SP2-3 The impact of the COVID-19 global pandemic on oncology drug development, clinical research and R&D in Japan

por Shimizu, Toshio
Publicado 2021

Asymmetrical putaminal atrophy in parkinsonism-predominant multiple system atrophy (MSA-P): A case report

por Mori, Koichiro, Yagishita, Akira, Shimizu, Toshio
Publicado 2023

Sensory Gating during Voluntary Finger Movement in Amyotrophic Lateral Sclerosis with Sensory Cortex Hyperexcitability

por Shimizu, Toshio, Nakayama, Yuki, Bokuda, Kota, Takahashi, Kazushi
Publicado 2023

Abnormal Nerve Conduction Study Findings Indicating the Existence of Peripheral Neuropathy in Multiple Sclerosis and Neuromyelitis Optica

por Warabi, Yoko, Yamazaki, Mikihiro, Shimizu, Toshio, Nagao, Masahiro
Publicado 2013

Wernicke's Encephalopathy in a Patient with Peptic Ulcer Disease

por Uruha, Akinori, Shimizu, Toshio, Katoh, Tomoji, Yamasaki, Yasushi, Matsubara, Shiro
Publicado 2011

Pseudomyopathic Changes in Needle Electromyography in Lambert-Eaton Myasthenic Syndrome

por Komatsu, Teppei, Bokuda, Kota, Shimizu, Toshio, Komori, Tetsuo, Koide, Reiji
Publicado 2013

Emerging PD-1/PD-L1 targeting immunotherapy in non-small cell lung cancer: Current status and future perspective in Japan, US, EU, and China

por Mizuno, Takaaki, Katsuya, Yuki, Sato, Jun, Koyama, Takafumi, Shimizu, Toshio, Yamamoto, Noboru
Publicado 2022

Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature review

por Kawama, Kentaro, Shimazaki, Rui, Sunami, Yoko, Miyakoshi, Natsuki, Tobisawa, Shinsuke, Shimizu, Toshio, Takahashi, Kazushi
Publicado 2023

Phase I and Pharmacokinetic Study of HER2-targeted rhuMAb 2C4 (Pertuzumab, RO4368451) in Japanese Patients with Solid Tumors

por Yamamoto, Noboru, Yamada, Yasuhide, Fujiwara, Yutaka, Yamada, Kazuhiko, Fujisaka, Yasuhito, Shimizu, Toshio, Tamura, Tomohide
Publicado 2009

Prevalence of psychological distress, quality of life, and satisfaction among patients and family members following comprehensive genomic profiling testing: Protocol of the Quality...

por Nishino, Makoto, Fujimori, Maiko, Koyama, Takafumi, Hirata, Makoto, Tanabe, Noriko, Shimizu, Toshio, Yamamoto, Noboru, Uchitomi, Yosuke
Publicado 2023

Impact of Hepatitis Virus on the Feasibility and Efficacy of Anticancer Agents in Patients With Hepatocellular Carcinoma in Phase I Clinical Trials

por Koyama, Takafumi, Kondo, Shunsuke, Shimizu, Toshio, Fujiwara, Yutaka, Morizane, Chigusa, Sakamoto, Yasunari, Okusaka, Takuji, Yamamoto, Noboru
Publicado 2019

Infection risk with PI3K-AKT-mTOR pathway inhibitors and immune checkpoint inhibitors in patients with advanced solid tumours in phase I clinical trials

por Fujiwara, Yutaka, Kuchiba, Aya, Koyama, Takafumi, Machida, Ryunosuke, Shimomura, Akihiko, Kitano, Shigehisa, Shimizu, Toshio, Yamamoto, Noboru
Publicado 2020

Phase 1 study of new formulation of patritumab (U3-1287) Process 2, a fully human anti-HER3 monoclonal antibody in combination with erlotinib in Japanese patients with advanced non...

por Shimizu, Toshio, Yonesaka, Kimio, Hayashi, Hidetoshi, Iwasa, Tsutomu, Haratani, Koji, Yamada, Hironori, Ohwada, Shoichi, Kamiyama, Emi, Nakagawa, Kazuhiko
Publicado 2017

Body Weight Gain Is Associated with the Disease Stage in Advanced Amyotrophic Lateral Sclerosis with Invasive Ventilation

por Nakayama, Yuki, Shimizu, Toshio, Matsuda, Chiharu, Haraguchi, Michiko, Hayashi, Kentaro, Bokuda, Kota, Nagao, Masahiro, Kawata, Akihiro, Takahashi, Kazushi
Publicado 2022

An early clinical trial of Salirasib, an oral RAS inhibitor, in Japanese patients with relapsed/refractory solid tumors

por Furuse, Junji, Kurata, Takayasu, Okano, Naohiro, Fujisaka, Yasuhito, Naruge, Daisuke, Shimizu, Toshio, Kitamura, Hiroshi, Iwasa, Tsutomu, Nagashima, Fumio, Nakagawa, Kazuhiko
Publicado 2018

Phase 1 study of telisotuzumab vedotin in Japanese patients with advanced solid tumors

por Fujiwara, Yutaka, Kenmotsu, Hirotsugu, Yamamoto, Noboru, Shimizu, Toshio, Yonemori, Kan, Ocampo, Christopher, Parikh, Apurvasena, Okubo, Sumiko, Fukasawa, Kazuteru, Murakami, Haruyasu
Publicado 2021

Body weight variation predicts disease progression after invasive ventilation in amyotrophic lateral sclerosis

por Nakayama, Yuki, Shimizu, Toshio, Matsuda, Chiharu, Haraguchi, Michiko, Hayashi, Kentaro, Bokuda, Kota, Nagao, Masahiro, Kawata, Akihiro, Ishikawa-Takata, Kazuko, Isozaki, Eiji
Publicado 2019

Overcoming the impact of the COVID‐19 pandemic on oncology early phase trials and drug development in Asia—Experiences and perspectives of the Asian Oncology Early Phase 1 Consorti...

por Shimizu, Toshio, Kim, Dong‐Wan, Loong, Herbert H., Lin, Chia‐Chi, Ng, Matthew CH, Yamamoto, Noboru, Ma, Brigette, Tan, Daniel SW
Publicado 2021

Aberrant DNA hypermethylation reduces the expression of the desmosome-related molecule periplakin in esophageal squamous cell carcinoma

por Otsubo, Takeshi, Hagiwara, Teruki, Tamura-Nakano, Miwa, Sezaki, Takuhito, Miyake, Oki, Hinohara, Chihaya, Shimizu, Toshio, Yamada, Kazuhiko, Dohi, Taeko, Kawamura, Yuki I
Publicado 2015

A first-in-Asian phase 1 study to evaluate safety, pharmacokinetics and clinical activity of VS-6063, a focal adhesion kinase (FAK) inhibitor in Japanese patients with advanced sol...

por Shimizu, Toshio, Fukuoka, Kazuya, Takeda, Masayuki, Iwasa, Tutomu, Yoshida, Takeshi, Horobin, Joanna, Keegan, Mitchell, Vaickus, Lou, Chavan, Ajit, Padval, Mahesh, Nakagawa, Kazuhiko
Publicado 2016