Breaching the Castle Walls: Hyaluronan Depletion as a Therapeutic Approach to Cancer Therapy

por Shepard, H. Michael
Publicado 2015

Therapeutic Targeting of Hyaluronan in the Tumor Stroma

por Kultti, Anne, Li, Xiaoming, Jiang, Ping, Thompson, Curtis B., Frost, Gregory I., Shepard, H. Michael
Publicado 2012

KIAA1199 expression and hyaluronan degradation colocalize in multiple sclerosis lesions

por Marella, Mathieu, Jadin, Laurence, Keller, Gilbert A, Sugarman, Barry J, Frost, Gregory I, Shepard, H Michael
Publicado 2018

Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen-induced arthritis in combination with tumour necrosis factor blockade

por Gompels, Luke L, Malik, Nasser M, Madden, Leigh, Jin, Pei, Feldmann, Marc, Shepard, H Michael, Paleolog, Ewa M
Publicado 2011

Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis

por Jin, Pei, Zhang, Juan, Sumariwalla, Percy F, Ni, Irene, Jorgensen, Brett, Crawford, Damian, Phillips, Suzanne, Feldmann, Marc, Shepard, H Michael, Paleolog, Ewa M
Publicado 2008

Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours

por Infante, Jeffrey R, Korn, Ronald L, Rosen, Lee S, LoRusso, Patricia, Dychter, Samuel S, Zhu, Joy, Maneval, Daniel C, Jiang, Ping, Shepard, H Michael, Frost, Gregory, Von Hoff, Daniel D, Borad, Mitesh J, Ramanathan, Ramesh K
Publicado 2018

Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours

por Infante, Jeffrey R, Korn, Ronald L, Rosen, Lee S, LoRusso, Patricia, Dychter, Samuel S, Zhu, Joy, Maneval, Daniel C, Jiang, Ping, Shepard, H Michael, Frost, Gregory, Von Hoff, Daniel D, Borad, Mitesh J, Ramanathan, Ramesh K
Publicado 2018

The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44

por Zhao, Chunmei, Thompson, Benjamin J., Chen, Kelly, Gao, Feng, Blouw, Barbara, Marella, Mathieu, Zimmerman, Susan, Kimbler, Trevor, Garrovillo, Sheryl, Bahn, Jesse, Huang, Lei, Huang, Zhongdong, Shepard, H. Michael, Rosengren, Sanna, Thanos, Christopher D., Maneval, Daniel C.
Publicado 2019

Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment

por Kultti, Anne, Zhao, Chunmei, Singha, Netai C., Zimmerman, Susan, Osgood, Ryan J., Symons, Rebecca, Jiang, Ping, Li, Xiaoming, Thompson, Curtis B., Infante, Jeffrey R., Jacobetz, Michael A., Tuveson, David A., Frost, Gregory I., Shepard, H. Michael, Huang, Zhongdong
Publicado 2014

PH20 is not expressed in murine CNS and oligodendrocyte precursor cells

por Marella, Mathieu, Ouyang, Joe, Zombeck, Jonathan, Zhao, Chunmei, Huang, Lei, Connor, Robert J., Phan, Kim B., Jorge, Michael C., Printz, Marie A., Paladini, Rudolph D., Gelb, Arnold B., Huang, Zhongdong, Frost, Gregory I., Sugarman, Barry J., Steinman, Lawrence, Wei, Ge, Shepard, H. Michael, Maneval, Daniel C., Lapinskas, Paula J.
Publicado 2017