Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease

por Fennema, Diede, Phillips, Ian R., Shephard, Elizabeth A.
Publicado 2016

Clinical utility gene card for: Trimethylaminuria – update 2014

por Shephard, Elizabeth A, Treacy, Eileen P, Phillips, Ian R
Publicado 2015

Metabolomic and transcriptomic analyses of Fmo5(-/)(- )mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein r...

por Phillips, Ian R., Veeravalli, Sunil, Khadayate, Sanjay, Shephard, Elizabeth A.
Publicado 2023

A highly sensitive liquid chromatography electrospray ionization mass spectrometry method for quantification of TMA, TMAO and creatinine in mouse urine

por Veeravalli, Sunil, Karu, Kersti, Phillips, Ian R., Shephard, Elizabeth A.
Publicado 2017

Recognizing sinonasal cancer in primary care: a matched case–control study using electronic records

por Khan, Tuba, El-Sockary, Yusera, Hamilton, William T, Shephard, Elizabeth A
Publicado 2021

Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data

por Bailey, Sarah ER, Ukoumunne, Obioha C, Shephard, Elizabeth A, Hamilton, Willie
Publicado 2017

Intra-abdominal cancer risk with abdominal pain: a prospective cohort primary care study

por Price, Sarah J, Gibson, Niamh, Hamilton, William T, King, Angela, Shephard, Elizabeth A
Publicado 2022

Diagnoses after newly recorded abdominal pain in primary care: observational cohort study

por Price, Sarah J, Gibson, Niamh, Hamilton, William T, Bostock, Jennifer, Shephard, Elizabeth A
Publicado 2022

Effect of Flavin-Containing Monooxygenase Genotype, Mouse Strain, and Gender on Trimethylamine N-oxide Production, Plasma Cholesterol Concentration, and an Index of Atherosclerosis

por Veeravalli, Sunil, Karu, Kersti, Scott, Flora, Fennema, Diede, Phillips, Ian R., Shephard, Elizabeth A.
Publicado 2018

Quantifying the impact of pre-existing conditions on the stage of oesophagogastric cancer at diagnosis: a primary care cohort study using electronic medical records

por Quiroga, Myra, Shephard, Elizabeth A, Mounce, Luke T A, Carney, Madeline, Hamilton, William T, Price, Sarah J
Publicado 2020

Clinical features of bowel disease in patients aged <50 years in primary care: a large case-control study

por Stapley, Sally A, Rubin, Greg P, Alsina, Deborah, Shephard, Elizabeth A, Rutter, Matthew D, Hamilton, William T
Publicado 2017

A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments

por Dona, Anthony C., Kyriakides, Michael, Scott, Flora, Shephard, Elizabeth A., Varshavi, Dorsa, Veselkov, Kirill, Everett, Jeremy R.
Publicado 2016

Metabolism and Pharmacokinetics of the Anti-Tuberculosis Drug Ethionamide in a Flavin-Containing Monooxygenase Null Mouse

por Palmer, Amy L., Leykam, Virginia L., Larkin, Andrew, Krueger, Sharon K., Phillips, Ian R., Shephard, Elizabeth A., Williams, David E.
Publicado 2012

Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5 (−/−) mice, decreases plasma cholesterol and epididymal fat deposition

por Veeravalli, Sunil, Varshavi, Dorsa, Scott, Flora H., Varshavi, Dorna, Pullen, Frank S., Veselkov, Kirill, Phillips, Ian R., Everett, Jeremy R., Shephard, Elizabeth A.
Publicado 2022

Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria

por Scott, Flora, Gonzalez Malagon, Sandra G., O’Brien, Brett A., Fennema, Diede, Veeravalli, Sunil, Coveney, Clarissa R., Phillips, Ian R., Shephard, Elizabeth A.
Publicado 2017

Metabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice

por Varshavi, Dorsa, Scott, Flora H., Varshavi, Dorna, Veeravalli, Sunil, Phillips, Ian R., Veselkov, Kirill, Strittmatter, Nicole, Takats, Zoltan, Shephard, Elizabeth A., Everett, Jeremy R.
Publicado 2018

The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing

por Gonzalez Malagon, Sandra G., Melidoni, Anna N., Hernandez, Diana, Omar, Bilal A., Houseman, Lyndsey, Veeravalli, Sunil, Scott, Flora, Varshavi, Dorsa, Everett, Jeremy, Tsuchiya, Yugo, Timms, John F., Phillips, Ian R., Shephard, Elizabeth A.
Publicado 2015