The Emerging Role of Hepatocellular eNOS in Non-alcoholic Fatty Liver Disease Development

por Cunningham, Rory P., Sheldon, Ryan D., Rector, R. Scott
Publicado 2020

Reprogramming of iron metabolism confers ferroptosis resistance in ECM-detached cells

por He, Jianping, Abikoye, Abigail M., McLaughlin, Brett P., Middleton, Ryan S., Sheldon, Ryan, Jones, Russell G., Schafer, Zachary T.
Publicado 2023

New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape

por Schultz, Chad R., Sheldon, Ryan D., Xie, Huirong, Demireva, Elena Y., Uhl, Katie L., Agnew, Dalen W., Geerts, Dirk, Bachmann, André S.
Publicado 2023

Differential regulation of adipose tissue and vascular inflammatory gene expression by chronic systemic inhibition of NOS in lean and obese rats

por Padilla, Jaume, Jenkins, Nathan T., Thorne, Pamela K., Lansford, Kasey A., Fleming, Nicholas J., Bayless, David S., Sheldon, Ryan D., Rector, R. Scott, Laughlin, M. Harold
Publicado 2014

Acod1 Expression in Cancer Cells Promotes Immune Evasion through the Generation of Inhibitory Peptides

por Schofield, James H., Longo, Joseph, Sheldon, Ryan D., Albano, Emma, Hawk, Mark A., Murphy, Sean, Duong, Loan, Rahmy, Sharif, Lu, Xin, Jones, Russell G., Schafer, Zachary T.
Publicado 2023

PGC-1β maintains mitochondrial metabolism and restrains inflammatory gene expression

por Guak, Hannah, Sheldon, Ryan D., Beddows, Ian, Vander Ark, Alexandra, Weiland, Matthew J., Shen, Hui, Jones, Russell G., St-Pierre, Julie, Ma, Eric H., Krawczyk, Connie M.
Publicado 2022

The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

por Rauckhorst, Adam J., Gray, Lawrence R., Sheldon, Ryan D., Fu, Xiaorong, Pewa, Alvin D., Feddersen, Charlotte R., Dupuy, Adam J., Gibson-Corley, Katherine N., Cox, James E., Burgess, Shawn C., Taylor, Eric B.
Publicado 2017

ASCT2 is the primary serine transporter in cancer cells

por Conger, Kelly O., Chidley, Christopher, Ozgurses, Mete Emir, Zhao, Huiping, Kim, Yumi, Semina, Svetlana E., Burns, Philippa, Rawat, Vipin, Sheldon, Ryan, Ben-Sahra, Issam, Frasor, Jonna, Sorger, Peter K., DeNicola, Gina M., Coloff, Jonathan L.
Publicado 2023

Prior metabolite extraction fully preserves RNAseq quality and enables integrative multi-‘omics analysis of the liver metabolic response to viral infection

por Madaj, Zachary B, Dahabieh, Michael S., Kamalumpundi, Vijayvardhan, Muhire, Brejnev, Pettinga, J., Siwicki, Rebecca A., Ellis, Abigail E., Isaguirre, Christine, Escobar Galvis, Martha L., DeCamp, Lisa, Jones, Russell G., Givan, Scott A., Adams, Marie, Sheldon, Ryan D.
Publicado 2023

Mitochondrial citrate metabolism and efflux regulate BeWo differentiation

por Mahr, Renee M., Jena, Snehalata, Nashif, Sereen K., Nelson, Alisa B., Rauckhorst, Adam J., Rome, Ferrol I., Sheldon, Ryan D., Hughey, Curtis C., Puchalska, Patrycja, Gearhart, Micah D., Taylor, Eric B., Crawford, Peter A., Wernimont, Sarah A.
Publicado 2023

A rapid microglial metabolic response controls metabolism and improves memory

por Drougard, Anne, Ma, Eric H, Wegert, Vanessa, Sheldon, Ryan, Panzeri, Ilaria, Vatsa, Naman, Apostle, Stefanos, Fagnocchi, Luca, Schaf, Judith, Gossens, Klaus, Völker, Josephine, Pang, Shengru, Bremser, Anna, Dror, Erez, Giacona, Francesca, Sagar, Henderson, Michael X, Prinz, Marco, Jones, Russell G, Pospisilik, J. Andrew
Publicado 2023

Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis

por Tompkins, Sean C., Sheldon, Ryan D., Rauckhorst, Adam J., Noterman, Maria F., Solst, Shane R., Buchanan, Jane L., Mapuskar, Kranti A., Pewa, Alvin D., Gray, Lawrence R., Oonthonpan, Lalita, Sharma, Arpit, Scerbo, Diego A., Dupuy, Adam J., Spitz, Douglas R., Taylor, Eric B.
Publicado 2019

