Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects

por Sidharta, Patricia N, Melchior, Meggane, Kankam, Martin K, Dingemanse, Jasper
Publicado 2019

Relative bioavailability of a pediatric dispersible tablet and adult film‐coated tablet of macitentan in healthy volunteers

por Sidharta, Patricia N., Štěpánová, Radka, Globig, Susanne, Ulč, Ivan, Csonka, Dénes
Publicado 2020

Macitentan: entry-into-humans study with a new endothelin receptor antagonist

por Sidharta, Patricia N., van Giersbergen, Paul L. M., Halabi, Atef, Dingemanse, Jasper
Publicado 2011

Assessment of Target Engagement in a First‐in‐Human Trial with Sinbaglustat, an Iminosugar to Treat Lysosomal Storage Disorders

por Gehin, Martine, Melchior, Meggane, Welford, Richard W.D., Sidharta, Patricia N., Dingemanse, Jasper
Publicado 2020

Single-dose pharmacokinetics, safety, and tolerability of the dual endothelin receptor antagonist aprocitentan in subjects with moderate hepatic impairment

por Fontes, Magda S. C., Dingemanse, Jasper, Halabi, Atef, Tomaszewska-Kiecana, Monika, Sidharta, Patricia N.
Publicado 2022

The effect of the glucosylceramide synthase inhibitor lucerastat on cardiac repolarization: results from a thorough QT study in healthy subjects

por Mueller, Markus S., Sidharta, Patricia N., Voors-Pette, Christine, Darpo, Borje, Xue, Hongqi, Dingemanse, Jasper
Publicado 2020

Bioequivalence of macitentan and tadalafil given as fixed‐dose combination or single‐component tablets in healthy subjects

por Grill, Simon, Bruderer, Shirin, Sidharta, Patricia N., Antonova, Mariya, Globig, Susanne, Carlson, James, Schultz, Armin, Csonka, Dénes
Publicado 2020

Effect of Cyclosporine and Rifampin on the Pharmacokinetics of Macitentan, a Tissue-Targeting Dual Endothelin Receptor Antagonist

por Bruderer, Shirin, Äänismaa, Päivi, Homery, Marie-Claude, Häusler, Stephanie, Landskroner, Kyle, Sidharta, Patricia N., Treiber, Alexander, Dingemanse, Jasper
Publicado 2011

Absorption, Metabolism, and Excretion of ACT-1004-1239, a First-In-Class CXCR7 Antagonist: In Vitro, Preclinical, and Clinical Data

por Huynh, Christine, Seeland, Swen, Segrestaa, Jerome, Gnerre, Carmela, Hogeback, Jens, Meyer zu Schwabedissen, Henriette E., Dingemanse, Jasper, Sidharta, Patricia N.
Publicado 2022

Effects of the Dual Endothelin Receptor Antagonist Aprocitentan on Body Weight and Fluid Homeostasis in Healthy Subjects on a High Sodium Diet

por Gueneau de Mussy, Pierre, Sidharta, Patricia N., Wuerzner, Gregoire, Maillard, Marc P., Guérard, Nicolas, Iglarz, Marc, Flamion, Bruno, Dingemanse, Jasper, Burnier, Michel
Publicado 2020