DNA polymerase δ proofreads errors made by DNA polymerase ε

por Bulock, Chelsea R., Xing, Xuanxuan, Shcherbakova, Polina V.
Publicado 2020

Mismatch repair and DNA polymerase δ proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ϵ variant

por Bulock, Chelsea R, Xing, Xuanxuan, Shcherbakova, Polina V
Publicado 2020

DNA Polymerase ζ-Dependent Lesion Bypass in Saccharomyces cerevisiae Is Accompanied by Error-Prone Copying of Long Stretches of Adjacent DNA

por Kochenova, Olga V., Daee, Danielle L., Mertz, Tony M., Shcherbakova, Polina V.
Publicado 2015

Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae

por Barbari, Stephanie R., Kane, Daniel P., Moore, Elizabeth A., Shcherbakova, Polina V.
Publicado 2018

Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase δ mutation in human cells

por Mertz, Tony M., Baranovskiy, Andrey G., Wang, Jing, Tahirov, Tahir H., Shcherbakova, Polina V.
Publicado 2017

Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors

por Lee, Minyi, Eng, George, Barbari, Stephanie R., Deshpande, Vikram, Shcherbakova, Polina V., Gala, Manish K.
Publicado 2020

Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε

por Parkash, Vimal, Kulkarni, Yashraj, ter Beek, Josy, Shcherbakova, Polina V., Kamerlin, Shina Caroline Lynn, Johansson, Erik
Publicado 2019

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

por Xing, Xuanxuan, Kane, Daniel P., Bulock, Chelsea R., Moore, Elizabeth A., Sharma, Sushma, Chabes, Andrei, Shcherbakova, Polina V.
Publicado 2019

Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ϵ variants at low dNTP levels

por Barbari, Stephanie R, Beach, Annette K, Markgren, Joel G, Parkash, Vimal, Moore, Elizabeth A, Johansson, Erik, Shcherbakova, Polina V
Publicado 2022

Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations

por Kochenova, Olga V., Bezalel-Buch, Rachel, Tran, Phong, Makarova, Alena V., Chabes, Andrei, Burgers, Peter M. J., Shcherbakova, Polina V.
Publicado 2017

A Reversible Histone H3 Acetylation Cooperates with Mismatch Repair and Replicative Polymerases in Maintaining Genome Stability

por Kadyrova, Lyudmila Y., Mertz, Tony M., Zhang, Yu, Northam, Matthew R., Sheng, Ziwei, Lobachev, Kirill S., Shcherbakova, Polina V., Kadyrov, Farid A.
Publicado 2013

DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures

por Northam, Matthew R., Moore, Elizabeth A., Mertz, Tony M., Binz, Sara K., Stith, Carrie M., Stepchenkova, Elena I., Wendt, Kathern L., Burgers, Peter M. J., Shcherbakova, Polina V.
Publicado 2014