PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila

por Shiba-Fukushima, Kahori, Inoshita, Tsuyoshi, Hattori, Nobutaka, Imai, Yuzuru
Publicado 2014

Twin CHCH Proteins, CHCHD2, and CHCHD10: Key Molecules of Parkinson’s Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia

por Imai, Yuzuru, Meng, Hongrui, Shiba-Fukushima, Kahori, Hattori, Nobutaka
Publicado 2019

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

por Shiba-Fukushima, Kahori, Imai, Yuzuru, Yoshida, Shigeharu, Ishihama, Yasushi, Kanao, Tomoko, Sato, Shigeto, Hattori, Nobutaka
Publicado 2012

Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome

por Hosaka, Yuka, Inoshita, Tsuyoshi, Shiba-Fukushima, Kahori, Cui, Changxu, Arano, Taku, Imai, Yuzuru, Hattori, Nobutaka
Publicado 2017

Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson’s disease

por Imai, Yuzuru, Inoshita, Tsuyoshi, Meng, Hongrui, Shiba-Fukushima, Kahori, Hara, Kiyotaka Y., Sawamura, Naoya, Hattori, Nobutaka
Publicado 2019

Parkinson disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila

por Inoshita, Tsuyoshi, Liu, Jun-Yi, Taniguchi, Daisuke, Ishii, Ryota, Shiba-Fukushima, Kahori, Hattori, Nobutaka, Imai, Yuzuru
Publicado 2022

Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation

por Liu, Jun-Yi, Inoshita, Tsuyoshi, Shiba-Fukushima, Kahori, Yoshida, Shigeharu, Ogata, Kosuke, Ishihama, Yasushi, Imai, Yuzuru, Hattori, Nobutaka
Publicado 2022

A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling

por Shiba-Fukushima, Kahori, Inoshita, Tsuyoshi, Sano, Osamu, Iwata, Hidehisa, Ishikawa, Kei-ichi, Okano, Hideyuki, Akamatsu, Wado, Imai, Yuzuru, Hattori, Nobutaka
Publicado 2020

Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering

por Shiba-Fukushima, Kahori, Arano, Taku, Matsumoto, Gen, Inoshita, Tsuyoshi, Yoshida, Shigeharu, Ishihama, Yasushi, Ryu, Kwon-Yul, Nukina, Nobuyuki, Hattori, Nobutaka, Imai, Yuzuru
Publicado 2014

Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c

por Meng, Hongrui, Yamashita, Chikara, Shiba-Fukushima, Kahori, Inoshita, Tsuyoshi, Funayama, Manabu, Sato, Shigeto, Hatta, Tomohisa, Natsume, Tohru, Umitsu, Masataka, Takagi, Junichi, Imai, Yuzuru, Hattori, Nobutaka
Publicado 2017

Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease

por Yamaguchi, Akihiro, Ishikawa, Kei-ichi, Inoshita, Tsuyoshi, Shiba-Fukushima, Kahori, Saiki, Shinji, Hatano, Taku, Mori, Akio, Oji, Yutaka, Okuzumi, Ayami, Li, Yuanzhe, Funayama, Manabu, Imai, Yuzuru, Hattori, Nobutaka, Akamatsu, Wado
Publicado 2020

Pathophysiological evaluation of the LRRK2 G2385R risk variant for Parkinson’s disease

por Tezuka, Toshiki, Taniguchi, Daisuke, Sano, Mariko, Shimada, Tomoyo, Oji, Yutaka, Tsunemi, Taiji, Ikeda, Aya, Li, Yuanzhe, Yoshino, Hiroyo, Ogata, Jun, Shiba-Fukushima, Kahori, Funayama, Manabu, Nishioka, Kenya, Imai, Yuzuru, Hattori, Nobutaka
Publicado 2022

α‐Synuclein V15A Variant in Familial Parkinson's Disease Exhibits a Weaker Lipid‐Binding Property

por Daida, Kensuke, Shimonaka, Shotaro, Shiba‐Fukushima, Kahori, Ogata, Jun, Yoshino, Hiroyo, Okuzumi, Ayami, Hatano, Taku, Motoi, Yumiko, Hirunagi, Tomoki, Katsuno, Masahisa, Shindou, Hideo, Funayama, Manabu, Nishioka, Kenya, Hattori, Nobutaka, Imai, Yuzuru
Publicado 2022

Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations

por Kano, Masayoshi, Takanashi, Masashi, Oyama, Genko, Yoritaka, Asako, Hatano, Taku, Shiba-Fukushima, Kahori, Nagai, Makiko, Nishiyama, Kazutoshi, Hasegawa, Kazuko, Inoshita, Tsuyoshi, Ishikawa, Kei-ichi, Akamatsu, Wado, Imai, Yuzuru, Bolognin, Silvia, Schwamborn, Jens Christian, Hattori, Nobutaka
Publicado 2020

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

por Okatsu, Kei, Oka, Toshihiko, Iguchi, Masahiro, Imamura, Kenji, Kosako, Hidetaka, Tani, Naoki, Kimura, Mayumi, Go, Etsu, Koyano, Fumika, Funayama, Manabu, Shiba-Fukushima, Kahori, Sato, Shigeto, Shimizu, Hideaki, Fukunaga, Yuko, Taniguchi, Hisaaki, Komatsu, Masaaki, Hattori, Nobutaka, Mihara, Katsuyoshi, Tanaka, Keiji, Matsuda, Noriyuki
Publicado 2012

Parkinson’s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling

por Mori, Akio, Hatano, Taku, Inoshita, Tsuyoshi, Shiba-Fukushima, Kahori, Koinuma, Takahiro, Meng, Hongrui, Kubo, Shin-ichiro, Spratt, Spencer, Cui, Changxu, Yamashita, Chikara, Miki, Yoshimi, Yamamoto, Kei, Hirabayashi, Tetsuya, Murakami, Makoto, Takahashi, Yoshikazu, Shindou, Hideo, Nonaka, Takashi, Hasegawa, Masato, Okuzumi, Ayami, Imai, Yuzuru, Hattori, Nobutaka
Publicado 2019