(13)C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8(+) T cells

por Ma, Eric H., Dahabieh, Michael S., DeCamp, Lisa M., Kaymak, Irem, Kitchen-Goosen, Susan M., Roy, Dominic G., Verway, Mark J., Johnson, Radia M., Samborska, Bozena, Scullion, Catherine A., Steadman, Mya, Vos, Matthew, Roddy, Thomas P., Krawczyk, Connie M., Williams, Kelsey S., Sheldon, Ryan D., Jones, Russell G.
Publicado 2023

Carbon source availability drives nutrient utilization in CD8(+) T cells

por Kaymak, Irem, Luda, Katarzyna M., Duimstra, Lauren R., Ma, Eric H., Longo, Joseph, Dahabieh, Michael S., Faubert, Brandon, Oswald, Brandon M., Watson, McLane J., Kitchen-Goosen, Susan M., DeCamp, Lisa M., Compton, Shelby E., Fu, Zhen, DeBerardinis, Ralph J., Williams, Kelsey S., Sheldon, Ryan D., Jones, Russell G.
Publicado 2022

Repression of LKB1 by miR-17∼92 Sensitizes MYC-Dependent Lymphoma to Biguanide Treatment

por Izreig, Said, Gariepy, Alexandra, Kaymak, Irem, Bridges, Hannah R., Donayo, Ariel O., Bridon, Gaëlle, DeCamp, Lisa M., Kitchen-Goosen, Susan M., Avizonis, Daina, Sheldon, Ryan D., Laister, Rob C., Minden, Mark D., Johnson, Nathalie A., Duchaine, Thomas F., Rudoltz, Marc S., Yoo, Sanghee, Pollak, Michael N., Williams, Kelsey S., Jones, Russell G.
Publicado 2020

1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer

por Kilgour, Marisa K., MacPherson, Sarah, Zacharias, Lauren G., Ellis, Abigail E., Sheldon, Ryan D., Liu, Elaine Y., Keyes, Sarah, Pauly, Brenna, Carleton, Gillian, Allard, Bertrand, Smazynski, Julian, Williams, Kelsey S., Watson, Peter H., Stagg, John, Nelson, Brad H., DeBerardinis, Ralph J., Jones, Russell G., Hamilton, Phineas T., Lum, Julian J.
Publicado 2021

Itaconate confers tolerance to late NLRP3 inflammasome activation

por Bambouskova, Monika, Potuckova, Lucie, Paulenda, Tomas, Kerndl, Martina, Mogilenko, Denis A., Lizotte, Kate, Swain, Amanda, Hayes, Sebastian, Sheldon, Ryan D., Kim, Hyeryun, Kapadnis, Unnati, Ellis, Abigail E., Isaguirre, Christine, Burdess, Samantha, Laha, Anwesha, Amarasinghe, Gaya K., Chubukov, Victor, Roddy, Thomas P., Diamond, Michael S., Jones, Russell G., Simons, Donald M., Artyomov, Maxim N.
Publicado 2021

Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness

por Sharma, Arpit, Oonthonpan, Lalita, Sheldon, Ryan D, Rauckhorst, Adam J, Zhu, Zhiyong, Tompkins, Sean C, Cho, Kevin, Grzesik, Wojciech J, Gray, Lawrence R, Scerbo, Diego A, Pewa, Alvin D, Cushing, Emily M, Dyle, Michael C, Cox, James E, Adams, Chris, Davies, Brandon S, Shields, Richard K, Norris, Andrew W, Patti, Gary, Zingman, Leonid V, Taylor, Eric B
Publicado 2019

Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes

por Gunasekar, Susheel K., Xie, Litao, Kumar, Ashutosh, Hong, Juan, Chheda, Pratik R., Kang, Chen, Kern, David M., My-Ta, Chau, Maurer, Joshua, Heebink, John, Gerber, Eva E., Grzesik, Wojciech J., Elliot-Hudson, Macaulay, Zhang, Yanhui, Key, Phillip, Kulkarni, Chaitanya A., Beals, Joseph W., Smith, Gordon I., Samuel, Isaac, Smith, Jessica K., Nau, Peter, Imai, Yumi, Sheldon, Ryan D., Taylor, Eric B., Lerner, Daniel J., Norris, Andrew W., Klein, Samuel, Brohawn, Stephen G., Kerns, Robert, Sah, Rajan
Publicado 2022