Structure of Pseudomonas aeruginosa inosine 5′-monophosphate dehydrogenase

por Rao, Vincenzo A., Shepherd, Sharon M., Owen, Richard, Hunter, William N.
Publicado 2013

The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system

por Rao, Vincenzo A., Shepherd, Sharon M., English, Grant, Coulthurst, Sarah J., Hunter, William N.
Publicado 2011

Pseudomonas aeruginosa 4-Amino-4-Deoxychorismate Lyase: Spatial Conservation of an Active Site Tyrosine and Classification of Two Types of Enzyme

por O'Rourke, Patrick E. F., Eadsforth, Thomas C., Fyfe, Paul K., Shepherd, Sharon M., Hunter, William N.
Publicado 2011

Trypanosoma cruzi Phosphomannomutase and Guanosine Diphosphate-Mannose Pyrophosphorylase Ligandability Assessment

por Zmuda, Filip, Shepherd, Sharon M., Ferguson, Michael A. J., Gray, David W., Torrie, Leah S., De Rycker, Manu
Publicado 2019

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening

por Prakash, Ohm, Führing, Jana, Post, John, Shepherd, Sharon M., Eadsforth, Thomas C., Gray, David, Fedorov, Roman, Routier, Françoise H.
Publicado 2019

Crystal Structures of Penicillin-Binding Protein 3 from Pseudomonas aeruginosa: Comparison of Native and Antibiotic-Bound Forms

por Sainsbury, Sarah, Bird, Louise, Rao, Vincenzo, Shepherd, Sharon M., Stuart, David I., Hunter, William N., Owens, Raymond J., Ren, Jingshan
Publicado 2011

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay

por Zmuda, Filip, Sastry, Lalitha, Shepherd, Sharon M., Jones, Deuan, Scott, Alison, Craggs, Peter D., Cortes, Alvaro, Gray, David W., Torrie, Leah S., De Rycker, Manu
Publicado 2019

Structural insights into mechanism and specificity of O-GlcNAc transferase

por Clarke, Andrew J, Hurtado-Guerrero, Ramon, Pathak, Shalini, Schüttelkopf, Alexander W, Borodkin, Vladimir, Shepherd, Sharon M, Ibrahim, Adel F M, van Aalten, Daan M F
Publicado 2008

Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase

por Milne, Rachel, Wiedemar, Natalie, Corpas-Lopez, Victoriano, Moynihan, Eoin, Wall, Richard J., Dawson, Alice, Robinson, David A., Shepherd, Sharon M., Smith, Robert J., Hallyburton, Irene, Post, John M., Dowers, Karen, Torrie, Leah S., Gilbert, Ian H., Baragaña, Beatriz, Patterson, Stephen, Wyllie, Susan
Publicado 2022

Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase

por Torrie, Leah S., Robinson, David A., Thomas, Michael G., Hobrath, Judith V., Shepherd, Sharon M., Post, John M., Ko, Eun-Jung, Ferreira, Rafael Alves, Mackenzie, Claire J., Wrobel, Karolina, Edwards, Darren P., Gilbert, Ian H., Gray, David W., Fairlamb, Alan H., De Rycker, Manu
Publicado 2020

Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention

por Summers, Robert L., Pasaje, Charisse Flerida A., Pisco, Joao P., Striepen, Josefine, Luth, Madeline R., Kumpornsin, Krittikorn, Carpenter, Emma F., Munro, Justin T., Lin, De, Plater, Andrew, Punekar, Avinash S., Shepherd, Andrew M., Shepherd, Sharon M., Vanaerschot, Manu, Murithi, James M., Rubiano, Kelly, Akidil, Aslı, Ottilie, Sabine, Mittal, Nimisha, Dilmore, A. Hazel, Won, Madalyn, Mandt, Rebecca E.K., McGowen, Kerry, Owen, Edward, Walpole, Chris, Llinás, Manuel, Lee, Marcus C.S., Winzeler, Elizabeth A., Fidock, David A., Gilbert, Ian H., Wirth, Dyann F., Niles, Jacquin C., Baragaña, Beatriz, Lukens, Amanda K.
Publicado 2022

Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs

por Green, Simon R., Davis, Susan H., Damerow, Sebastian, Engelhart, Curtis A., Mathieson, Michael, Baragaña, Beatriz, Robinson, David A., Tamjar, Jevgenia, Dawson, Alice, Tamaki, Fabio K., Buchanan, Kirsteen I., Post, John, Dowers, Karen, Shepherd, Sharon M., Jansen, Chimed, Zuccotto, Fabio, Gilbert, Ian H., Epemolu, Ola, Riley, Jennifer, Stojanovski, Laste, Osuna-Cabello, Maria, Pérez-Herrán, Esther, Rebollo, María José, Guijarro López, Laura, Casado Castro, Patricia, Camino, Isabel, Kim, Heather C., Bean, James M., Nahiyaan, Navid, Rhee, Kyu Y., Wang, Qinglan, Tan, Vee Y., Boshoff, Helena I. M., Converse, Paul J., Li, Si-Yang, Chang, Yong S., Fotouhi, Nader, Upton, Anna M., Nuermberger, Eric L., Schnappinger, Dirk, Read, Kevin D., Encinas, Lourdes, Bates, Robert H., Wyatt, Paul G., Cleghorn, Laura A. T.
Publicado 2022

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

por Baragaña, Beatriz, Forte, Barbara, Choi, Ryan, Nakazawa Hewitt, Stephen, Bueren-Calabuig, Juan A., Pisco, João Pedro, Peet, Caroline, Dranow, David M., Robinson, David A., Jansen, Chimed, Norcross, Neil R., Vinayak, Sumiti, Anderson, Mark, Brooks, Carrie F., Cooper, Caitlin A., Damerow, Sebastian, Delves, Michael, Dowers, Karen, Duffy, James, Edwards, Thomas E., Hallyburton, Irene, Horst, Benjamin G., Hulverson, Matthew A., Ferguson, Liam, Jiménez-Díaz, María Belén, Jumani, Rajiv S., Lorimer, Donald D., Love, Melissa S., Maher, Steven, Matthews, Holly, McNamara, Case W., Miller, Peter, O’Neill, Sandra, Ojo, Kayode K., Osuna-Cabello, Maria, Pinto, Erika, Post, John, Riley, Jennifer, Rottmann, Matthias, Sanz, Laura M., Scullion, Paul, Sharma, Arvind, Shepherd, Sharon M., Shishikura, Yoko, Simeons, Frederick R. C., Stebbins, Erin E., Stojanovski, Laste, Straschil, Ursula, Tamaki, Fabio K., Tamjar, Jevgenia, Torrie, Leah S., Vantaux, Amélie, Witkowski, Benoît, Wittlin, Sergio, Yogavel, Manickam, Zuccotto, Fabio, Angulo-Barturen, Iñigo, Sinden, Robert, Baum, Jake, Gamo, Francisco-Javier, Mäser, Pascal, Kyle, Dennis E., Winzeler, Elizabeth A., Myler, Peter J., Wyatt, Paul G., Floyd, David, Matthews, David, Sharma, Amit, Striepen, Boris, Huston, Christopher D., Gray, David W., Fairlamb, Alan H., Pisliakov, Andrei V., Walpole, Chris, Read, Kevin D., Van Voorhis, Wesley C., Gilbert, Ian H.
Publicado 2019