A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability

por Guiley, Keelan Z., Shokat, Kevan M.
Publicado 2023

Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S)

por Zhang, Ziyang, Guiley, Keelan Z., Shokat, Kevan M.
Publicado 2022

Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors

por Lazarus, Michael B., Novotny, Chris J., Shokat, Kevan M.
Publicado 2014

Probing the KRas Switch II Groove by Fluorine NMR Spectroscopy

por Peacock, D. Matthew, Kelly, Mark J. S., Shokat, Kevan M.
Publicado 2022

Chemical Genetic Analysis of Protein Kinase Cascades

por Alaimo, Peter J., Shogren-Knaak, Michael A., Shokat, Kevan M.
Publicado 2002

Chemical genetic inhibition of DEAD-box proteins using covalent complementarity

por Barkovich, Krister J, Moore, Megan K, Hu, Qi, Shokat, Kevan M
Publicado 2018

Tissue-restricted inhibition of mTOR using chemical genetics

por Wassarman, Douglas R., Bankapalli, Kondalarao, Pallanck, Leo J., Shokat, Kevan M.
Publicado 2022

Dynamic Regulation of a Metabolic Multi-enzyme Complex by Protein Kinase CK2

por An, Songon, Kyoung, Minjoung, Allen, Jasmina J., Shokat, Kevan M., Benkovic, Stephen J.
Publicado 2010

Chemical Genetic Inhibition of Mps1 in Stable Human Cell Lines Reveals Novel Aspects of Mps1 Function in Mitosis

por Sliedrecht, Tale, Zhang, Chao, Shokat, Kevan M., Kops, Geert J. P. L.
Publicado 2010

RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild-type BRAF

por Poulikakos, Poulikos I., Zhang, Chao, Bollag, Gideon, Shokat, Kevan M., Rosen, Neal
Publicado 2010

Inhibition of ZAP-70 Kinase Activity via an Analog-sensitive Allele Blocks T Cell Receptor and CD28 Superagonist Signaling

por Levin, Susan E., Zhang, Chao, Kadlecek, Theresa A., Shokat, Kevan M., Weiss, Arthur
Publicado 2008

Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice

por Ehinger, Yann, Zhang, Ziyang, Phamluong, Khanhky, Soneja, Drishti, Shokat, Kevan M., Ron, Dorit
Publicado 2021

Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile

por Zhang, Ziyang, Morstein, Johannes, Ecker, Andrew K., Guiley, Keelan Z., Shokat, Kevan M.
Publicado 2022

Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma

por Lourido, Sebastian, Shuman, Joel, Zhang, Chao, Shokat, Kevan M., Hui, Raymond, Sibley, L. David
Publicado 2010

Brain-restricted mTOR inhibition with binary pharmacology

por Zhang, Ziyang, Fan, Qiwen, Luo, Xujun, Lou, Kevin, Weiss, William A., Shokat, Kevan M.
Publicado 2022

Protocol for performing and optimizing differential scanning fluorimetry experiments

por Wu, Taiasean, Hornsby, Michael, Zhu, Lawrence, Yu, Joshua C., Shokat, Kevan M., Gestwicki, Jason E.
Publicado 2023

Inhibition of Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full T cell receptor signaling

por Xim Tan, Ying, Manz, Boryana N., Freedman, Tanya, Zhang, Chao, Shokat, Kevan M., Weiss, Arthur
Publicado 2013

Site-specific incorporation of phosphotyrosine using an expanded genetic code

por Hoppmann, Christian, Wong, Allison, Yang, Bing, Li, Shuwei, Hunter, Tony, Shokat, Kevan M., Wang, Lei
Publicado 2017

A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation

por Kim, Joanne SM, Lilley, Brendan N, Zhang, Chao, Shokat, Kevan M, Sanes, Joshua R, Zhen, Mei
Publicado 2008

Inhibitor Hijacking of Akt Activation

por Okuzumi, Tatsuya, Fiedler, Dorothea, Zhang, Chao, Gray, Daniel C., Aizenstein, Brian, Hoffman, Randy, Shokat, Kevan M.
Publicado 2009