Gamma motor neurons express distinct genetic markers at birth and require muscle spindle-derived GDNF for postnatal survival

por Shneider, Neil A, Brown, Meghan N, Smith, Courtney A, Pickel, James, Alvarez, Francisco J
Publicado 2009

Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis

por Korobeynikov, Vladislav A., Lyashchenko, Alexander K., Blanco-Redondo, Beatriz, Jafar-Nejad, Paymaan, Shneider, Neil A.
Publicado 2022

The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains

por Conlon, Erin G, Lu, Lei, Sharma, Aarti, Yamazaki, Takashi, Tang, Timothy, Shneider, Neil A, Manley, James L
Publicado 2016

ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs

por Tsai, Yueh-Lin, Coady, Tristan H., Lu, Lei, Zheng, Dinghai, Alland, Isabel, Tian, Bin, Shneider, Neil A., Manley, James L.
Publicado 2020

Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS

por Martínez-Silva, María de Lourdes, Imhoff-Manuel, Rebecca D, Sharma, Aarti, Heckman, CJ, Shneider, Neil A, Roselli, Francesco, Zytnicki, Daniel, Manuel, Marin
Publicado 2018

A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons

por Capauto, Davide, Colantoni, Alessio, Lu, Lei, Santini, Tiziana, Peruzzi, Giovanna, Biscarini, Silvia, Morlando, Mariangela, Shneider, Neil A., Caffarelli, Elisa, Laneve, Pietro, Bozzoni, Irene
Publicado 2018

Amyotrophic Lateral Sclerosis Modifiers in Drosophila Reveal the Phospholipase D Pathway as a Potential Therapeutic Target

por Kankel, Mark W., Sen, Anindya, Lu, Lei, Theodorou, Marina, Dimlich, Douglas N., McCampbell, Alexander, Henderson, Christopher E., Shneider, Neil A., Artavanis-Tsakonas, Spyros
Publicado 2020

ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function

por Sharma, Aarti, Lyashchenko, Alexander K., Lu, Lei, Nasrabady, Sara Ebrahimi, Elmaleh, Margot, Mendelsohn, Monica, Nemes, Adriana, Tapia, Juan Carlos, Mentis, George Z., Shneider, Neil A.
Publicado 2016

Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

por Conlon, Erin G, Fagegaltier, Delphine, Agius, Phaedra, Davis-Porada, Julia, Gregory, James, Hubbard, Isabel, Kang, Kristy, Kim, Duyang, Phatnani, Hemali, Shneider, Neil A, Manley, James L
Publicado 2018

Deletion of Ripk3 Prevents Motor Neuron Death In Vitro but not In Vivo

por Dermentzaki, Georgia, Politi, Kristin A., Lu, Lei, Mishra, Vartika, Pérez-Torres, Eduardo J., Sosunov, Alexander A., McKhann, Guy M., Lotti, Francesco, Shneider, Neil A., Przedborski, Serge
Publicado 2019

FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons

por Errichelli, Lorenzo, Dini Modigliani, Stefano, Laneve, Pietro, Colantoni, Alessio, Legnini, Ivano, Capauto, Davide, Rosa, Alessandro, De Santis, Riccardo, Scarfò, Rebecca, Peruzzi, Giovanna, Lu, Lei, Caffarelli, Elisa, Shneider, Neil A., Morlando, Mariangela, Bozzoni, Irene
Publicado 2017

Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging

por Tian, Feng, Yang, Wenlong, Mordes, Daniel A., Wang, Jin-Yuan, Salameh, Johnny S., Mok, Joanie, Chew, Jeannie, Sharma, Aarti, Leno-Duran, Ester, Suzuki-Uematsu, Satomi, Suzuki, Naoki, Han, Steve S., Lu, Fa-Ke, Ji, Minbiao, Zhang, Rosanna, Liu, Yue, Strominger, Jack, Shneider, Neil A., Petrucelli, Leonard, Xie, X. Sunney, Eggan, Kevin
Publicado 2016

A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS

por Gelfman, Sahar, Dugger, Sarah, de Araujo Martins Moreno, Cristiane, Ren, Zhong, Wolock, Charles J., Shneider, Neil A., Phatnani, Hemali, Cirulli, Elizabeth T., Lasseigne, Brittany N., Harris, Tim, Maniatis, Tom, Rouleau, Guy A., Brown, Robert H., Gitler, Aaron D., Myers, Richard M., Petrovski, Slavé, Allen, Andrew, Goldstein, David B., Harms, Matthew B.
Publicado 2019

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

por Murakami, Tetsuro, Qamar, Seema, Lin, Julie Qiaojin, Schierle, Gabriele S. Kaminski, Rees, Eric, Miyashita, Akinori, Costa, Ana R., Dodd, Roger B., Chan, Fiona T.S., Michel, Claire H., Kronenberg-Versteeg, Deborah, Li, Yi, Yang, Seung-Pil, Wakutani, Yosuke, Meadows, William, Ferry, Rodylyn Rose, Dong, Liang, Tartaglia, Gian Gaetano, Favrin, Giorgio, Lin, Wen-Lang, Dickson, Dennis W., Zhen, Mei, Ron, David, Schmitt-Ulms, Gerold, Fraser, Paul E., Shneider, Neil A., Holt, Christine, Vendruscolo, Michele, Kaminski, Clemens F., St George-Hyslop, Peter
Publicado 2015