Cwp84, a Clostridium difficile cysteine protease, exhibits conformational flexibility in the absence of its propeptide

por Bradshaw, William J., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi
Publicado 2015

Structure and function of a Clostridium difficile sortase enzyme

por Chambers, Christopher J., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi
Publicado 2015

The structure of the S-layer of Clostridium difficile

por Bradshaw, William J., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi
Publicado 2017

Expression, purification, crystallization and preliminary crystallographic analysis of a putative Clostridium difficile surface protein Cwp19

por Kirby, Jonathan M., Thiyagarajan, Nethaji, Roberts, April K., Shone, Clifford C., Acharya, K. Ravi
Publicado 2011

648. Urinary Tract-Associated Escherichia coli Bacteraemia Strains Are Genetically More Virulent than Those Originating From Non-urinary and Neutropaenic Infective Foci

por Dale, Adam, Pandey, Anish, Hesp, Richard, Belogiannis, Konstantinos, Laver, Jay, Shone, Clifford, Read, Robert
Publicado 2018

Cwp2 from Clostridium difficile exhibits an extended three domain fold and cell adhesion in vitro

por Bradshaw, William J., Kirby, Jonathan M., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi
Publicado 2017

The molecular structure of the glycoside hydrolase domain of Cwp19 from Clostridium difficile

por Bradshaw, William J., Kirby, Jonathan M., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi
Publicado 2017

Functional significance of active site residues in the enzymatic component of the Clostridium difficile binary toxin

por Davies, Abigail H., McGlashan, Joanna, Posner, Mareike G., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi
Publicado 2016

Genomes of Escherichia coli bacteraemia isolates originating from urinary tract foci contain more virulence-associated genes than those from non-urinary foci and neutropaenic hosts

por Dale, Adam P., Pandey, Anish K., Hesp, Richard J., Belogiannis, Konstantinos, Laver, Jay R., Shone, Clifford C., Read, Robert C.
Publicado 2018

Recombinant antigens based on toxins A and B of Clostridium difficile that evoke a potent toxin-neutralising immune response()

por Maynard-Smith, Michael, Ahern, Helen, McGlashan, Joanna, Nugent, Philip, Ling, Roger, Denton, Harriet, Coxon, Ruth, Landon, John, Roberts, April, Shone, Clifford
Publicado 2014

The structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer-associated protein from Clostridium difficile

por Bradshaw, William J., Kirby, Jonathan M., Thiyagarajan, Nethaji, Chambers, Christopher J., Davies, Abigail H., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi
Publicado 2014

High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection again...

por Monaghan, Tanya M, Negm, Ola H, MacKenzie, Brendon, Hamed, Mohamed R, Shone, Clifford C, Humphreys, David P, Acharya, K Ravi, Wilcox, Mark H
Publicado 2017

A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins

por Azarnia Tehran, Domenico, Zanetti, Giulia, Leka, Oneda, Lista, Florigio, Fillo, Silvia, Binz, Thomas, Shone, Clifford C., Rossetto, Ornella, Montecucco, Cesare, Paradisi, Cristina, Mattarei, Andrea, Pirazzini, Marco
Publicado 2015

A Novel, Orally Delivered Antibody Therapy and Its Potential to Prevent Clostridioides difficile Infection in Pre-clinical Models

por Roberts, April K., Harris, Hannah C., Smith, Michael, Giles, Joanna, Polak, Oktawia, Buckley, Anthony M., Clark, Emma, Ewin, Duncan, Moura, Ines B., Spitall, William, Shone, Clifford C., Wilcox, Mark, Chilton, Caroline, Donev, Rossen
Publicado 2020

Confocal Endomicroscopy of Neuromuscular Junctions Stained with Physiologically Inert Protein Fragments of Tetanus Toxin

por Roesl, Cornelia, Evans, Elizabeth R., Dissanayake, Kosala N., Boczonadi, Veronika, Jones, Ross A., Jordan, Graeme R., Ledahawsky, Leire, Allen, Guy C. C., Scott, Molly, Thomson, Alanna, Wishart, Thomas M., Hughes, David I., Mead, Richard J., Shone, Clifford C., Slater, Clarke R., Gillingwater, Thomas H., Skehel, Paul A., Ribchester, Richard R.
Publicado 2021