RNA Modifications and RNA Metabolism in Neurological Disease Pathogenesis

por Chatterjee, Biswanath, Shen, Che-Kun James, Majumder, Pritha
Publicado 2021

G-CSF rescues the memory impairment of animal models of Alzheimer's disease

por Tsai, Kuen-Jer, Tsai, Yueh-Chiao, Shen, Che-Kun James
Publicado 2007

Similar dose-dependence of motor neuron cell death caused by wild type human TDP-43 and mutants with ALS-associated amino acid substitutions

por Wu, Lien-Szu, Cheng, Wei-Cheng, Shen, Che-Kun James
Publicado 2013

Phosphorylation-Dependent SUMOylation of the Transcription Factor NF-E2

por Su, Yee-Fun, Shyu, Yu-Chiau, Shen, Che-Kun James, Hwang, Jaulang
Publicado 2012

Epigenetic Enhancement of the Post-replicative DNA Mismatch Repair of Mammalian Genomes by a Hemi-(m)CpG-Np95-Dnmt1 Axis

por Wang, Keh-Yang, Chen, Chun-Chang, Tsai, Shih-Feng, Shen, Che-Kun James
Publicado 2016

Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRP

por Majumder, Pritha, Chu, Jen-Fei, Chatterjee, Biswanath, Swamy, Krishna B. S., Shen, Che-Kun James
Publicado 2016

Structural insights into TDP-43 in nucleic-acid binding and domain interactions

por Kuo, Pan-Hsien, Doudeva, Lyudmila G., Wang, Yi-Ting, Shen, Che-Kun James, Yuan, Hanna S.
Publicado 2009

Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation

por Chiang, Chien-Hao, Grauffel, Cédric, Wu, Lien-Szu, Kuo, Pan-Hsien, Doudeva, Lyudmila G., Lim, Carmay, Shen, Che-Kun James, Yuan, Hanna S.
Publicado 2016

Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS

por Chang, Cheng-Fu, Lee, Yi-Chao, Lee, Kuen-Haur, Lin, Hui-Ching, Chen, Chia-Ling, Shen, Che-Kun James, Huang, Chi-Chen
Publicado 2016

Human Mesenchymal Stem Cells Prolong Survival and Ameliorate Motor Deficit through Trophic Support in Huntington's Disease Mouse Models

por Lin, Yuan-Ta, Chern, Yijuang, Shen, Che-Kun James, Wen, Hsin-Lan, Chang, Ya-Chin, Li, Hung, Cheng, Tzu-Hao, Hsieh-Li, Hsiu Mei
Publicado 2011

A robust TDP-43 knock-in mouse model of ALS

por Huang, Shih-Ling, Wu, Lien-Szu, Lee, Min, Chang, Chin-Wen, Cheng, Wei-Cheng, Fang, Yu-Sheng, Chen, Yun-Ru, Cheng, Pei-Lin, Shen, Che-Kun James
Publicado 2020

A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis

por Hung, Chun-Hao, Lee, Tung-Liang, Huang, Anna Yu-Szu, Yang, Kang-Chung, Shyu, Yu-Chiau, Wen, Shau-Ching, Lu, Mu-Jie, Yuan, Shinsheng, Shen, Che-Kun James
Publicado 2021

Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U

por Tsai, Kuen-Jer, Yang, Chun-Hung, Fang, Yen-Hsin, Cho, Kuan-Hung, Chien, Wei-Lin, Wang, Wei-Ting, Wu, Tzu-Wei, Lin, Ching-Po, Fu, Wen-Mei, Shen, Che-Kun James
Publicado 2010

Targeted Disruption in Mice of a Neural Stem Cell-Maintaining, KRAB-Zn Finger-Encoding Gene That Has Rapidly Evolved in the Human Lineage

por Chien, Huan-Chieh, Wang, Hurng-Yi, Su, Yi-Ning, Lai, Kuan-Yu, Lu, Li-Chen, Chen, Pau-Chung, Tsai, Shih-Feng, Wu, Chung-I, Hsieh, Wu-Shiun, Shen, Che-Kun James
Publicado 2012

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology

por Lee, Yi-Chao, Huang, Wan-Chen, Lin, Jiann-Her, Kao, Tzu-Jen, Lin, Hui-Ching, Lee, Kuen-Haur, Lin, Hsin-Chuan, Shen, Che-Kun James, Chang, Wen-Chang, Huang, Chi-Chen
Publicado 2018

Negative Regulation of the Differentiation of Flk2(−) CD34(−) LSK Hematopoietic Stem Cells by EKLF/KLF1

por Hung, Chun-Hao, Wang, Keh-Yang, Liou, Yae-Huei, Wang, Jing-Ping, Huang, Anna Yu-Szu, Lee, Tung-Liang, Jiang, Si-Tse, Liao, Nah-Shih, Shyu, Yu-Chiau, Shen, Che-Kun James
Publicado 2020

TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh

por Zhao, Limin, Ke, Hao, Xu, Haibo, Wang, Guo-Dong, Zhang, Honglei, Zou, Li, Xiang, Shu, Li, Mengyuan, Peng, Li, Zhou, Mingfang, Li, Lingling, Ao, Lei, Yang, Qin, Shen, Che-Kun James, Yi, Ping, Wang, Lu, Jiao, Baowei
Publicado 2020

Genetic Disruption of KLF1 K74 SUMOylation in Hematopoietic System Promotes Healthy Longevity in Mice

por Shyu, Yu‐Chiau, Liao, Po‐Cheng, Huang, Ting‐Shou, Yang, Chun‐Ju, Lu, Mu‐Jie, Huang, Shih‐Ming, Lin, Xin‐Yu, Liou, Cai‐Cin, Kao, Yu‐Hsiang, Lu, Chi‐Huan, Peng, Hui‐Ling, Chen, Jim‐Ray, Cherng, Wen‐Jin, Yang, Ning‐I, Chen, Yung‐Chang, Pan, Heng‐Chih, Jiang, Si‐Tse, Hsu, Chih‐Chin, Lin, Gigin, Yuan, Shin‐Sheng, Hsu, Paul Wei‐Che, Wu, Kou‐Juey, Lee, Tung‐Liang, Shen, Che‐Kun James
Publicado 2022