Which patient will feel down, which will be happy? The need to study the genetic disposition of emotional states

por Sprangers, Mirjam A. G., Bartels, Meike, Veenhoven, Ruut, Baas, Frank, Martin, Nicholas G., Mosing, Miriam, Movsas, Benjamin, Ropka, Mary E., Shinozaki, Gen, Swaab, Dick
Publicado 2010

Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity

por Marra, Pedro S., Yamanashi, Takehiko, Crutchley, Kaitlyn J., Wahba, Nadia E., Anderson, Zoe-Ella M., Modukuri, Manisha, Chang, Gloria, Tran, Tammy, Iwata, Masaaki, Cho, Hyunkeun Ryan, Shinozaki, Gen
Publicado 2023

Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model

por Yamanashi, Takehiko, Iwata, Masaaki, Shibushita, Midori, Tsunetomi, Kyohei, Nagata, Mayu, Kajitani, Naofumi, Miura, Akihiko, Matsuo, Ryoichi, Nishiguchi, Tsuyoshi, Kato, Takahiro A., Setoyama, Daiki, Shirayama, Yukihiko, Watanabe, Ken, Shinozaki, Gen, Kaneko, Koichi
Publicado 2020

Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals

por Braun, Patricia R., Han, Shizhong, Hing, Benjamin, Nagahama, Yasunori, Gaul, Lindsey N., Heinzman, Jonathan T., Grossbach, Andrew J., Close, Liesl, Dlouhy, Brian J., Howard, Matthew A., Kawasaki, Hiroto, Potash, James B., Shinozaki, Gen
Publicado 2019

Stress increases blood beta‐hydroxybutyrate levels and prefrontal cortex NLRP3 activity jointly in a rodent model

por Nishiguchi, Tsuyoshi, Iwata, Masaaki, Kajitani, Naofumi, Miura, Akihiko, Matsuo, Ryoichi, Murakami, Shumei, Nakada, Yumeto, Pu, Shenghong, Shimizu, Yuki, Tsubakino, Tatsuya, Yamanashi, Takehiko, Shinozaki, Gen, Tsubota, Jun, Shirayama, Yukihiko, Watanabe, Ken, Kaneko, Koichi
Publicado 2021

Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders

por Zhou, Jiyun, Chen, Qiang, Braun, Patricia R., Perzel Mandell, Kira A., Jaffe, Andrew E., Tan, Hao Yang, Hyde, Thomas M., Kleinman, Joel E., Potash, James B., Shinozaki, Gen, Weinberger, Daniel R., Han, Shizhong
Publicado 2022

Cross-tissue correlations of genome-wide DNA methylation in Japanese live human brain and blood, saliva, and buccal epithelial tissues

por Nishitani, Shota, Isozaki, Makoto, Yao, Akiko, Higashino, Yoshifumi, Yamauchi, Takahiro, Kidoguchi, Masamune, Kawajiri, Satoshi, Tsunetoshi, Kenzo, Neish, Hiroyuki, Imoto, Hirochika, Arishima, Hidetaka, Kodera, Toshiaki, Fujisawa, Takashi X., Nomura, Sadahiro, Kikuta, Kenichiro, Shinozaki, Gen, Tomoda, Akemi
Publicado 2023

Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging

por Shinozaki, Gen, Braun, Patricia R., Hing, Benjamin W. Q., Ratanatharathorn, Andrew, Klisares, Mason J., Duncan, Gabrielle N., Jellison, Sydney S., Heinzman, Jonathan T., Nagahama, Yasunori, Close, Liesl, Sabbagh, Sayeh, Dlouhy, Brian J., Howard, Matthew A., Kawasaki, Hiroto, Cho, Hyunkeun R.
Publicado 2018

The genome‐wide DNA methylation profiles among neurosurgery patients with and without post‐operative delirium

por Yamanashi, Takehiko, Crutchley, Kaitlyn J., Wahba, Nadia E., Nagao, Takaaki, Marra, Pedro S., Akers, Cade C., Sullivan, Eleanor J., Iwata, Masaaki, Howard, Mathew A, Cho, Hyunkeun R., Kawasaki, Hiroto, Hughes, Christopher G., Pandharipande, Pratik P., Hefti, Marco M., Shinozaki, Gen
Publicado 2022

Topological data analysis (TDA) enhances bispectral EEG (BSEEG) algorithm for detection of delirium

por Yamanashi, Takehiko, Kajitani, Mari, Iwata, Masaaki, Crutchley, Kaitlyn J., Marra, Pedro, Malicoat, Johnny R., Williams, Jessica C., Leyden, Lydia R., Long, Hailey, Lo, Duachee, Schacher, Cassidy J., Hiraoka, Kazuaki, Tsunoda, Tomoyuki, Kobayashi, Ken, Ikai, Yoshiaki, Kaneko, Koichi, Umeda, Yuhei, Kadooka, Yoshimasa, Shinozaki, Gen
Publicado 2021

DNA methylation in the inflammatory genes after neurosurgery and diagnostic ability of post-operative delirium

por Yamanashi, Takehiko, Nagao, Takaaki, Wahba, Nadia E., Marra, Pedro S., Crutchley, Kaitlyn J., Meyer, Alissa A., Andreasen, Ally J., Hellman, Mandy M., Jellison, Sydney S., Hughes, Christopher G., Pandharipande, Pratik P., Howard, III, Matthew A., Kawasaki, Hiroto, Iwata, Masaaki, Hefti, Marco M., Shinozaki, Gen
Publicado 2021

Mortality among patients with sepsis associated with a bispectral electroencephalography (BSEEG) score

por Yamanashi, Takehiko, Marra, Pedro S., Crutchley, Kaitlyn J., Wahba, Nadia E., Malicoat, Johnny R., Sullivan, Eleanor J., Akers, Cade C., Nicholson, Catherine A., Herrmann, Felipe M., Karam, Matthew D., Noiseux, Nicolas O., Kaneko, Koichi, Shinozaki, Eri, Iwata, Masaaki, Cho, Hyunkeun Ryan, Lee, Sangil, Shinozaki, Gen
Publicado 2021

The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study

por Yamanashi, Takehiko, Anderson, Zoe-Ella EM, Modukuri, Manisha, Chang, Gloria, Tran, Tammy, Marra, Pedro S., Wahba, Nadia E., Crutchley, Kaitlyn J., Sullivan, Eleanor J., Jellison, Sydney S., Comp, Katie R., Akers, Cade C., Meyer, Alissa A., Lee, Sangil, Iwata, Masaaki, Cho, Hyunkeun R., Shinozaki, Eri, Shinozaki, Gen
Publicado 2022

Mortality prediction by bispectral electroencephalography among 502 patients: its role in dementia

por Saito, Taku, Malicoat, Johnny R, Leyden, Lydia R, Williams, Jessica C, Jellison, Sydney S, Long, Hailey, Hellman, Mandy M, Crutchley, Kaitlyn J, Anderson, Zoe-Ella E M, Lo, Duachee, Modukuri, Manisha V, Schacher, Cassidy J, Yoshino, Aihide, Toda, Hiroyuki, Shinozaki, Eri, Cho, Hyunkeun R, Lee, Sangil, Shinozaki, Gen
Publicado 2021