Liquid biopsies in pediatric oncology: opportunities and obstacles

por Sundby, R. Taylor, Pan, Alex, Shern, Jack F.
Publicado 2022

The Role of Polycomb Repressive Complex in Malignant Peripheral Nerve Sheath Tumor

por Zhang, Xiyuan, Murray, Béga, Mo, George, Shern, Jack F.
Publicado 2020

Protocol for using single-cell sequencing to study the heterogeneity of NF1 nerve sheath tumors from clinical biospecimens

por Zhang, Xiyuan, Gopalan, Vishaka, Syed, Neeraja, Hannenhalli, Sridhar, Shern, Jack F.
Publicado 2023

Genetic Characterization, Current Model Systems and Prognostic Stratification in PAX Fusion-Negative vs. PAX Fusion-Positive Rhabdomyosarcoma

por Dehner, Carina A., Armstrong, Amy E., Yohe, Marielle, Shern, Jack F., Hirbe, Angela C.
Publicado 2021

Loss of CASZ1 tumor suppressor linked to oncogenic subversion of neuroblastoma core regulatory circuitry

por Liu, Zhihui, Zhang, Xiyuan, Xu, Man, Lei, Haiyan, Shern, Jack F., Thiele, Carol J.
Publicado 2022

Multiple Nf1 Schwann cell populations reprogram the plexiform neurofibroma tumor microenvironment

por Kershner, Leah J., Choi, Kwangmin, Wu, Jianqiang, Zhang, Xiyuan, Perrino, Melissa, Salomonis, Nathan, Shern, Jack F., Ratner, Nancy
Publicado 2022

MYCN driven oncogenesis involves cooperation with WDR5 to activate canonical MYC targets and G9a to repress differentiation genes

por Liu, Zhihui, Zhang, Xiyuan, Xu, Man, Hong, Jason J., Ciardiello, Amanda, Lei, Haiyan, Shern, Jack F., Thiele, Carol J.
Publicado 2023

Targeting Wild-Type and Mutationally Activated FGFR4 in Rhabdomyosarcoma with the Inhibitor Ponatinib (AP24534)

por Li, Samuel Q., Cheuk, Adam T., Shern, Jack F., Song, Young K., Hurd, Laura, Liao, Hongling, Wei, Jun S., Khan, Javed
Publicado 2013

Kras activation in p53-deficient myoblasts results in high-grade sarcoma formation with impaired myogenic differentiation

por McKinnon, Timothy, Venier, Rosemarie, Dickson, Brendan C., Kabaroff, Leah, Alkema, Manon, Chen, Li, Shern, Jack F., Yohe, Marielle E., Khan, Javed, Gladdy, Rebecca A.
Publicado 2015

Preclinical Development of Bivalent Chimeric Antigen Receptors Targeting Both CD19 and CD22

por Qin, Haiying, Ramakrishna, Sneha, Nguyen, Sang, Fountaine, Thomas J., Ponduri, Anusha, Stetler-Stevenson, Maryalice, Yuan, Constance M., Haso, Waleed, Shern, Jack F., Shah, Nirali N., Fry, Terry J.
Publicado 2018

Clonality and Evolutionary History of Rhabdomyosarcoma

por Chen, Li, Shern, Jack F., Wei, Jun S., Yohe, Marielle E., Song, Young K., Hurd, Laura, Liao, Hongling, Catchpoole, Daniel, Skapek, Stephen X., Barr, Frederic G., Hawkins, Douglas S., Khan, Javed
Publicado 2015

KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis

por Murgai, Meera, Ju, Wei, Eason, Matthew, Kline, Jessica, Beury, Daniel, Kaczanowska, Sabina, Miettinen, Markku M, Kruhlak, Michael, Lei, Haiyan, Shern, Jack F, Cherepanova, Olga A., Owens, Gary K, Kaplan, Rosandra N
Publicado 2017

CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG

por Liu, Zhihui, Zhang, Xiyuan, Lei, Haiyan, Lam, Norris, Carter, Sakereh, Yockey, Oliver, Xu, Max, Mendoza, Arnulfo, Hernandez, Edjay R., Wei, Jun S., Khan, Javed, Yohe, Marielle E., Shern, Jack F., Thiele, Carol J.
Publicado 2020

Transcriptome analysis of desmoplastic small round cell tumors identifies actionable therapeutic targets: a report from the Children’s Oncology Group

por Hingorani, Pooja, Dinu, Valentin, Zhang, Xiyuan, Lei, Haiyan, Shern, Jack F., Park, Jin, Steel, Jason, Rauf, Femina, Parham, David, Gastier-Foster, Julie, Hall, David, Hawkins, Douglas S., Skapek, Stephen X., Labaer, Joshua, McEachron, Troy A.
Publicado 2020

Preclinical testing of the glycogen synthase kinase-3β inhibitor tideglusib for rhabdomyosarcoma

por Bharathy, Narendra, Svalina, Matthew N., Settelmeyer, Teagan P., Cleary, Megan M., Berlow, Noah E., Airhart, Susan D., Xiang, Sunny, Keck, James, Hayden, James B., Shern, Jack F., Mansoor, Atiya, Lathara, Melvin, Srinivasa, Ganapati, Langenau, David M., Keller, Charles
Publicado 2017

Chemical genomics reveals histone deacetylases are required for core regulatory transcription

por Gryder, Berkley E., Wu, Lei, Woldemichael, Girma M., Pomella, Silvia, Quinn, Taylor R., Park, Paul M. C., Cleveland, Abigail, Stanton, Benjamin Z., Song, Young, Rota, Rossella, Wiest, Olaf, Yohe, Marielle E., Shern, Jack F., Qi, Jun, Khan, Javed
Publicado 2019

Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor

por Zhang, Xiyuan, Lou, Hannah E., Gopalan, Vishaka, Liu, Zhihui, Jafarah, Hilda M., Lei, Haiyan, Jones, Paige, Sayers, Carly M., Yohe, Marielle E., Chittiboina, Prashant, Widemann, Brigitte C., Thiele, Carol J., Kelly, Michael C., Hannenhalli, Sridhar, Shern, Jack F.
Publicado 2022

4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors

por Long, Adrienne H., Haso, Waleed M., Shern, Jack F., Wanhainen, Kelsey M., Murgai, Meera, Ingaramo, Maria, Smith, Jillian P., Walker, Alec J., Kohler, M. Eric, Venkateshwara, Vikas R., Kaplan, Rosandra N., Patterson, George H., Fry, Terry J., Orentas, Rimas J., Mackall, Crystal L.
Publicado 2015

Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma

por Gryder, Berkley E., Pomella, Silvia, Sayers, Carly, Wu, Xiaoli S., Song, Young, Chiarella, Anna M., Bagchi, Sukriti, Chou, Hsien-Chao, Sinniah, Ranu S., Walton, Ashley, Wen, Xinyu, Rota, Rossella, Hathaway, Nathaniel A., Zhao, Keji, Chen, Jiji, Vakoc, Christopher R., Shern, Jack F., Stanton, Benjamin Z., Khan, Javed
Publicado 2019

Defining the Extracellular Matrix of Rhabdomyosarcoma

por Lian, Xiaolei, Bond, J. Steffan, Bharathy, Narendra, Boudko, Sergei P., Pokidysheva, Elena, Shern, Jack F., Lathara, Melvin, Sasaki, Takako, Settelmeyer, Teagan, Cleary, Megan M., Bajwa, Ayeza, Srinivasa, Ganapati, Hartley, Christopher P., Bächinger, Hans Peter, Mansoor, Atiya, Gultekin, Sakir H., Berlow, Noah E., Keller, Charles
Publicado 2021