations in foregut SOX2(+) cells induce efficient proliferation via CXCR2 pathway

por Hishida, Tomoaki, Vazquez-Ferrer, Eric, Hishida-Nozaki, Yuriko, Sancho-Martinez, Ignacio, Takahashi, Yuta, Hatanaka, Fumiyuki, Wu, Jun, Ocampo, Alejandro, Reddy, Pradeep, Wu, Min-Zu, Gerken, Laurie, Shaw, Reuben J., Rodriguez Esteban, Concepcion, Benner, Christopher, Nakagawa, Hiroshi, Guillen Garcia, Pedro, Nuñez Delicado, Estrella, Castells, Antoni, Campistol, Josep M., Liu, Guang-Hui, Izpisua Belmonte, Juan Carlos
Publicado 2019