K27‐linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation

por Shearer, Robert F, Typas, Dimitris, Coscia, Fabian, Schovsbo, Sofie, Kruse, Thomas, Mund, Andreas, Mailand, Niels
Publicado 2022

A Novel SERPINA1 Mutation Causing Serum Alpha(1)-Antitrypsin Deficiency

por Saunders, Darren N., Tindall, Elizabeth A., Shearer, Robert F., Roberson, Jacquelyn, Decker, Amy, Wilson, Jean Amos, Hayes, Vanessa M.
Publicado 2012

Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate‐induced apoptosis

por Balaban, Seher, Lee, Lisa S., Varney, Bianca, Aishah, Atqiya, Gao, Quanqing, Shearer, Robert F., Saunders, Darren N., Grewal, Thomas, Hoy, Andrew J.
Publicado 2018

The E3 ubiquitin ligase UBR5 regulates centriolar satellite stability and primary cilia

por Shearer, Robert F., Frikstad, Kari-Anne Myrum, McKenna, Jessie, McCloy, Rachael A., Deng, Niantao, Burgess, Andrew, Stokke, Trond, Patzke, Sebastian, Saunders, Darren N.
Publicado 2018

SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation

por Lee, Jodi A., Yerbury, Justin J., Farrawell, Natalie, Shearer, Robert F., Constantinescu, Patrick, Hatters, Danny M., Schroder, Wayne A., Suhrbier, Andreas, Wilson, Mark R., Saunders, Darren N., Ranson, Marie
Publicado 2015

Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration

por Balaban, Seher, Shearer, Robert F., Lee, Lisa S., van Geldermalsen, Michelle, Schreuder, Mark, Shtein, Harrison C., Cairns, Rose, Thomas, Kristen C., Fazakerley, Daniel J., Grewal, Thomas, Holst, Jeff, Saunders, Darren N., Hoy, Andrew J.
Publicado 2017

Mitochondrial mutations and metabolic adaptation in pancreatic cancer

por Hardie, Rae-Anne, van Dam, Ellen, Cowley, Mark, Han, Ting-Li, Balaban, Seher, Pajic, Marina, Pinese, Mark, Iconomou, Mary, Shearer, Robert F., McKenna, Jessie, Miller, David, Waddell, Nicola, Pearson, John V., Grimmond, Sean M., Sazanov, Leonid, Biankin, Andrew V., Villas-Boas, Silas, Hoy, Andrew J., Turner, Nigel, Saunders, Darren N.
Publicado 2017

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer

por Kennedy, Sean P., Han, Jeremy Z. R., Portman, Neil, Nobis, Max, Hastings, Jordan F., Murphy, Kendelle J., Latham, Sharissa L., Cadell, Antonia L., Miladinovic, Dushan, Marriott, Gabriella R., O’Donnell, Yolande E. I., Shearer, Robert F., Williams, James T., Munoz, Amaya Garcia, Cox, Thomas R., Watkins, D. Neil, Saunders, Darren N., Timpson, Paul, Lim, Elgene, Kolch, Walter, Croucher, David R.
Publicado 2019

Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer

por Conway, James R.W., Warren, Sean C., Herrmann, David, Murphy, Kendelle J., Cazet, Aurélie S., Vennin, Claire, Shearer, Robert F., Killen, Monica J., Magenau, Astrid, Mélénec, Pauline, Pinese, Mark, Nobis, Max, Zaratzian, Anaiis, Boulghourjian, Alice, Da Silva, Andrew M., del Monte-Nieto, Gonzalo, Adam, Arne S.A., Harvey, Richard P., Haigh, Jody J., Wang, Yingxiao, Croucher, David R., Sansom, Owen J., Pajic, Marina, Caldon, C. Elizabeth, Morton, Jennifer P., Timpson, Paul
Publicado 2018

Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy

por Grange, Laura J., Reynolds, John J., Ullah, Farid, Isidor, Bertrand, Shearer, Robert F., Latypova, Xenia, Baxley, Ryan M., Oliver, Antony W., Ganesh, Anil, Cooke, Sophie L., Jhujh, Satpal S., McNee, Gavin S., Hollingworth, Robert, Higgs, Martin R., Natsume, Toyoaki, Khan, Tahir, Martos-Moreno, Gabriel Á., Chupp, Sharon, Mathew, Christopher G., Parry, David, Simpson, Michael A., Nahavandi, Nahid, Yüksel, Zafer, Drasdo, Mojgan, Kron, Anja, Vogt, Petra, Jonasson, Annemarie, Seth, Saad Ahmed, Gonzaga-Jauregui, Claudia, Brigatti, Karlla W., Stegmann, Alexander P. A., Kanemaki, Masato, Josifova, Dragana, Uchiyama, Yuri, Oh, Yukiko, Morimoto, Akira, Osaka, Hitoshi, Ammous, Zineb, Argente, Jesús, Matsumoto, Naomichi, Stumpel, Constance T.R.M., Taylor, Alexander M. R., Jackson, Andrew P., Bielinsky, Anja-Katrin, Mailand, Niels, Le Caignec, Cedric, Davis, Erica E., Stewart, Grant S.
Publicado 2022