The structural and functional workings of KEOPS

por Beenstock, Jonah, Sicheri, Frank
Publicado 2021

Putting the brakes on the unfolded protein response

por Sicheri, Frank, Silverman, Robert H.
Publicado 2011

Aurora A kinase activation: Different means to different ends

por Tavernier, Nicolas, Sicheri, Frank, Pintard, Lionel
Publicado 2021

Expression and purification of functional human glycogen synthase-1:glycogenin-1 complex in insect cells

por Hunter, Roger W., Zeqiraj, Elton, Morrice, Nicholas, Sicheri, Frank, Sakamoto, Kei
Publicado 2015

The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency

por Manczyk, Noah, Veggiani, Gianluca, Teyra, Joan, Strilchuk, Amy W., Sidhu, Sachdev S., Sicheri, Frank
Publicado 2019

Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t(6)A biosynthesis

por Wan, Leo C.K., Pillon, Monica C., Thevakumaran, Neroshan, Sun, Yulong, Chakrabartty, Avi, Guarné, Alba, Kurinov, Igor, Durocher, Daniel, Sicheri, Frank
Publicado 2016

Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase

por Shehata, Saifeldin N., Hunter, Roger W., Ohta, Eriko, Peggie, Mark W., Lou, Hua Jane, Sicheri, Frank, Zeqiraj, Elton, Turk, Benjamin E., Sakamoto, Kei
Publicado 2012

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay

por Koszela, Joanna, Pham, Nhan T., Evans, David, Mann, Stefan, Perez-Pi, Irene, Shave, Steven, Ceccarelli, Derek F. J., Sicheri, Frank, Tyers, Mike, Auer, Manfred
Publicado 2018

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization

por Lavoie, Hugo, Thevakumaran, Neroshan, Gavory, Gwenaëlle, Li, John, Padeganeh, Abbas, Guiral, Sébastien, Duchaine, Jean, Mao, Daniel Y. L., Bouvier, Michel, Sicheri, Frank, Therrien, Marc
Publicado 2013

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

por Hunter, Roger W., Hughey, Curtis C., Lantier, Louise, Sundelin, Elias I., Peggie, Mark, Zeqiraj, Elton, Sicheri, Frank, Jessen, Niels, Wasserman, David H., Sakamoto, Kei
Publicado 2018

MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway

por Couzens, Amber L., Xiong, Shawn, Knight, James D. R., Mao, Daniel Y., Guettler, Sebastian, Picaud, Sarah, Kurinov, Igor, Filippakopoulos, Panagis, Sicheri, Frank, Gingras, Anne-Claude
Publicado 2017

A screen for MeCP2-TBL1 interaction inhibitors using a luminescence-based assay

por Alexander-Howden, Beatrice, Zhang, Li, van der Sloot, Almer M., Tollis, Sylvain, St-Cyr, Daniel J., Sicheri, Frank, Bird, Adrian P., Tyers, Mike, Lyst, Matthew J.
Publicado 2023

An allosteric conduit facilitates dynamic multisite substrate recognition by the SCF(Cdc4) ubiquitin ligase

por Csizmok, Veronika, Orlicky, Stephen, Cheng, Jing, Song, Jianhui, Bah, Alaji, Delgoshaie, Neda, Lin, Hong, Mittag, Tanja, Sicheri, Frank, Chan, Hue Sun, Tyers, Mike, Forman-Kay, Julie D.
Publicado 2017

Dissecting BAR Domain Function in the Yeast Amphiphysins Rvs161 and Rvs167 during Endocytosis

por Youn, Ji-Young, Friesen, Helena, Kishimoto, Takuma, Henne, William M., Kurat, Christoph F., Ye, Wei, Ceccarelli, Derek F., Sicheri, Frank, Kohlwein, Sepp D., McMahon, Harvey T., Andrews, Brenda J.
Publicado 2010

E2 enzyme inhibition by stabilization of a low affinity interface with ubiquitin

por Huang, Hao, Ceccarelli, Derek F, Orlicky, Stephen, St-Cyr, Daniel J., Ziemba, Amy, Garg, Pankaj, Plamondon, Serge, Auer, Manfred, Sidhu, Sachdev, Marinier, Anne, Kleiger, Gary, Tyers, Mike, Sicheri, Frank
Publicado 2013

Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment

por Xiong, Shawn, Lorenzen, Kristina, Couzens, Amber L., Templeton, Catherine M., Rajendran, Dushyandi, Mao, Daniel Y.L., Juang, Yu-Chi, Chiovitti, David, Kurinov, Igor, Guettler, Sebastian, Gingras, Anne-Claude, Sicheri, Frank
Publicado 2018

OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug

por Banerjee, Shuvojit, Gusho, Elona, Gaughan, Christina, Dong, Beihua, Gu, Xiaorong, Holvey-Bates, Elise, Talukdar, Manisha, Li, Yize, Weiss, Susan R., Sicheri, Frank, Saunthararajah, Yogen, Stark, George R., Silverman, Robert H.
Publicado 2019

53BP1 is a reader of the DNA damage-induced H2A Lys15 ubiquitin mark

por Fradet-Turcotte, Amélie, Canny, Marella D., Escribano-Díaz, Cristina, Orthwein, Alexandre, Leung, Charles C.Y., Huang, Hao, Landry, Marie-Claude, Kitevski-LeBlanc, Julianne, Noordermeer, Sylvie M., Sicheri, Frank, Durocher, Daniel
Publicado 2013

Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7

por Wan, Leo C.K., Maisonneuve, Pierre, Szilard, Rachel K., Lambert, Jean-Philippe, Ng, Timothy F., Manczyk, Noah, Huang, Hao, Laister, Rob, Caudy, Amy A., Gingras, Anne-Claude, Durocher, Daniel, Sicheri, Frank
Publicado 2017

Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system

por Wan, Leo C. K., Mao, Daniel Y. L., Neculai, Dante, Strecker, Jonathan, Chiovitti, David, Kurinov, Igor, Poda, Gennadiy, Thevakumaran, Neroshan, Yuan, Fang, Szilard, Rachel K., Lissina, Elena, Nislow, Corey, Caudy, Amy A., Durocher, Daniel, Sicheri, Frank
Publicado 2013