Imaging of cerebrovascular pathology in animal models of Alzheimer's disease

por Klohs, Jan, Rudin, Markus, Shimshek, Derya R., Beckmann, Nicolau
Publicado 2014

Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging

por Longo, Francesco, Russo, Isabella, Shimshek, Derya R., Greggio, Elisa, Morari, Michele
Publicado 2014

Excess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1

por Shimshek, Derya R., Schweizer, Tatjana, Schmid, Peter, van der Putten, P. Herman
Publicado 2012

The HSP70 Molecular Chaperone Is Not Beneficial in a Mouse Model of α-synucleinopathy

por Shimshek, Derya R., Mueller, Matthias, Wiessner, Christoph, Schweizer, Tatjana, van der Putten, P. Herman
Publicado 2010

Surfactant Secretion in LRRK2 Knock-Out Rats: Changes in Lamellar Body Morphology and Rate of Exocytosis

por Miklavc, Pika, Ehinger, Konstantin, Thompson, Kristin E., Hobi, Nina, Shimshek, Derya R., Frick, Manfred
Publicado 2014

Leucine-Rich Repeat Kinase 2 (Lrrk2)-Sensitive Na(+)/K(+) ATPase Activity in Dendritic Cells

por Hosseinzadeh, Zohreh, Singh, Yogesh, Shimshek, Derya R., van der Putten, Herman, Wagner, Carsten A., Lang, Florian
Publicado 2017

Leucine‐rich repeat kinase 2 (LRRK2) inhibitors differentially modulate glutamate release and Serine935 LRRK2 phosphorylation in striatal and cerebrocortical synaptosomes

por Mercatelli, Daniela, Bolognesi, Paolo, Frassineti, Martina, Pisanò, Clarissa A., Longo, Francesco, Shimshek, Derya R., Morari, Michele
Publicado 2019

Enhanced Odor Discrimination and Impaired Olfactory Memory by Spatially Controlled Switch of AMPA Receptors

por Shimshek, Derya R, Bus, Thorsten, Kim, Jinhyun, Mihaljevic, Andre, Mack, Volker, Seeburg, Peter H, Sprengel, Rolf, Schaefer, Andreas T
Publicado 2005

Different Forms of AMPA Receptor Mediated LTP and Their Correlation to the Spatial Working Memory Formation

por Shimshek, Derya R., Bus, Thorsten, Schupp, Bettina, Jensen, Vidar, Marx, Verena, Layer, Liliana E., Köhr, Georg, Sprengel, Rolf
Publicado 2017

Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease

por Hijazi, Sara, Heistek, Tim S., Scheltens, Philip, Neumann, Ulf, Shimshek, Derya R., Mansvelder, Huibert D., Smit, August B., van Kesteren, Ronald E.
Publicado 2019

Mutant Huntingtin Gene-Dose Impacts on Aggregate Deposition, DARPP32 Expression and Neuroinflammation in HdhQ150 Mice

por Young, Douglas, Mayer, Franziska, Vidotto, Nella, Schweizer, Tatjana, Berth, Ramon, Abramowski, Dorothee, Shimshek, Derya R., van der Putten, P. Herman, Schmid, Peter
Publicado 2013

BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology

por Peters, Finn, Salihoglu, Hazal, Rodrigues, Eva, Herzog, Etienne, Blume, Tanja, Filser, Severin, Dorostkar, Mario, Shimshek, Derya R., Brose, Nils, Neumann, Ulf, Herms, Jochen
Publicado 2018

Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945

por Beckmann, Nicolau, Giorgetti, Elisa, Neuhaus, Anna, Zurbruegg, Stefan, Accart, Nathalie, Smith, Paul, Perdoux, Julien, Perrot, Ludovic, Nash, Mark, Desrayaud, Sandrine, Wipfli, Peter, Frieauff, Wilfried, Shimshek, Derya R.
Publicado 2018

Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice

por Longo, Francesco, Mercatelli, Daniela, Novello, Salvatore, Arcuri, Ludovico, Brugnoli, Alberto, Vincenzi, Fabrizio, Russo, Isabella, Berti, Giulia, Mabrouk, Omar S., Kennedy, Robert T., Shimshek, Derya R., Varani, Katia, Bubacco, Luigi, Greggio, Elisa, Morari, Michele
Publicado 2017

Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model

por Beckmann, Nicolau, Neuhaus, Anna, Zurbruegg, Stefan, Volkmer, Pia, Patino, Claudia, Joller, Stefanie, Feuerbach, Dominik, Doelemeyer, Arno, Schweizer, Tatjana, Rudin, Stefan, Neumann, Ulf, Berth, Ramon, Frieauff, Wilfried, Gasparini, Fabrizio, Shimshek, Derya R.
Publicado 2023

Neuropathology in Mice Expressing Mouse Alpha-Synuclein

por Rieker, Claus, Dev, Kumlesh K., Lehnhoff, Katja, Barbieri, Samuel, Ksiazek, Iwona, Kauffmann, Sabine, Danner, Simone, Schell, Heinrich, Boden, Cindy, Ruegg, Markus A., Kahle, Philipp J., van der Putten, Herman, Shimshek, Derya R.
Publicado 2011

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

por Neumann, Ulf, Rueeger, Heinrich, Machauer, Rainer, Veenstra, Siem Jacob, Lueoend, Rainer M., Tintelnot-Blomley, Marina, Laue, Grit, Beltz, Karen, Vogg, Barbara, Schmid, Peter, Frieauff, Wilfried, Shimshek, Derya R., Staufenbiel, Matthias, Jacobson, Laura H.
Publicado 2015

High LRRK2 Levels Fail to Induce or Exacerbate Neuronal Alpha-Synucleinopathy in Mouse Brain

por Herzig, Martin C., Bidinosti, Michael, Schweizer, Tatjana, Hafner, Thomas, Stemmelen, Christine, Weiss, Andreas, Danner, Simone, Vidotto, Nella, Stauffer, Daniela, Barske, Carmen, Mayer, Franziska, Schmid, Peter, Rovelli, Giorgio, van der Putten, P. Herman, Shimshek, Derya R.
Publicado 2012

Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions

por Tanriöver, Gaye, Bacioglu, Mehtap, Schweighauser, Manuel, Mahler, Jasmin, Wegenast-Braun, Bettina M., Skodras, Angelos, Obermüller, Ulrike, Barth, Melanie, Kronenberg-Versteeg, Deborah, Nilsson, K. Peter R., Shimshek, Derya R., Kahle, Philipp J., Eisele, Yvonne S., Jucker, Mathias
Publicado 2020

Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice

por Shimshek, Derya R., Jacobson, Laura H., Kolly, Carine, Zamurovic, Natasa, Balavenkatraman, Kamal Kumar, Morawiec, Laurent, Kreutzer, Robert, Schelle, Juliane, Jucker, Mathias, Bertschi, Barbara, Theil, Diethilde, Heier, Annabelle, Bigot, Karine, Beltz, Karen, Machauer, Rainer, Brzak, Irena, Perrot, Ludovic, Neumann, Ulf
Publicado 2016