Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B∼ubiquitin complex

por Patel, Amrita, Sibbet, Gary J., Huang, Danny T.
Publicado 2019

Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3

por Dou, Hao, Buetow, Lori, Sibbet, Gary J., Cameron, Kenneth, Huang, Danny T.
Publicado 2013

Structure of UBE2K–Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension

por Nakasone, Mark A., Majorek, Karolina A., Gabrielsen, Mads, Sibbet, Gary J., Smith, Brian O., Huang, Danny T.
Publicado 2022

Deep Evolutionary Conservation of an Intramolecular Protein Kinase Activation Mechanism

por Han, Jingfen, Miranda-Saavedra, Diego, Luebbering, Nathan, Singh, Aman, Sibbet, Gary, Ferguson, Michael A. J., Cleghon, Vaughn
Publicado 2012

DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination

por Ahmed, Syed Feroj, Buetow, Lori, Gabrielsen, Mads, Lilla, Sergio, Chatrin, Chatrin, Sibbet, Gary J., Zanivan, Sara, Huang, Danny T.
Publicado 2020

Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation

por Buetow, Lori, Tria, Giancarlo, Ahmed, Syed Feroj, Hock, Andreas, Dou, Hao, Sibbet, Gary J., Svergun, Dmitri I., Huang, Danny T.
Publicado 2016

A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants

por Gabrielsen, Mads, Buetow, Lori, Nakasone, Mark A., Ahmed, Syed Feroj, Sibbet, Gary J., Smith, Brian O., Zhang, Wei, Sidhu, Sachdev S., Huang, Danny T.
Publicado 2017

Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases

por Chatrin, Chatrin, Gabrielsen, Mads, Buetow, Lori, Nakasone, Mark A., Ahmed, Syed F., Sumpton, David, Sibbet, Gary J., Smith, Brian O., Huang, Danny T.
Publicado 2020

E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK–CBL–CIN85 axis

por Ahmed, Syed Feroj, Buetow, Lori, Gabrielsen, Mads, Lilla, Sergio, Sibbet, Gary J., Sumpton, David, Zanivan, Sara, Hedley, Ann, Clark, William, Huang, Danny T.
Publicado 2021

Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain

por Magnussen, Helge M., Ahmed, Syed F., Sibbet, Gary. J., Hristova, Ventzislava A., Nomura, Koji, Hock, Andreas K., Archibald, Lewis J., Jamieson, Andrew G., Fushman, David, Vousden, Karen H., Weissman, Allan M., Huang, Danny T.
Publicado 2020

Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells

por Spender, Lindsay C., Ferguson, G. John, Liu, Sijia, Cui, Chao, Girotti, Maria Romina, Sibbet, Gary, Higgs, Ellen B., Shuttleworth, Morven K., Hamilton, Tom, Lorigan, Paul, Weller, Michael, Vincent, David F., Sansom, Owen J., Frame, Margaret, Dijke, Peter ten, Marais, Richard, Inman, Gareth J.
Publicado 2016