Super-Resolution Fluorescence of Huntingtin Reveals Growth of Globular Species into Short Fibers and Coexistence of Distinct Aggregates

por Duim, Whitney C., Jiang, Yan, Shen, Koning, Frydman, Judith, Moerner, W. E.
Publicado 2014

Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates

por Galaz-Montoya, Jesús G., Shahmoradian, Sarah H., Shen, Koning, Frydman, Judith, Chiu, Wah
Publicado 2021

Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans

por Calculli, Giuseppe, Lee, Hyun Ju, Shen, Koning, Pham, Uyen, Herholz, Marija, Trifunovic, Aleksandra, Dillin, Andrew, Vilchez, David
Publicado 2021

Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract

por Shen, Koning, Calamini, Barbara, Fauerbach, Jonathan A, Ma, Boxue, Shahmoradian, Sarah H, Serrano Lachapel, Ivana L, Chiu, Wah, Lo, Donald C, Frydman, Judith
Publicado 2016

Disease-related Huntingtin seeding activities in cerebrospinal fluids of Huntington’s disease patients

por Lee, C. Y. Daniel, Wang, Nan, Shen, Koning, Stricos, Matthew, Langfelder, Peter, Cheon, Kristina H., Cortés, Etty P., Vinters, Harry V., Vonsattel, Jean Paul, Wexler, Nancy S., Damoiseaux, Robert, Frydman, Judith, Yang, X. William
Publicado 2020

Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies

por Shen, Koning, Gamerdinger, Martin, Chan, Rebecca, Gense, Karina, Martin, Esther M., Sachs, Nadine, Knight, Patrick D., Schlömer, Renate, Calabrese, Antonio N., Stewart, Katie L., Leiendecker, Lukas, Baghel, Ankit, Radford, Sheena E., Frydman, Judith, Deuerling, Elke
Publicado 2019

Cross-species screening platforms identify EPS-8 as a critical link for mitochondrial stress and actin stabilization

por Moehle, Erica A., Higuchi-Sanabria, Ryo, Tsui, C. Kimberly, Homentcovschi, Stefan, Tharp, Kevin M., Zhang, Hanlin, Chi, Hannah, Joe, Larry, de los Rios Rogers, Mattias, Sahay, Arushi, Kelet, Naame, Benitez, Camila, Bar-Ziv, Raz, Garcia, Gilberto, Shen, Koning, Frankino, Phillip A., Schinzel, Robert T., Shalem, Ophir, Dillin, Andrew
Publicado 2021

Lysosomal recycling of amino acids affects ER quality control

por Higuchi-Sanabria, Ryo, Shen, Koning, Kelet, Naame, Frankino, Phillip A., Durieux, Jenni, Bar-Ziv, Raz, Sing, Cierra N., Garcia, Enrique J., Homentcovschi, Stefan, Sanchez, Melissa, Wu, Rui, Tronnes, Sarah U., Joe, Larry, Webster, Brant, Ahilon-Jeronimo, Alex, Monshietehadi, Samira, Dallarda, Sofia, Pender, Corinne, Pon, Liza A., Zoncu, Roberto, Dillin, Andrew
Publicado 2020