Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta

por Sheppard, Olivia, Coleman, Michael P., Durrant, Claire S.
Publicado 2019

Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling

por Durrant, Claire S., Ruscher, Karsten, Sheppard, Olivia, Coleman, Michael P., Özen, Ilknur
Publicado 2020

Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21

por Ruparelia, Aarti, Wiseman, Frances, Sheppard, Olivia, Tybulewicz, Victor L.J., Fisher, Elizabeth M.C.
Publicado 2010

Mouse Models of Aneuploidy

por Sheppard, Olivia, Wiseman, Frances K., Ruparelia, Aarti, Tybulewicz, Victor L. J., Fisher, Elizabeth M. C.
Publicado 2012

Generation of a panel of antibodies against proteins encoded on human chromosome 21

por Wiseman, Frances K, Sheppard, Olivia, Linehan, Jacqueline M, Brandner, Sebastian, Tybulewicz, Victor LJ, Fisher, Elizabeth MC
Publicado 2010

Optically Robust and Biocompatible Mechanosensitive Upconverting Nanoparticles

por Lay, Alice, Sheppard, Olivia H., Siefe, Chris, McLellan, Claire A., Mehlenbacher, Randy D., Fischer, Stefan, Goodman, Miriam B., Dionne, Jennifer A.
Publicado 2019

Altered regulation of tau phosphorylation in a mouse model of down syndrome aging

por Sheppard, Olivia, Plattner, Florian, Rubin, Anna, Slender, Amy, Linehan, Jacqueline M., Brandner, Sebastian, Tybulewicz, Victor L.J., Fisher, Elizabeth M.C., Wiseman, Frances K.
Publicado 2012

Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue

por Miller, Lauren V. C., Mukadam, Aamir S., Durrant, Claire S., Vaysburd, Marina J., Katsinelos, Taxiarchis, Tuck, Benjamin J., Sanford, Sophie, Sheppard, Olivia, Knox, Claire, Cheng, Shi, James, Leo C., Coleman, Michael P., McEwan, William A.
Publicado 2021

Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons

por Qiu, Jing, McQueen, Jamie, Bilican, Bilada, Dando, Owen, Magnani, Dario, Punovuori, Karolina, Selvaraj, Bhuvaneish T, Livesey, Matthew, Haghi, Ghazal, Heron, Samuel, Burr, Karen, Patani, Rickie, Rajan, Rinku, Sheppard, Olivia, Kind, Peter C, Simpson, T Ian, Tybulewicz, Victor LJ, Wyllie, David JA, Fisher, Elizabeth MC, Lowell, Sally, Chandran, Siddharthan, Hardingham, Giles E
Publicado 2016

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML

por Basheer, Faisal, Giotopoulos, George, Meduri, Eshwar, Yun, Haiyang, Mazan, Milena, Sasca, Daniel, Gallipoli, Paolo, Marando, Ludovica, Gozdecka, Malgorzata, Asby, Ryan, Sheppard, Olivia, Dudek, Monika, Bullinger, Lars, Döhner, Hartmut, Dillon, Richard, Freeman, Sylvie, Ottmann, Oliver, Burnett, Alan, Russell, Nigel, Papaemmanuil, Elli, Hills, Robert, Campbell, Peter, Vassiliou, George S., Huntly, Brian J.P.
Publicado 2019

Massively Parallel Sequencing Reveals the Complex Structure of an Irradiated Human Chromosome on a Mouse Background in the Tc1 Model of Down Syndrome

por Gribble, Susan M., Wiseman, Frances K., Clayton, Stephen, Prigmore, Elena, Langley, Elizabeth, Yang, Fengtang, Maguire, Sean, Fu, Beiyuan, Rajan, Diana, Sheppard, Olivia, Scott, Carol, Hauser, Heidi, Stephens, Philip J., Stebbings, Lucy A., Ng, Bee Ling, Fitzgerald, Tomas, Quail, Michael A., Banerjee, Ruby, Rothkamm, Kai, Tybulewicz, Victor L. J., Fisher, Elizabeth M. C., Carter, Nigel P.
Publicado 2013

Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors

por Horton, Sarah J., Giotopoulos, George, Yun, Haiyang, Vohra, Shabana, Sheppard, Olivia, Bashford-Rogers, Rachael, Rashid, Mamunur, Clipson, Alexandra, Chan, Wai-In, Sasca, Daniel, Yiangou, Loukia, Osaki, Hikari, Basheer, Faisal, Gallipoli, Paolo, Burrows, Natalie, Erdem, Aysegul, Sybirna, Anastasiya, Foerster, Sarah, Zhao, Wanfeng, Sustic, Tonci, Harrison, Anna Petrunkina, Laurenti, Elisa, Okosun, Jessica, Hodson, Daniel, Wright, Penny, Smith, Ken G., Maxwell, Patrick, Fitzgibbon, Jude, Du, Ming Q., Adams, David J., Huntly, Brian J.P
Publicado 2017

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP

por Wiseman, Frances K, Pulford, Laura J, Barkus, Chris, Liao, Fan, Portelius, Erik, Webb, Robin, Chávez-Gutiérrez, Lucia, Cleverley, Karen, Noy, Sue, Sheppard, Olivia, Collins, Toby, Powell, Caroline, Sarell, Claire J, Rickman, Matthew, Choong, Xun, Tosh, Justin L, Siganporia, Carlos, Whittaker, Heather T, Stewart, Floy, Szaruga, Maria, Murphy, Michael P, Blennow, Kaj, de Strooper, Bart, Zetterberg, Henrik, Bannerman, David, Holtzman, David M, Tybulewicz, Victor L J, Fisher, Elizabeth M C
Publicado 2018