Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences

por Shon, D. Judy, Fernandez, Daniel, Riley, Nicholas M., Ferracane, Michael J., Bertozzi, Carolyn R.
Publicado 2022

Revealing the human mucinome

por Malaker, Stacy A., Riley, Nicholas M., Shon, D. Judy, Pedram, Kayvon, Krishnan, Venkatesh, Dorigo, Oliver, Bertozzi, Carolyn R.
Publicado 2022

Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals

por Pedram, Kayvon, Laqtom, Nouf N., Shon, D. Judy, Di Spiezio, Alessandro, Riley, Nicholas M., Saftig, Paul, Abu-Remaileh, Monther, Bertozzi, Carolyn R.
Publicado 2022

Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE

por Chongsaritsinsuk, Joann, Steigmeyer, Alexandra D., Mahoney, Keira E., Rosenfeld, Mia A., Lucas, Taryn M., Ince, Deniz, Kearns, Fiona L., Battison, Alexandria S., Hollenhorst, Marie A., Shon, D. Judy, Tiemeyer, Katherine H., Attah, Victor, Kwon, Catherine, Bertozzi, Carolyn R., Ferracane, Michael J., Amaro, Rommie E., Malaker, Stacy A.
Publicado 2023

The microenvironment dictates glycocalyx construction and immune surveillance

por Tharp, Kevin M., Park, Sangwoo, Timblin, Greg A., Richards, Alicia L., Berg, Jordan A., Twells, Nicholas M., Riley, Nicholas M., Peltan, Egan L., Shon, D. Judy, Stevenson, Erica, Tsui, Kimberly, Palomba, Francesco, Lefebvre, Austin E. Y. T., Soens, Ross W., Ayad, Nadia M.E., Hoeve-Scott, Johanna ten, Healy, Kevin, Digman, Michelle, Dillin, Andrew, Bertozzi, Carolyn R., Swaney, Danielle L., Mahal, Lara K., Cantor, Jason R., Paszek, Matthew J., Weaver, Valerie M.
Publicado 2023

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection

por Biering, Scott B., Sarnik, Sylvia A., Wang, Eleanor, Zengel, James R., Leist, Sarah R., Schäfer, Alexandra, Sathyan, Varun, Hawkins, Padraig, Okuda, Kenichi, Tau, Cyrus, Jangid, Aditya R., Duffy, Connor V., Wei, Jin, Gilmore, Rodney C., Alfajaro, Mia Madel, Strine, Madison S., Nguyenla, Xammy, Van Dis, Erik, Catamura, Carmelle, Yamashiro, Livia H., Belk, Julia A., Begeman, Adam, Stark, Jessica C., Shon, D. Judy, Fox, Douglas M., Ezzatpour, Shahrzad, Huang, Emily, Olegario, Nico, Rustagi, Arjun, Volmer, Allison S., Livraghi-Butrico, Alessandra, Wehri, Eddie, Behringer, Richard R., Cheon, Dong-Joo, Schaletzky, Julia, Aguilar, Hector C., Puschnik, Andreas S., Button, Brian, Pinsky, Benjamin A., Blish, Catherine A., Baric, Ralph S., O’Neal, Wanda K., Bertozzi, Carolyn R., Wilen, Craig B., Boucher, Richard C., Carette, Jan E., Stanley, Sarah A., Harris, Eva, Konermann, Silvana, Hsu, Patrick D.
Publicado 2022