Coming to Terms with Complexity: Limits to a Reductionist View of Aging

por Shmookler Reis, Robert J.
Publicado 2012

Structural insights into pro-aggregation effects of C. elegans CRAM-1 and its human ortholog SERF2

por Balasubramaniam, Meenakshisundaram, Ayyadevara, Srinivas, Shmookler Reis, Robert J.
Publicado 2018

A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin

por Alagpulinsa, David A., Ayyadevara, Srinivas, Shmookler Reis, Robert Joseph
Publicado 2014

Positive Feedback between Transcriptional and Kinase Suppression in Nematodes with Extraordinary Longevity and Stress Resistance

por Tazearslan, Çagdaþ, Ayyadevara, Srinivas, Bharill, Puneet, Shmookler Reis, Robert J.
Publicado 2009

Extreme Depletion of PIP(3) Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants

por Bharill, Puneet, Ayyadevara, Srinivas, Alla, Ramani, Shmookler Reis, Robert J.
Publicado 2013

Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration

por Ayyadevara, Srinivas, Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Shmookler Reis, Robert J.
Publicado 2021

Machine-learning analysis of intrinsically disordered proteins identifies key factors that contribute to neurodegeneration-related aggregation

por Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Ayyadevara, Srinivas, Shmookler Reis, Robert J.
Publicado 2022

Protein homeostasis in the aged and diseased heart

por Mainali, Nirjal, Ayyadevara, Srinivas, Ganne, Akshatha, Shmookler Reis, Robert J., Mehta, Jawahar L.
Publicado 2023

Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease

por Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Griffin, W. Sue T., Shmookler Reis, Robert J., Ayyadevara, Srinivas
Publicado 2022

Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes

por Ayyadevara, Srinivas, Balasubramaniam, Meenakshisundaram, Gao, Yuan, Yu, Li-Rong, Alla, Ramani, Shmookler Reis, Robert
Publicado 2015

“Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation

por Shmookler Reis, Robert J., Atluri, Ramani, Balasubramaniam, Meenakshisundaram, Johnson, Jay, Ganne, Akshatha, Ayyadevara, Srinivas
Publicado 2021

Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases

por Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Mainali, Nirjal, Atluri, Paavan, Shmookler Reis, Robert J., Ayyadevara, Srinivas
Publicado 2022

Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans, and replicative lifespan in S. cerevisiae

por Ayyadevara, Srinivas, Tazearslan, Çagdas, Alla, Ramani, Jiang, James C., Jazwinski, S. Michal, Shmookler Reis, Robert J.
Publicado 2014

PIP(3)-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans

por Ayyadevara, Srinivas, Balasubramaniam, Meenakshisundaram, Johnson, Jay, Alla, Ramani, Mackintosh, Samuel G., Shmookler Reis, Robert J.
Publicado 2016

Label-free photothermal disruption of cytotoxic aggregates rescues pathology in a C. elegans model of Huntington’s disease

por Nedosekin, Dmitry A., Chen, TsungYen, Ayyadevara, Srinivas, Zharov, Vladimir P., Shmookler Reis, Robert J.
Publicado 2021

ALS-causing mutations in profilin-1 alter its conformational dynamics: A computational approach to explain propensity for aggregation

por Kiaei, Mahmoud, Balasubramaniam, Meenakshisundaram, Govind Kumar, Vivek, Shmookler Reis, Robert J., Moradi, Mahmoud, Varughese, Kottayil I.
Publicado 2018

In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration

por Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Ayyadevara, Haarika, Kiaei, Lily, Shmookler Reis, Robert J., Varughese, Kottayil I., Kiaei, Mahmoud
Publicado 2023

A universal transcriptomic signature of age reveals the temporal scaling of Caenorhabditis elegans aging trajectories

por Tarkhov, Andrei E., Alla, Ramani, Ayyadevara, Srinivas, Pyatnitskiy, Mikhail, Menshikov, Leonid I., Shmookler Reis, Robert J., Fedichev, Peter O.
Publicado 2019

Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs

por Balasubramaniam, Meenakshisundaram, Mainali, Nirjal, Bowroju, Suresh Kuarm, Atluri, Paavan, Penthala, Narsimha Reddy, Ayyadevera, Srinivas, Crooks, Peter A., Shmookler Reis, Robert J.
Publicado 2020

Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans

por Ayyadevara, Srinivas, Balasubramaniam, Meenakshisundaram, Suri, Pooja, Mackintosh, Samuel G., Tackett, Alan J., Sullivan, Dennis H., Shmookler Reis, Robert J., Dennis, Richard A.
Publicado 2016