Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration

por Hallam, Thomas M., Marchbank, Kevin J., Harris, Claire L., Osmond, Clive, Shuttleworth, Victoria G., Griffiths, Helen, Cree, Angela J., Kavanagh, David, Lotery, Andrew J.
Publicado 2020

Functional Characterization of Rare Genetic Variants in the N-Terminus of Complement Factor H in aHUS, C3G, and AMD

por Wong, Edwin K. S., Hallam, Thomas M., Brocklebank, Vicky, Walsh, Patrick R., Smith-Jackson, Kate, Shuttleworth, Victoria G., Cox, Thomas E., Anderson, Holly E., Barlow, Paul Nigel, Marchbank, Kevin James, Harris, Claire L., Kavanagh, David
Publicado 2021

MiR-126-3p Is Dynamically Regulated in Endothelial-to-Mesenchymal Transition during Fibrosis

por Jordan, Nina P., Tingle, Samuel J., Shuttleworth, Victoria G., Cooke, Katie, Redgrave, Rachael E., Singh, Esha, Glover, Emily K., Ahmad Tajuddin, Hafiza B., Kirby, John A., Arthur, Helen M., Ward, Chris, Sheerin, Neil S., Ali, Simi
Publicado 2021

A novel method for real-time analysis of the complement C3b:FH:FI complex reveals dominant negative CFI variants in age-related macular degeneration

por Hallam, Thomas M., Cox, Thomas E., Smith-Jackson, Kate, Brocklebank, Vicky, Baral, April J., Tzoumas, Nikolaos, Steel, David H., Wong, Edwin K. S., Shuttleworth, Victoria G., Lotery, Andrew J., Harris, Claire L., Marchbank, Kevin J., Kavanagh, David
Publicado 2022