Mechanistic analysis of the enhanced RNAi activity by 6-mCEPh-purine at the 5′ end of the siRNA guide strand

por Brechin, Vincent, Shinohara, Fumikazu, Saito, Jun-ichi, Seitz, Hervé, Tomari, Yukihide
Publicado 2021

Structure-guided screening strategy combining surface plasmon resonance with nuclear magnetic resonance for identification of small-molecule Argonaute 2 inhibitors

por Harumoto, Toshimasa, Sato, Atsuko, Takayama, Yuki, Miyagi, Hikaru, Saito, Jun-ichi, Shinohara, Fumikazu
Publicado 2020

siRNA potency enhancement via chemical modifications of nucleotide bases at the 5′-end of the siRNA guide strand

por Shinohara, Fumikazu, Oashi, Taiji, Harumoto, Toshimasa, Nishikawa, Tomoyuki, Takayama, Yuki, Miyagi, Hikaru, Takahashi, Yuichi, Nakajima, Takahiro, Sawada, Takashi, Koda, Yasuo, Makino, Asana, Sato, Atsuko, Hamaguchi, Kaori, Suzuki, Michihiko, Yamamoto, Junichiro, Tomari, Yukihide, Saito, Jun-Ichi
Publicado 2021